DCUN1D4 - defective in cullin neddylation 1 domain containing 4 Gene

Homo sapiens

Also known as DCNL4

Gene ID: 23142 | Gene type: protein coding

About DCUN1D4

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:51,833,884-51,916,837 (from NCBI)

This gene has 22 transcripts (splice variants), 215 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 10.1), adrenal (RPKM 8.7) and 25 other tissues.

Summary

Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

DCUN1D4 Products(4)

mRNA	Protein	Name
NM_001040402.3	NP_001035492.1	DCN1-like protein 4 isoform 1
NM_001287755.1	NP_001274684.1	DCN1-like protein 4 isoform 3
NM_001287757.2	NP_001274686.1	DCN1-like protein 4 isoform 4
NM_015115.4	NP_055930.2	DCN1-like protein 4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cullin family protein binding	IMP IMP: Inferred from mutant phenotype	23201271	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21911577	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of protein neddylation	IMP IMP: Inferred from mutant phenotype	23201271	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IMP IMP: Inferred from mutant phenotype	26906416	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCUN1D4 Protein Structure

Cullin_binding

0
100
200
292 a.a.

Protein Preferred Names

Protein Names

DCN1-like protein 4

DCN1, defective in cullin neddylation 1, domain containing 4

DCUN1D4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	DCUN1D4	Q92564	P29991-PRO_0000037946	Dengue virus type 2	P29991-PRO_0000037946	Y2H	21911577
Cross	DCUN1D4	Q92564	P29991-PRO_0000037946	Dengue virus type 2	P29991-PRO_0000037946	Split-Luc	21911577

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03599	DCUN1D4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DCUN1D4	VGNC	VGNC:39824
Mus musculus	DCUN1D4	MGD	MGI:2140972
Felis catus	DCUN1D4	VGNC	VGNC:61383
Rattus norvegicus	DCUN1D4	RGD	RGD:1310422
Bos taurus	DCUN1D4	VGNC	VGNC:53698
Macaca mulatta	DCUN1D4	VGNC	VGNC:71809

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