RGL1 - ral guanine nucleotide dissociation stimulator like 1 Gene

Homo sapiens

Also known as RGL

Gene ID: 23179 | Gene type: protein coding

About RGL1

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:183,636,109-183,928,532 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 24 paralogues. Ubiquitous expression in spleen (RPKM 23.7), brain (RPKM 15.5) and 22 other tissues.

Summary

Predicted to be involved in regulation of catalytic activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RGL1 Products(5)

mRNA	Protein	Name
NM_001297669.3	NP_001284598.1	ral guanine nucleotide dissociation stimulator-like 1 isoform 2
NM_001297670.3	NP_001284599.1	ral guanine nucleotide dissociation stimulator-like 1 isoform 2
NM_001297671.3	NP_001284600.1	ral guanine nucleotide dissociation stimulator-like 1 isoform 3
NM_001297672.3	NP_001284601.1	ral guanine nucleotide dissociation stimulator-like 1 isoform 4
NM_015149.6	NP_055964.3	ral guanine nucleotide dissociation stimulator-like 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20936779	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGL1 Protein Structure

RasGEF_N

RasGEF

0
200
400
600
768 a.a.

Protein Preferred Names

Protein Names

ral guanine nucleotide dissociation stimulator-like 1

ralGDS-like 1

RGL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RGL1	Q9NZL6	HRAS	Homo sapiens	P01112	Y2H Pooling	20936779
Intra	RGL1	Q9NZL6	HRAS	Homo sapiens	P01112	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nutritional Optic Neuropathy

Abnormality Of Glucagon Secretion

Glucagon Secretion Abnormality

Abnormality Of Secretion Of Glucagon

Toxic Optic Neuropathy

Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia	XLN
SCNX	Severe Congenital Neutropenia X-Linked
Neutropenia, Congenital, Severe, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11890	RGL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RGL1	MGD	MGI:107484
Rattus norvegicus	RGL1	RGD	RGD:1308947
Felis catus	RGL1	VGNC	VGNC:64590
Bos taurus	RGL1	VGNC	VGNC:33903
Macaca mulatta	RGL1	VGNC	VGNC:76868
Canis familiaris	RGL1	VGNC	VGNC:45512

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