BOP1 - BOP1 ribosomal biogenesis factor Gene

Homo sapiens

Gene ID: 23246 | Gene type: protein coding

About BOP1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,262,045-144,291,438 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele and 182 orthologues. Ubiquitous expression in testis (RPKM 10.2), appendix (RPKM 9.2) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in regulation of cell cycle; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Located in chromosome; nucleolus; and nucleoplasm. Part of PeBoW complex. [provided by Alliance of Genome Resources, Apr 2022]

BOP1 Products(1)

mRNA	Protein	Name
NM_015201.5	NP_056016.1	ribosome biogenesis protein BOP1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16043514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP IMP: Inferred from mutant phenotype	17353269	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	16043514	GOA
involved in regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	24120868	GOA
involved in ribosomal large subunit assembly	IMP IMP: Inferred from mutant phenotype	24120868	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PeBoW complex	IDA IDA: Inferred from direct assay	16043514	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	18809582	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BOP1 Protein Structure

BOP1NT

WD40

0
200
400
600
746 a.a.

Protein Preferred Names

Protein Names

ribosome biogenesis protein BOP1

block of proliferation 1

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01576	BOP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BOP1	VGNC	VGNC:70315
Felis catus	BOP1	VGNC	VGNC:60149
Canis familiaris	BOP1	VGNC	VGNC:38498
Mus musculus	BOP1	MGD	MGI:1334460
Bos taurus	BOP1	VGNC	VGNC:26540
Rattus norvegicus	BOP1	RGD	RGD:1310589

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