2. Gene
  3. ATG4B - autophagy related 4B cysteine peptidase Gene

ATG4B - autophagy related 4B cysteine peptidase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APG4B; AUTL1; HsAPG4B

Gene ID: 23192 | Gene type: protein coding

About ATG4B

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,637,693-241,673,857 (from NCBI)

This gene has 26 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 14.5), duodenum (RPKM 12.3) and 25 other tissues.

Summary

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of Autophagy have been described in some malignant tumors, and a role for Autophagy in controlling the unregulated cell growth linked to Cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

ATG4B Products(2)

mRNA Protein Name
NM_013325.5 NP_037457.3 cysteine protease ATG4B isoform a
NM_178326.3 NP_847896.1 cysteine protease ATG4B isoform b

ATG4B Protein Structure

Peptidase_C54

Peptidase_C54: Peptidase family C54 (38 - 337)

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  • 393 a.a.
Protein Preferred Names Protein Names

cysteine protease ATG4B

APG4 autophagy 4 homolog B

Related Diseases

Diseases Alias
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125169 NSC 185058 Inhibitor 99.46% Unkown
HY-112818 S130 99.43% Unkown
HY-112711 LV-320 Inhibitor ≥95.0% Unkown
HY-W287569 STK683963 99.41% Unkown
HY-144636 Atg4B-IN-2 Inhibitor 98.03% Unkown
HY-163193 MJO445 Inhibitor / Unkown
HY-RS01149 ATG4B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ATG4B VGNC VGNC:60003
Canis familiaris ATG4B VGNC VGNC:49762
Macaca mulatta ATG4B VGNC VGNC:70104
Bos taurus ATG4B VGNC VGNC:26258
Mus musculus ATG4B MGD MGI:1913865
Rattus norvegicus ATG4B RGD RGD:1309664