RCOR1 - REST corepressor 1 Gene

Homo sapiens

Also known as RCOR; COREST

Gene ID: 23186 | Gene type: protein coding

About RCOR1

Cytogenetic location: 14q32.31-q32.32 Genomic coordinates (GRCh38): 14:102,592,649-102,730,561 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 19.5), esophagus (RPKM 14.2) and 25 other tissues.

Summary

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]

RCOR1 Products(1)

mRNA	Protein	Name
NM_015156.4	NP_055971.2	REST corepressor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10449787	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10449787	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of DNA repair complex	IDA IDA: Inferred from direct assay	24217620	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10734093	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	10734093	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCOR1 Protein Structure

ELM2

Myb_DNA-binding

0
100
200
300
400
482 a.a.

Protein Preferred Names

Protein Names

REST corepressor 1

RCOR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RCOR1	Q9UKL0	ZNF516	Homo sapiens	Q92618	Anti Tag CoIP	33961781
Intra	RCOR1	Q9UKL0	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	12192000
Intra	RCOR1	Q9UKL0	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	17939992
Intra	RCOR1	Q9UKL0	SMARCE1	Homo sapiens	Q969G3-2	Y2H	12192000
Intra	RCOR1	Q9UKL0	KDM1A	Homo sapiens	O60341	Anti Tag CoIP	33961781
Intra	RCOR1	Q9UKL0	KDM1A	Homo sapiens	O60341	Anti Bait CoIP	19703393

Cross: Cross-species interaction Intra: Intraspecies interaction

RCOR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82068	CoREST Antibody (YA1813)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11791	RCOR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RCOR1	VGNC	VGNC:45446
Rattus norvegicus	RCOR1	RGD	RGD:7505493
Mus musculus	RCOR1	MGD	MGI:106340
Bos taurus	RCOR1	VGNC	VGNC:33834
Macaca mulatta	RCOR1	VGNC	VGNC:76752
Felis catus	RCOR1	VGNC	VGNC:64551

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