UBXN4 - UBX domain protein 4 Gene

Homo sapiens

Also known as UBXD2; UBXDC1; erasin

Gene ID: 23190 | Gene type: protein coding

About UBXN4

Cytogenetic location: 2q21.3 Genomic coordinates (GRCh38): 2:135,741,855-135,785,056 (from NCBI)

This gene has 8 transcripts (splice variants), 168 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 49.4), gall bladder (RPKM 38.6) and 25 other tissues.

Summary

UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008]

UBXN4 Products(1)

mRNA	Protein	Name
NM_014607.4	NP_055422.1	UBX domain-containing protein 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18775313	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	19822669	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBXN4 Protein Structure

UBX

0
100
200
300
400
508 a.a.

Protein Preferred Names

Protein Names

UBX domain-containing protein 4

UBX domain containing 2

UBXN4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBXN4	Q92575	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	UBXN4	Q92575	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	UBXN4	Q92575	UBE4A	Homo sapiens	Q14139	Pull Down	22119785
Intra	UBXN4	Q92575	UBE4A	Homo sapiens	Q14139	Anti Tag CoIP	33961781
Intra	UBXN4	Q92575	VCP	Homo sapiens	P55072	BRET	29997244
Intra	UBXN4	Q92575	VCP	Homo sapiens	P55072	Lumier	29997244
Intra	UBXN4	Q92575	VCP	Homo sapiens	P55072	Anti Tag CoIP	18775313
Intra	UBXN4	Q92575	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	25416956
Intra	UBXN4	Q92575	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	UBXN4	Q92575	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	UBXN4	Q92575	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	UBXN4	Q92575	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 1

Ibmpfd1	Msp1
Multisystem Proteinopathy 1

Martsolf Syndrome 1

Martsolf Syndrome	Cataract-Intellectual Disability-Hypogonadism Syndrome
MARTS1	Marts
Cataract-Mental Retardation-Hypogonadism	Martsolf

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15397	UBXN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UBXN4	RGD	RGD:1307451
Bos taurus	UBXN4	VGNC	VGNC:36627
Mus musculus	UBXN4	MGD	MGI:1915062
Canis familiaris	UBXN4	VGNC	VGNC:48100
Felis catus	UBXN4	VGNC	VGNC:80400
Macaca mulatta	UBXN4	VGNC	VGNC:78968

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