NACAD - NAC alpha domain containing Gene

Homo sapiens

Gene ID: 23148 | Gene type: protein coding

About NACAD

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:45,080,437-45,088,969 (from NCBI)

This gene has 2 transcripts (splice variants), 186 orthologues and 2 paralogues. Biased expression in brain (RPKM 25.2), ovary (RPKM 5.5) and 11 other tissues.

Summary

Predicted to enable unfolded protein binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in nucleus. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NACAD Products(1)

mRNA	Protein	Name
NM_001146334.2	NP_001139806.1	NAC-alpha domain-containing protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NACAD Protein Structure

NAC

0
300
600
900
1200
1562 a.a.

Protein Preferred Names

Protein Names

NAC-alpha domain-containing protein 1

NACAD Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NACAD	O15069	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	NACAD	O15069	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	NACAD	O15069	HTT	Homo sapiens	P42858	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Small Intestine Lymphoma

Small Intestinal Lymphoma

Liver Sarcoma

Hepatic Sarcoma

Sarcoma Of Liver

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09001	NACAD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NACAD	VGNC	VGNC:53662
Macaca mulatta	NACAD	VGNC	VGNC:81725
Rattus norvegicus	NACAD	RGD	RGD:1559824
Mus musculus	NACAD	MGD	MGI:3603030

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