ING5 - inhibitor of growth family member 5 Gene

Homo sapiens

Also known as p28ING5

Gene ID: 84289 | Gene type: protein coding

About ING5

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,687,020-241,729,478 (from NCBI)

This gene has 13 transcripts (splice variants), 216 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 3.6), skin (RPKM 3.2) and 25 other tissues.

Summary

This gene encodes a tumor suppressor protein that inhibits cell growth and induces Apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]

ING5 Products(3)

mRNA	Protein	Name
NM_001330161.2	NP_001317090.1	inhibitor of growth protein 5 isoform 2
NM_001330162.2	NP_001317091.1	inhibitor of growth protein 5 isoform 3
NM_032329.6	NP_115705.2	inhibitor of growth protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	16728974	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12750254	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA replication-dependent chromatin disassembly	IDA IDA: Inferred from direct assay	16387653	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12750254	GOA
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	21750715	GOA
involved in negative regulation of growth	IDA IDA: Inferred from direct assay	12750254	GOA
acts upstream of or within positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	21750715	GOA
involved in protein acetylation	IDA IDA: Inferred from direct assay	12750254	GOA
involved in regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	16387653	GOA
involved in regulation of DNA replication	IDA IDA: Inferred from direct assay	16387653	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18794358	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	16387653	GOA
involved in regulation of cell growth	IDA IDA: Inferred from direct assay	22144582	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MOZ/MORF histone acetyltransferase complex	IDA IDA: Inferred from direct assay	16387653	GOA
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	16387653	GOA
part of histone acetyltransferase complex	IPI IPI: Inferred from physical interaction	16387653	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	16387653	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18794358	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ING5 Protein Structure

ING

PHD

0
100
200
240 a.a.

Protein Preferred Names

Protein Names

inhibitor of growth protein 5

ING5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ING5	Q8WYH8	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	ING5	Q8WYH8	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	ING5	Q8WYH8	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	ING5	Q8WYH8	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	32296183
Intra	ING5	Q8WYH8	MBIP	Homo sapiens	Q9NS73-5	Validated Y2H	25416956
Intra	ING5	Q8WYH8	MBIP	Homo sapiens	Q9NS73-5	Y2H Array	25416956
Intra	ING5	Q8WYH8	ICA1	Homo sapiens	Q05084	Y2H Prey Pooling	25416956
Intra	ING5	Q8WYH8	ICA1	Homo sapiens	Q05084	Y2H Array	25416956
Intra	ING5	Q8WYH8	ICA1	Homo sapiens	Q05084	Validated Y2H	25416956
Intra	ING5	Q8WYH8	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
Intra	ING5	Q8WYH8	BRPF1	Homo sapiens	P55201-2	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	BRPF1	Homo sapiens	P55201-2	Y2H Array	32296183
Intra	ING5	Q8WYH8	JADE2	Homo sapiens	A0A0C4DFT8	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	JADE2	Homo sapiens	A0A0C4DFT8	Y2H Array	32296183
Intra	ING5	Q8WYH8	GGA1	Homo sapiens	Q9UJY5-4	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	GGA1	Homo sapiens	Q9UJY5-4	Validated Y2H	32296183
Intra	ING5	Q8WYH8	GGA1	Homo sapiens	Q9UJY5-4	Y2H Array	32296183
Intra	ING5	Q8WYH8	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	ING5	Q8WYH8	WASF1	Homo sapiens	Q92558	Validated Y2H	32296183
Intra	ING5	Q8WYH8	JADE2	Homo sapiens	Q9NQC1	Validated Y2H	25416956
Intra	ING5	Q8WYH8	JADE2	Homo sapiens	Q9NQC1	Anti Tag CoIP	33961781
Intra	ING5	Q8WYH8	JADE2	Homo sapiens	Q9NQC1	TAP	24981860
Intra	ING5	Q8WYH8	C3orf62	Homo sapiens	Q6ZUJ4	Y2H Array	25416956
Intra	ING5	Q8WYH8	C3orf62	Homo sapiens	Q6ZUJ4	Validated Y2H	25416956
Intra	ING5	Q8WYH8	THAP6	Homo sapiens	Q8TBB0	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	THAP6	Homo sapiens	Q8TBB0	Y2H Array	32296183
Intra	ING5	Q8WYH8	SMARCE1	Homo sapiens	Q969G3	Y2H Prey Pooling	25416956
Intra	ING5	Q8WYH8	SMARCE1	Homo sapiens	Q969G3	Y2H Array	25416956
Intra	ING5	Q8WYH8	CDCA7L	Homo sapiens	Q96GN5	Y2H Array	25416956
Intra	ING5	Q8WYH8	CDCA7L	Homo sapiens	Q96GN5	Y2H Prey Pooling	25416956
Intra	ING5	Q8WYH8	ARFIP2	Homo sapiens	P53365	Validated Y2H	25416956
Intra	ING5	Q8WYH8	ARFIP2	Homo sapiens	P53365	Y2H Prey Pooling	25416956
Intra	ING5	Q8WYH8	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	ING5	Q8WYH8	KXD1	Homo sapiens	Q9BQD3	Validated Y2H	32296183
Intra	ING5	Q8WYH8	KXD1	Homo sapiens	Q9BQD3	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	KXD1	Homo sapiens	Q9BQD3	Y2H Array	32296183
Intra	ING5	Q8WYH8	HGS	Homo sapiens	O14964	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	HGS	Homo sapiens	O14964	Y2H Array	32296183
Intra	ING5	Q8WYH8	NAV2	Homo sapiens	Q8IVL1	Y2H Prey Pooling	25416956
Intra	ING5	Q8WYH8	NAV2	Homo sapiens	Q8IVL1	Y2H Array	25416956
Intra	ING5	Q8WYH8	NAV2	Homo sapiens	Q8IVL1	Y2H Pooling	16189514
Intra	ING5	Q8WYH8	NAV2	Homo sapiens	Q8IVL1	Anti Tag CoIP	33961781
Intra	ING5	Q8WYH8	BEX3	Homo sapiens	Q00994	Y2H Array	32296183
Intra	ING5	Q8WYH8	BEX3	Homo sapiens	Q00994	Y2H Prey Pooling	32296183
Intra	ING5	Q8WYH8	CEP44	Homo sapiens	Q9C0F1	Validated Y2H	25416956
Intra	ING5	Q8WYH8	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	25416956
Intra	ING5	Q8WYH8	DEUP1	Homo sapiens	Q05D60	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ING5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75887	ING5 Protein, Human (His)	Q8WYH8-2 (E36-Q84)	≥95%

