PASK - PAS domain containing serine/threonine kinase Gene

Homo sapiens

Also known as STK37; PASKIN

Gene ID: 23178 | Gene type: protein coding

About PASK

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,106,099-241,150,347 (from NCBI)

This gene has 16 transcripts (splice variants) and 198 orthologues. Broad expression in testis (RPKM 7.9), lymph node (RPKM 6.8) and 21 other tissues.

Summary

This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of Insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

PASK Products(5)

mRNA	Protein	Name
NM_001252119.2	NP_001239048.1	PAS domain-containing serine/threonine-protein kinase isoform 1
NM_001252120.2	NP_001239049.1	PAS domain-containing serine/threonine-protein kinase isoform 2
NM_001252122.2	NP_001239051.1	PAS domain-containing serine/threonine-protein kinase isoform 3
NM_001252124.2	NP_001239053.1	PAS domain-containing serine/threonine-protein kinase isoform 4
NM_015148.4	NP_055963.2	PAS domain-containing serine/threonine-protein kinase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	21418524	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16275910	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	16275910	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of glycogen biosynthetic process	IDA IDA: Inferred from direct assay	16275910	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	20943661	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	16275910	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17595531	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17595531	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PASK Protein Structure

PAS_9

Pkinase

0
300
600
900
1200
1323 a.a.

Protein Preferred Names

Protein Names

PAS domain-containing serine/threonine-protein kinase

per-arnt-sim (PAS) domain kinase

PASK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PASK	Q96RG2	RPS6	Homo sapiens	P62753	Protein Kinase Assay	21418524
Intra	PASK	Q96RG2	CREB1	Homo sapiens	P16220	Protein Kinase Assay	21418524
Intra	PASK	Q96RG2	PHKB	Homo sapiens	Q93100	Protein Kinase Assay	21418524
Cross	PASK	Q96RG2	CACNA1S	Oryctolagus cuniculus	P07293	Peptide Array	21418524
Cross	PASK	Q96RG2	TNNI3	Oryctolagus cuniculus	P02646	Peptide Array	21418524
Cross	PASK	Q96RG2	GFAP	Bos taurus	Q28115	Peptide Array	21418524

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Niemann-Pick Disease, Type C1

Niemann-Pick Disease, Type C	NPC1
Niemann-Pick Disease, Type D	Niemann-Pick Disease Type C1
Niemann-Pick Disease With Cholesterol Esterification Block	Niemann-Pick Disease, Subacute Juvenile Form
Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia	Npc
Niemann-Pick Disease, Chronic Neuronopathic Form	Niemann-Pick Disease Without Sphingomyelinase Deficiency
Niemann-Pick Disease Type C	Niemann-Pick Disease Type D
Niemann-Pick C1 Disease	Niemann-Pick Disease C1
Niemann-Pick Disease Chronic Neuronopathic Form	Niemann-Pick Disease Nova Scotian Type
Niemann-Pick Disease Subacute Juvenile Form	Niemann-Pick Disease Type Ii
Niemann-Picks Disease Type C

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129571	BioE-1115	Inhibitor	99.56%	Unkown
HY-152247	DDO3711	Inhibitor	/	Unkown
HY-RS10078	PASK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PASK	MGD	MGI:2155936
Felis catus	PASK	VGNC	VGNC:64048
Canis familiaris	PASK	VGNC	VGNC:44270
Macaca mulatta	PASK	VGNC	VGNC:75638
Rattus norvegicus	PASK	RGD	RGD:1306146
Bos taurus	PASK	VGNC	VGNC:58397
Others	PASK	NCBI

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