RTF1 - RTF1 homolog, Paf1/RNA polymerase II complex component Gene

Homo sapiens

Also known as GTL7; KIAA0252

Gene ID: 23168 | Gene type: protein coding

About RTF1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,417,095-41,483,563 (from NCBI)

This gene has 7 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in thyroid (RPKM 16.0), testis (RPKM 15.7) and 25 other tissues.

Summary

This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in Other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010]

RTF1 Products(1)

mRNA	Protein	Name
NM_015138.5	NP_055953.3	RNA polymerase-associated protein RTF1 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15923622	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	18184592	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in stem cell population maintenance	IDA IDA: Inferred from direct assay	19345177	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	20178742	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cdc73/Paf1 complex	IDA IDA: Inferred from direct assay	20178742	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTF1 Protein Structure

Plus-3

0
200
400
600
710 a.a.

Protein Preferred Names

Protein Names

RNA polymerase-associated protein RTF1 homolog

Rtf1, Paf1/RNA polymerase II complex component, homolog

RTF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RTF1	Q92541	PAF1	Homo sapiens	Q8N7H5	Anti Tag CoIP	20178742
Intra	RTF1	Q92541	PAF1	Homo sapiens	Q8N7H5	TAP	24981860
Intra	RTF1	Q92541	PAF1	Homo sapiens	Q8N7H5	Anti Bait CoIP	16024656
Intra	RTF1	Q92541	CDC73	Homo sapiens	Q6P1J9	Anti Bait CoIP	16024656
Intra	RTF1	Q92541	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	20178742

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency 47

Congenital Disorder Of Glycosylation Type Ii	CDG2E
Congenital Disorder Of Glycosylation Type Iie	IMD47
Cdg2s	Cdg Iis
Cdgiis	Immunodeficiency And Hepatopathy With Or Without Neurologic Features
Congenital Disorder Of Glycosylation, Type Ii	CDG1I
Congenital Disorder Of Glycosylation, Type Iie	Cdg Iie
Congenital Disorder Of Glycosylation Type 2e	Congenital Disorder Of Glycosylation, Type Iis
Cdg Ii	Cdgii
Cdgiie	Carbohydrate Deficient Glycoprotein Syndrome Type Iie
Cdg Syndrome Type Iie	Congenital Disorder Of Glycosylation Ii
Congenital Disorder Of Glycosylation 1i	Cdg-Iie
Alg2-Cdg	Cdg-Ii
Glycosylation, Congenital Disorder Of, Type Ii	Cdgiide
Congenital Disorder Of Glycosylation Type Iis	Cog7-Cdg
Cdg Syndrome Type Ii	Carbohydrate Deficient Glycoprotein Syndrome Type Ii
Congenital Disorder Of Glycosylation Type 1i	Mannosyltransferase 2 Deficiency
Congenital Disorder Of Glycosylation 2e	Congenital Disorder Of Glycosylation 2s
Congenital Disorders Of Glycosylation Type Ii	Glycosylation, Congenital Disorder Of, Type Iie
Immunodeficiency, Type 47	Congenital Disorder Of Glycosylation Type 2a

Cholestasis, Intrahepatic, Of Pregnancy, 1

ICP1	Intrahepatic Cholestasis Of Pregnancy 1
Cholestasis, Pregnancy-Related, 1	Pregnancy Related Cholestasis 1
Cholestasis Of Pregnancy, Intrahepatic 1	Obstetric Cholestasis
Pregnancy-Related Cholestasis	Recurrent Intrahepatic Cholestasis Of Pregnancy
Cholestasis, Intrahepatic, Of Pregnancy, Type 1	Cholestasis Of Pregnancy

Hereditary Wilms' Tumor

Hereditary Wilms Tumor	Hereditary Wilms Tumour
Hereditary Wilms' Tumour	Wt1

Malignant Fibrous Histiocytoma Of Bone

Malignant Fibrous Histiocytoma Of The Bone

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12318	RTF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RTF1	VGNC	VGNC:45787
Bos taurus	RTF1	VGNC	VGNC:34195
Felis catus	RTF1	VGNC	VGNC:64806
Mus musculus	RTF1	MGD	MGI:1309480
Macaca mulatta	RTF1	VGNC	VGNC:77119
Rattus norvegicus	RTF1	RGD	RGD:1310654

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