MGA - MAX dimerization protein MGA Gene

Homo sapiens

Also known as MAD5; MXD5

Gene ID: 23269 | Gene type: protein coding

About MGA

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,621,224-41,769,940 (from NCBI)

This gene has 16 transcripts (splice variants), 293 orthologues and 16 paralogues. Ubiquitous expression in ovary (RPKM 5.9), testis (RPKM 5.5) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to Leukemia Inhibitory Factor. Part of MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022]

MGA Products(9)

mRNA	Protein	Name
NM_001080541.3	NP_001074010.2	MAX gene-associated protein isoform 2
NM_001164273.2	NP_001157745.1	MAX gene-associated protein isoform 1
NM_001400225.1	NP_001387154.1	MAX gene-associated protein isoform 3
NM_001400242.1	NP_001387171.1	MAX gene-associated protein isoform 4
NM_001400243.1	NP_001387172.1	MAX gene-associated protein isoform 5
NM_001400244.1	NP_001387173.1	MAX gene-associated protein isoform 5
NM_001400245.1	NP_001387174.1	MAX gene-associated protein isoform 5
NM_001400246.1	NP_001387175.1	MAX gene-associated protein isoform 5
NM_001400247.1	NP_001387176.1	MAX gene-associated protein isoform 5

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20936779	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MLL1 complex	IDA IDA: Inferred from direct assay	15960975	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGA Protein Structure

T-box

HLH

0
500
1000
1500
2000
2500
3065 a.a.

Protein Preferred Names

Protein Names

MAX gene-associated protein

MAX dimerization protein 5

MGA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MGA	Q8IWI9	MAX	Homo sapiens	P61244	Y2H Pooling	20936779
Intra	MGA	Q8IWI9	CBX3	Homo sapiens	Q13185	Y2H Pooling	20936779

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spindle Cell Sarcoma

Sarcoma	Sarcoma Spindle Cell
Sarcoma, Spindle Cell	Sarcoma - Category

Blue Toe Syndrome

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Psoriasis 5

PSORS5	Psoriasis Susceptibility 5
Psoriasis 5, Susceptibility To

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Psoriasis 3

PSORS3	Psoriasis Susceptibility 3
Psoriasis 3, Susceptibility To

Cholesterol Embolism

Atheroembolism	Trash Foot
Cholesterol Crystal Embolism	Purple Toe Syndrome
Warfarin Blue Toe Syndrome	Embolism, Cholesterol
Cholesterol Embolus Syndrome

Cataract 37

CTRCT37	Cca5
Cataract, Congenital, Cerulean Type, 5	Cataract 37, Autosomal Dominant
Congenital Cataract Cerulean Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99222	Teplizumab		≥99.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111614	Melengestrol acetate	Activator	99.76%	Unkown
HY-RS08395	MGA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MGA	VGNC	VGNC:31445
Canis familiaris	MGA	VGNC	VGNC:43210
Felis catus	MGA	VGNC	VGNC:63486
Rattus norvegicus	MGA	RGD	RGD:1561597
Mus musculus	MGA	MGD	MGI:1352483
Macaca mulatta	MGA	VGNC	VGNC:84390
Others	MGA	NCBI

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