RPS6 - ribosomal protein S6 Gene

Homo sapiens

Also known as S6

Gene ID: 6194 | Gene type: protein coding

About RPS6

Cytogenetic location: 9p22.1 Genomic coordinates (GRCh38): 9:19,375,715-19,380,236 (from NCBI)

This gene has 5 transcripts (splice variants) and 184 orthologues. Ubiquitous expression in ovary (RPKM 2180.7), bone marrow (RPKM 1555.2) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS6 Products(1)

mRNA	Protein	Name
NM_001010.3	NP_001001.2	40S ribosomal protein S6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16314389	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21418524	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	8706699	GOA
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	18697920	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in TOR signaling	IDA IDA: Inferred from direct assay	16428328	GOA
involved in cytoplasmic translation	IDA IDA: Inferred from direct assay	8706699	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	18362888	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17220279	GOA
involved in rRNA processing	IMP IMP: Inferred from mutant phenotype	18697920	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA
involved in ribosomal small subunit biogenesis	IMP IMP: Inferred from mutant phenotype	18697920	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell body	IDA IDA: Inferred from direct assay	15121898	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	8706699	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
located in dendrite	IDA IDA: Inferred from direct assay	15121898	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	8590812	GOA
located in nucleus	IDA IDA: Inferred from direct assay	2334893	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	18809582	GOA
part of small ribosomal subunit	IDA IDA: Inferred from direct assay	15590835	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS6 Protein Structure

Ribosomal_S6e

0
100
200
249 a.a.

Protein Preferred Names

Protein Names

40S ribosomal protein S6

phosphoprotein NP33

RPS6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPS6	P62753	PASK	Homo sapiens	Q96RG2	Peptide Array	21418524
Intra	RPS6	P62753	PASK	Homo sapiens	Q96RG2	Protein Kinase Assay	21418524
Cross	RPS6	P62753	N	SARS-CoV-2	P0DTC9	Y2H Array	36217030
Intra	RPS6	P62753	NCBP1	Homo sapiens	Q09161	Anti Tag CoIP	18423201
Intra	RPS6	P62753	NCBP1	Homo sapiens	Q09161	Anti Bait CoIP	18423201
Intra	RPS6	P62753	NPM1	Homo sapiens	P06748	Crosslink	30021884
Intra	RPS6	P62753	NPM1	Homo sapiens	P06748	BioID	29568061

Cross: Cross-species interaction Intra: Intraspecies interaction

RPS6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80885	RPS6 Antibody (YA677)	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey

Related Diseases

Diseases

Alias

Tuberous Sclerosis

Tuberous Sclerosis Syndrome	Bourneville'S Disease
Epiloia	Cerebral Sclerosis
Tuberose Sclerosis	Tuberous Sclerosis 1
Bourneville Disease	Bourneville Phakomatosis
Pringle'S Disease

Lymphangioleiomyomatosis

Lymphangiomyomatosis	LAM
Lung Lymphangioleiomyomatosis	Pulmonary Lymphangioleiomyomatosis
Lymphangioleiomyomatosis, Somatic	Lymphangio-Myomatosis

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Muscle Hypertrophy

MSLHP	Hypertrophy
Hypertrophy, Muscle

Motor Neuron Disease

Anterior Horn Cell Disease	Motor Neuron Diseases
Mnd - [Motor Neurone Disease]	Lou Gehrig Disease
Creeping Palsy	Creeping Paralysis
Bulbar Motor Neuron Disease	Bulbar Syndrome
Anterior Horn Cell Disorder	Hereditary Motor Neuron Disease

Subependymal Glioma

Mixed Subependymoma-Ependymoma	Subependymal Astrocytoma
Who Grade I Ependymal Tumor	Glioma, Subependymal

Kidney Angiomyolipoma

Angiomyolipoma Of Kidney

Renal Angiomyolipoma

Diamond-Blackfan Anemia 6

DBA6	Aase-Smith Syndrome Ii
Aase Syndrome	Aase Smith Syndrome 2
Rpl5-Related Diamond-Blackfan Anemia	Anemia, Diamond-Blackfan, Type 6
Diamond-Blackfan Anemia 1

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Pyriform Sinus Cancer

Malignant Neoplasm Of Pyriform Fossa	Malignant Neoplasm Of The Pyriform Fossa
Malignant Tumor Of Pyriform Fossa

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (32)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123919	TL13-112	Inhibitor	98.15%	Unkown
HY-148062	RSS0680		98.03%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-122582	TL13-12	Inhibitor	98.06%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-RS12247	RPS6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-148065	FMF-06-098-1		/	Unkown
HY-150643	RSK2-IN-2	Inhibitor	/	Unkown
HY-150717	RSK2-IN-3	Inhibitor	/	Unkown
HY-161874	RPS6-IN-1		/	Unkown
HY-RS12248	RPS6KA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12249	Rps6ka1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12250	Rps6ka1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12251	RPS6KA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12252	Rps6ka2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12253	Rps6ka2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12254	RPS6KA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12255	Rps6ka3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12256	Rps6ka3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12257	RPS6KA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12258	RPS6KA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12259	RPS6KA6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12260	Rps6ka6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12261	Rps6ka6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12262	RPS6KB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12263	Rps6kb1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12264	Rps6kb1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12265	RPS6KB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12266	Rps6kb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12267	Rps6kb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12268	RPS6KC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-50733	CX-5011 free base		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPS6	MGD	MGI:98159
Felis catus	RPS6	VGNC	VGNC:97612
Rattus norvegicus	RPS6	RGD	RGD:3602
Others	RPS6	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.