WDR12 - WD repeat domain 12 Gene

Homo sapiens

Also known as YTM1

Gene ID: 55759 | Gene type: protein coding

About WDR12

Cytogenetic location: 2q33.2 Genomic coordinates (GRCh38): 2:202,874,261-202,911,673 (from NCBI)

This gene has 9 transcripts (splice variants), 218 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 5.2), kidney (RPKM 3.9) and 25 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008]

WDR12 Products(2)

mRNA	Protein	Name
NM_001371664.1	NP_001358593.1	ribosome biogenesis protein WDR12 isoform 2
NM_018256.4	NP_060726.3	ribosome biogenesis protein WDR12 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16043514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP IMP: Inferred from mutant phenotype	16043514	GOA
involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP IMP: Inferred from mutant phenotype	16043514	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	16043514	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PeBoW complex	IDA IDA: Inferred from direct assay	16043514	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	16043514	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	16043514	GOA
part of preribosome, large subunit precursor	IDA IDA: Inferred from direct assay	17353269	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR12 Protein Structure

NLE

WD40

0
100
200
300
400
423 a.a.

Protein Preferred Names

Protein Names

ribosome biogenesis protein WDR12

WD repeat-containing protein 12

WDR12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WDR12	Q9GZL7	BOP1	Homo sapiens	Q14137	Anti Tag CoIP	35271311
Intra	WDR12	Q9GZL7	PES1	Homo sapiens	O00541	Anti Tag CoIP	35271311
Intra	WDR12	Q9GZL7	PES1	Homo sapiens	O00541	Anti Bait CoIP	16043514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15762	WDR12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WDR12	MGD	MGI:1927241
Rattus norvegicus	WDR12	RGD	RGD:735072
Bos taurus	WDR12	VGNC	VGNC:36882
Canis familiaris	WDR12	VGNC	VGNC:48351
Felis catus	WDR12	VGNC	VGNC:67015

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