LRCH1 - leucine rich repeats and calponin homology domain containing 1 Gene

Homo sapiens

Also known as NP81; CHDC1

Gene ID: 23143 | Gene type: protein coding

About LRCH1

Cytogenetic location: 13q14.13-q14.2 Genomic coordinates (GRCh38): 13:46,553,170-46,753,041 (from NCBI)

This gene has 6 transcripts (splice variants), 198 orthologues and 31 paralogues. Ubiquitous expression in endometrium (RPKM 5.5), placenta (RPKM 5.5) and 25 other tissues.

Summary

This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]

LRCH1 Products(3)

mRNA	Protein	Name
NM_001164211.2	NP_001157683.2	leucine-rich repeat and calponin homology domain-containing protein 1 isoform 1
NM_001164213.2	NP_001157685.2	leucine-rich repeat and calponin homology domain-containing protein 1 isoform 3
NM_015116.3	NP_055931.2	leucine-rich repeat and calponin homology domain-containing protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24255178	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to chemokine	IMP IMP: Inferred from mutant phenotype	28028151	GOA
involved in negative regulation of GTPase activity	IDA IDA: Inferred from direct assay	28028151	GOA
involved in negative regulation of T cell migration	IMP IMP: Inferred from mutant phenotype	28028151	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	28028151	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRCH1 Protein Structure

LRR_8

0
200
400
600
728 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat and calponin homology domain-containing protein 1

leucine-rich repeats and calponin homology (CH) domain containing 1

LRCH1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LRCH1	Q9Y2L9	DOCK8	Homo sapiens	Q8NF50-2	Y2H Array	25416956
Intra	LRCH1	Q9Y2L9	DOCK7	Homo sapiens	Q96N67	Anti Tag CoIP	33961781
Intra	LRCH1	Q9Y2L9	DOCK7	Homo sapiens	Q96N67	Anti Tag CoIP	29467281
Intra	LRCH1	Q9Y2L9	DOCK8	Homo sapiens	Q8NF50	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Osteoarthritis

Osteoarthrosis	Degenerative Joint Disease
Hypertrophic Arthritis	Arthropathy
Degenerative Polyarthritis	Degenerative Arthritis
Osteoarthrosis And Allied Disorder	Arthritis, Degenerative
Oa	Osteoarthritis Deformans
Osteoarthrosis Deformans	Kashin-Beck Disease

Cardiomyopathy, Familial Hypertrophic, 2

Hypertrophic Cardiomyopathy 2	CMH2
Cardiomyopathy, Hypertrophic, 2	Cardiomyopathy Familial Hypertrophic 2
Cardiomyopathy, Familial Hypertrophic 2	Cardiomyopathy, Hypertrophic, Familial, Type 2

Osteogenesis Imperfecta, Type Xv

Osteogenesis Imperfecta Type 15	OI15
Osteogenesis Imperfecta Type Xv	Oi, Type Xv
Osteogenesis Imperfecta 15	Oi Type Xv
Oi-Xv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07778	LRCH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LRCH1	VGNC	VGNC:74317
Bos taurus	LRCH1	VGNC	VGNC:53822
Canis familiaris	LRCH1	VGNC	VGNC:49754
Rattus norvegicus	LRCH1	RGD	RGD:1595678
Mus musculus	LRCH1	MGD	MGI:2443390

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