ATG4B - autophagy related 4B cysteine peptidase Gene

Homo sapiens

Also known as APG4B; AUTL1; HsAPG4B

Gene ID: 23192 | Gene type: protein coding

About ATG4B

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,637,693-241,673,857 (from NCBI)

This gene has 26 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 14.5), duodenum (RPKM 12.3) and 25 other tissues.

Summary

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of Autophagy have been described in some malignant tumors, and a role for Autophagy in controlling the unregulated cell growth linked to Cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

ATG4B Products(2)

mRNA	Protein	Name
NM_013325.5	NP_037457.3	cysteine protease ATG4B isoform a
NM_178326.3	NP_847896.1	cysteine protease ATG4B isoform b

ATG4B Protein Structure

Peptidase_C54

0
100
200
300
393 a.a.

Protein Preferred Names

Protein Names

cysteine protease ATG4B

APG4 autophagy 4 homolog B

ATG4B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ATG4B	Q9Y4P1	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	ATG4B	Q9Y4P1	MAP1LC3B	Homo sapiens	Q9GZQ8	Protease Assay	19322194
Intra	ATG4B	Q9Y4P1	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	ATG4B	Q9Y4P1	MAP1LC3B	Homo sapiens	Q9GZQ8	X-Ray Diffraction	19322194
Intra	ATG4B	Q9Y4P1	MAP1LC3B	Homo sapiens	Q9GZQ8	BioID	34524948
Intra	ATG4B	Q9Y4P1	MAP1LC3B	Homo sapiens	Q9GZQ8	NMR	19322194
Intra	ATG4B	Q9Y4P1	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	ATG4B	Q9Y4P1	GABARAP	Homo sapiens	O95166	Anti Tag CoIP	20562859
Intra	ATG4B	Q9Y4P1	GABARAP	Homo sapiens	O95166	Anti Tag CoIP	33961781
Intra	ATG4B	Q9Y4P1	GABARAPL2	Homo sapiens	P60520	Anti Tag CoIP	20562859
Intra	ATG4B	Q9Y4P1	GABARAPL2	Homo sapiens	P60520	Anti Tag CoIP	33961781
Intra	ATG4B	Q9Y4P1	GABARAPL2	Homo sapiens	P60520	BioID	34524948
Intra	ATG4B	Q9Y4P1	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	ATG4B	Q9Y4P1	GABARAPL2	Homo sapiens	P60520	Y2H	21900206
Intra	ATG4B	Q9Y4P1	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	ATG4B	Q9Y4P1	GABARAPL1	Homo sapiens	Q9H0R8	Anti Tag CoIP	35271311
Intra	ATG4B	Q9Y4P1	GABARAPL1	Homo sapiens	Q9H0R8	Anti Tag CoIP	20562859
Intra	ATG4B	Q9Y4P1	GABARAPL1	Homo sapiens	Q9H0R8	Anti Tag CoIP	33961781
Cross	ATG4B	Q9Y4P1	a0a0h3lac5_mycte	Mycobacterium tuberculosis	A0A0H3LAC5	Anti Bait CoIP	30118682

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125169	NSC 185058	Inhibitor	99.46%	Unkown
HY-112818	S130		99.43%	Unkown
HY-112711	LV-320	Inhibitor	≥95.0%	Unkown
HY-W287569	STK683963		99.41%	Unkown
HY-144636	Atg4B-IN-2	Inhibitor	98.03%	Unkown
HY-163193	MJO445	Inhibitor	/	Unkown
HY-RS01149	ATG4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATG4B	VGNC	VGNC:60003
Canis familiaris	ATG4B	VGNC	VGNC:49762
Macaca mulatta	ATG4B	VGNC	VGNC:70104
Bos taurus	ATG4B	VGNC	VGNC:26258
Mus musculus	ATG4B	MGD	MGI:1913865
Rattus norvegicus	ATG4B	RGD	RGD:1309664

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