MGRN1 - mahogunin ring finger 1 Gene

Homo sapiens

Also known as RNF156

Gene ID: 23295 | Gene type: protein coding

About MGRN1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,624,826-4,690,972 (from NCBI)

This gene has 18 transcripts (splice variants), 219 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 8.9), brain (RPKM 8.4) and 25 other tissues.

Summary

Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin Ligase activity in vitro.[supplied by OMIM, Apr 2004]

MGRN1 Products(4)

mRNA	Protein	Name
NM_001142289.3	NP_001135761.2	E3 ubiquitin-protein ligase MGRN1 isoform 2
NM_001142290.3	NP_001135762.1	E3 ubiquitin-protein ligase MGRN1 isoform 3
NM_001142291.3	NP_001135763.2	E3 ubiquitin-protein ligase MGRN1 isoform 4
NM_015246.4	NP_056061.1	E3 ubiquitin-protein ligase MGRN1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17229889	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	17229889	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	17229889	GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	19737927	GOA
involved in protein monoubiquitination	IMP IMP: Inferred from mutant phenotype	17229889	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17229889	GOA
located in early endosome	IDA IDA: Inferred from direct assay	17229889	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17229889	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19737927	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGRN1 Protein Structure

zf-C3HC4_3

0
100
200
300
400
500
552 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase MGRN1

RING finger protein 156

MGRN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MGRN1	O60291	TSG101	Homo sapiens	Q99816	Y2H Prey Pooling	25416956
Intra	MGRN1	O60291	TSG101	Homo sapiens	Q99816	Y2H Array	19549727
Intra	MGRN1	O60291	TSG101	Homo sapiens	Q99816	Validated Y2H	25416956
Intra	MGRN1	O60291	TSG101	Homo sapiens	Q99816	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Gerstmann-Straussler Disease

Gerstmann-Straussler-Scheinker Disease	Gerstmann-Straussler-Scheinker Syndrome
Prion Dementia	Cerebral Amyloid Angiopathy, Prnp-Related
GSD	Gss
Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In Cns	Amyloidosis, Cerebral, With Spongiform Encephalopathy
Subacute Spongiform Encephalopathy, Gerstmann-Straussler Type	Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type
Amyloidosis Cerebral With Spongiform Encephalopathy	Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In The Central Nervous System
Encephalopathy Subacute Spongiform Gerstmann-Straussler Type	Gssd
Gerstmann Straussler Scheinker Syndrome	Cerebral Amyloidosis With Spongiform Encephalopathy
Subacute Spongiform Encephalopathy Gerstmann-Straussler Type	Gluthathione Synthetase Deficiency
Gerstmann Straussler Syndrome

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08415	MGRN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MGRN1	VGNC	VGNC:43214
Rattus norvegicus	MGRN1	RGD	RGD:1311862
Bos taurus	MGRN1	VGNC	VGNC:97285
Mus musculus	MGRN1	MGD	MGI:2447670
Macaca mulatta	MGRN1	VGNC	VGNC:74542
Felis catus	MGRN1	VGNC	VGNC:63491

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