COLGALT2 - collagen beta(1-O)galactosyltransferase 2 Gene

Homo sapiens

Also known as C1orf17; GLT25D2; ColGalT 2

Gene ID: 23127 | Gene type: protein coding

About COLGALT2

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:183,929,662-184,037,728 (from NCBI)

This gene has 5 transcripts (splice variants), 243 orthologues and 5 paralogues. Biased expression in brain (RPKM 11.8), adrenal (RPKM 2.5) and 7 other tissues.

Summary

Predicted to enable procollagen galactosyltransferase activity. Predicted to be involved in collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Apr 2022]

COLGALT2 Products(3)

mRNA	Protein	Name
NM_001303420.2	NP_001290349.1	procollagen galactosyltransferase 2 isoform 2 precursor
NM_001303421.2	NP_001290350.1	procollagen galactosyltransferase 2 isoform 3
NM_015101.4	NP_055916.1	procollagen galactosyltransferase 2 isoform 1precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COLGALT2 Protein Structure

Glyco_tranf_2_4

Glyco_transf_25

0
100
200
300
400
500
626 a.a.

Protein Preferred Names

Protein Names

procollagen galactosyltransferase 2

glycosyltransferase 25 domain containing 2

COLGALT2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	COLGALT2	Q8IYK4	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	COLGALT2	Q8IYK4	HPCAL1	Homo sapiens	P37235	Y2H Prey Pooling	32296183
Intra	COLGALT2	Q8IYK4	HPCAL1	Homo sapiens	P37235	MAPPIT	32296183
Intra	COLGALT2	Q8IYK4	HPCAL1	Homo sapiens	P37235	Y2H Array	32296183
Intra	COLGALT2	Q8IYK4	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	COLGALT2	Q8IYK4	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	COLGALT2	Q8IYK4	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant COLGALT2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76954	GLT25D2 Protein, Human (sf9, His)	Q8IYK4 (M1-S622)	≥95%

Related Diseases

Diseases

Alias

Osteogenesis Imperfecta, Type Ix

Osteogenesis Imperfecta Type 9	Osteogenesis Imperfecta Type Ix
OI9	Oi Type Ix
Osteogenesis Imperfecta Sillence Type Ii/Iii Without Abnormality Of Type I Collagen	Oi, Type Ix
Oi 9	Osteogenesis Imperfecta 9
Oi-Ix

Bruck Syndrome

Osteogenesis Imperfecta With Congenital Joint Contractures

Osteogenesis Imperfecta-Congenital Joint Contractures Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03007	COLGALT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	COLGALT2	VGNC	VGNC:99871
Felis catus	COLGALT2	VGNC	VGNC:107862
Canis familiaris	COLGALT2	VGNC	VGNC:53337
Mus musculus	COLGALT2	MGD	MGI:2138232
Rattus norvegicus	COLGALT2	RGD	RGD:1304702
Others	COLGALT2	NCBI

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