CAMTA2 - calmodulin binding transcription activator 2 Gene

Homo sapiens

Gene ID: 23125 | Gene type: protein coding

About CAMTA2

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,967,997-4,987,675 (from NCBI)

This gene has 16 transcripts (splice variants), 190 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 16.2), testis (RPKM 10.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]

CAMTA2 Products(4)

mRNA	Protein	Name
NM_001171166.2	NP_001164637.1	calmodulin-binding transcription activator 2 isoform 2
NM_001171167.2	NP_001164638.1	calmodulin-binding transcription activator 2 isoform 4
NM_001171168.2	NP_001164639.1	calmodulin-binding transcription activator 2 isoform 3
NM_015099.4	NP_055914.2	calmodulin-binding transcription activator 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	16678093	GOA
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	16678093	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16678093	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	16678093	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cardiac muscle hypertrophy in response to stress	IDA IDA: Inferred from direct assay	16678093	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16678093	GOA
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16678093	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	16678093	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16678093	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMTA2 Protein Structure

CG-1

TIG

0
200
400
600
800
1000
1202 a.a.

Protein Preferred Names

Protein Names

calmodulin-binding transcription activator 2

CAMTA2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	CAMTA2	O94983	Nkx2-5	Mus musculus	P42582	Pull Down	16678093

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 22

RP22	Retinitis Pigmentosa-22

Hereditary Lymphedema I

Lymphedema	Hereditary Lymphedema Type I
Congenital Primary Lymphedema	Lmph1
Milroy Disease	Nonne-Milroy Lymphedema
Pcl	Lymphedema Hereditary Type 1

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01875	CAMTA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CAMTA2	VGNC	VGNC:60343
Mus musculus	CAMTA2	MGD	MGI:2135957
Canis familiaris	CAMTA2	VGNC	VGNC:38693
Rattus norvegicus	CAMTA2	RGD	RGD:1311296
Macaca mulatta	CAMTA2	VGNC	VGNC:70578
Bos taurus	CAMTA2	VGNC	VGNC:26733

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