JADE2 - jade family PHD finger 2 Gene

Homo sapiens

Also known as PHF15; JADE-2

Gene ID: 23338 | Gene type: protein coding

About JADE2

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,523,952-134,583,227 (from NCBI)

This gene has 17 transcripts (splice variants), 212 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 11.1), ovary (RPKM 11.0) and 24 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Involved in histone acetylation. Located in nucleoplasm. Part of Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

JADE2 Products(8)

mRNA	Protein	Name
NM_001289984.2	NP_001276913.1	E3 ubiquitin-protein ligase Jade-2 isoform 1
NM_001289985.2	NP_001276914.1	E3 ubiquitin-protein ligase Jade-2 isoform 2
NM_001308143.2	NP_001295072.1	E3 ubiquitin-protein ligase Jade-2 isoform 4
NM_001388185.1	NP_001375114.1	E3 ubiquitin-protein ligase Jade-2 isoform 4
NM_001388186.1	NP_001375115.1	E3 ubiquitin-protein ligase Jade-2 isoform 4
NM_001388187.1	NP_001375116.1	E3 ubiquitin-protein ligase Jade-2 isoform 4
NM_001388188.1	NP_001375117.1	E3 ubiquitin-protein ligase Jade-2 isoform 5
NM_015288.6	NP_056103.4	E3 ubiquitin-protein ligase Jade-2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to histone H3K14 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
enables histone H4K12 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
NOT enables histone H4K16 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
enables histone H4K5 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
enables histone H4K8 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20211142	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	16387653	GOA
involved in regulation of DNA replication	IDA IDA: Inferred from direct assay	16387653	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	16387653	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	16387653	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	16387653	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JADE2 Protein Structure

EPL1

PHD_2

zf-HC5HC2H_2

0
200
400
600
790 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase Jade-2

PHD finger protein 15

JADE2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	JADE2	Q9NQC1	ING4	Homo sapiens	Q9UNL4	Y2H Array	20211142
Intra	JADE2	Q9NQC1	ING4	Homo sapiens	Q9UNL4	Anti Tag CoIP	33961781
Intra	JADE2	Q9NQC1	ING5	Homo sapiens	Q8WYH8	Y2H Prey Pooling	25416956
Intra	JADE2	Q9NQC1	ING5	Homo sapiens	Q8WYH8	Anti Tag CoIP	33961781
Intra	JADE2	Q9NQC1	ING5	Homo sapiens	Q8WYH8	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07010	JADE2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	JADE2	VGNC	VGNC:73641
Bos taurus	JADE2	VGNC	VGNC:30359
Mus musculus	JADE2	MGD	MGI:1924151
Rattus norvegicus	JADE2	RGD	RGD:1309152
Felis catus	JADE2	VGNC	VGNC:62996
Canis familiaris	JADE2	VGNC	VGNC:42170

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