2. Gene
  3. PKN3 - protein kinase N3 Gene

PKN3 - protein kinase N3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UTDP4-1

Gene ID: 29941 | Gene type: protein coding

About PKN3

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,702,503-128,720,916 (from NCBI)

This gene has 3 transcripts (splice variants), 291 orthologues and 9 paralogues. Ubiquitous expression in fat (RPKM 3.9), lung (RPKM 3.1) and 25 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Involved in epithelial cell migration. Predicted to be located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

PKN3 Products(2)

mRNA Protein Name
NM_001317926.2 NP_001304855.1 serine/threonine-protein kinase N3 isoform 2
NM_013355.5 NP_037487.2 serine/threonine-protein kinase N3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11432776 GOA
Biological Process GO Annotation Evidence Reference Source
involved in epithelial cell migration IDA
IDA: Inferred from direct assay
21754995 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKN3 Protein Structure

HR1

HR1: Hr1 repeat (20 - 79)

HR1

HR1: Hr1 repeat (107 - 171)

HR1

HR1: Hr1 repeat (180 - 247)

Pkinase

Pkinase: Protein kinase domain (560 - 817)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (841 - 884)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 889 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase N3

protein kinase PKN-beta

PKN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PKN3 Q6P5Z2 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
PKN3 Q6P5Z2 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
PKN3 Q6P5Z2 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
PKN3 Q6P5Z2 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
PKN3 Q6P5Z2 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
PKN3 Q6P5Z2 ARHGAP26 Homo sapiens Q9UNA1
Pull Down
32707033
Intra
PKN3 Q6P5Z2 ARHGAP26 Homo sapiens Q9UNA1
Anti Tag CoIP
11432776
Intra
PKN3 Q6P5Z2 ARHGAP26 Homo sapiens Q9UNA1
Y2H
11432776
Intra
PKN3 Q6P5Z2 ARHGAP10 Homo sapiens A1A4S6
Pull Down
32707033
Intra
PKN3 Q6P5Z2 ARHGAP10 Homo sapiens A1A4S6
Y2H
11432776
Intra
PKN3 Q6P5Z2 ARHGAP10 Homo sapiens A1A4S6
Anti Tag CoIP
11432776
Intra
PKN3 Q6P5Z2 ARHGAP10 Homo sapiens A1A4S6
Pull Down
11432776
Intra
PKN3 Q6P5Z2 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra
PKN3 Q6P5Z2 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra
PKN3 Q6P5Z2 VPS52 Homo sapiens Q8N1B4
Validated Y2H
32296183
Intra
PKN3 Q6P5Z2 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra
PKN3 Q6P5Z2 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra
PKN3 Q6P5Z2 PNMA1 Homo sapiens Q8ND90
Validated Y2H
32296183
Intra
PKN3 Q6P5Z2 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
PKN3 Q6P5Z2 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
PKN3 Q6P5Z2 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
PKN3 Q6P5Z2 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nonarteritic Anterior Ischemic Optic Neuropathy

Anterior Ischemic Optic Neuropathy

Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To

NAION

Non-Arteritic Anterior Ischemic Optic Neuropathy

Ischemic Optic Neuropathy

Aion

Optic Neuropathy, Ischemic

Naion, Susceptibility To

Optic Neuropathy, Anterior Ischemic

Optic Neuropathy, Anterior Ischemic, Susceptibility To

Non-Arteritic Anterior Ischaemic Optic Neuropathy

Nonarteritic Anterior Ischaemic Optic Neuropathy

Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility To

Ion - [Ischemic Optic Neuropathy]

Neuropathic Ischaemia Of N.Opticus

Ischaemic Neuropathy Of Optic Nerve
Gastrointestinal Neuroendocrine Tumor

Gastrointestinal Neuroendocrine Tumour

Malignant Gastrointestinal Neuroendocrine Tumor

Malignant Gastrointestinal Neuroendocrine Tumour

Digestive System Neuroendocrine Neoplasm

Digestive System Neuroendocrine Tumor
Pachyonychia Congenita 1

Pachyonychia Congenita

Jadassohn-Lewandowsky Syndrome

Pachyonychia Congenita Syndrome

PC1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type

Congenital Pachyonychia

Pachyonychia Congenita, Type 1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly

Jadassohn-Lewandowsky Syndrome, Formerly

Jackson-Lawler Type Pachyonychia Congenita

Pachyonychia Congenita Type 1

Jackson-Lawler Syndrome

Jadassohn-Lewandowski Syndrome

Pc

Pachyonychia Congenita Jackson-Lawler Type

Pachyonychia Congenita Jadassohn-Lewandowsky Type

Pachyonychia Congenita Jackson Lawler Type

Pc-1

Pachyonychia Congenita, Jadassohn Lewandowsky Type

Pachyonychia Congenita, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-153482 ATU027 / Phase 2
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148065 FMF-06-098-1 / Unkown
HY-153482A ATU027 sodium Inhibitor / Unkown
HY-RS10608 PKN3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PKN3 RGD RGD:1305921
Felis catus PKN3 VGNC VGNC:64195
Bos taurus PKN3 VGNC VGNC:32947
Canis familiaris PKN3 VGNC VGNC:44613
Macaca mulatta PKN3 VGNC VGNC:75824
Mus musculus PKN3 MGD MGI:2388285