Related Diseases

Diseases

Alias

Ohdo Syndrome, Sbbys Variant

Say-Barber-Biesecker-Young-Simpson Syndrome	SBBYSS
Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Sbbys Type
Yss	Sbbys Variant Of Ohdo Syndrome
Blepharophimosis - Intellectual Disability Syndrome, Sbbys Type	Young Simpson Syndrome
Sbbyss Syndrome	Ohdo Syndrome, Say-Barber-Biesecker-Young-Simpson Variant
Blepharophimosis And Mental Retardation Syndrome, Say-Barber/Biesecker/Young-Simpson Type	Blepharophimosis-Intellectual Deficit Syndrome, Say-Barber/Biesecker/Young-Simpson Type
Bmrs Sbbys	Ohdo Syndrome, Say-Barber-Biesecker Variant
Say-Barber-Biesecker-Young-Simpson Variant Of Ohdo Syndrome	Hypothyroidism-Dysmorphism-Postaxial Polydactyly-Intellectual Disability Syndrome
Say-Barber-Biesecker Variant Of Ohdo Syndrome

Ohdo Syndrome

Young Simpson Syndrome	Ohdo Blepharophimosis Syndrome
Blepharophimosis Syndrome Ohdo Type	Blepharophimosis Intellectual Disability Syndromes
Bmrs	Blepharophimosis-Intellectual Disability Syndrome
Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth	Sbbys Syndrome
Say Barber Biesecker Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type
Bmrs, Ohdo Type	Blepharophimosis Syndrome, Ohdo Type
Ohdo-Madokoro-Sonoda Syndrome	Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type
Blepharophimosis - Intellectual Disability Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06811	ING5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ING5	RGD	RGD:1307908
Canis familiaris	ING5	VGNC	VGNC:42019
Felis catus	ING5	VGNC	VGNC:107565
Bos taurus	ING5	VGNC	VGNC:30198
Macaca mulatta	ING5	VGNC	VGNC:73627
Mus musculus	ING5	MGD	MGI:1922816
Others	ING5	NCBI

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