UBR4 - ubiquitin protein ligase E3 component n-recognin 4 Gene

Homo sapiens

Also known as p600; ZUBR1; RBAF600

Gene ID: 23352 | Gene type: protein coding

About UBR4

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,074,510-19,210,266 (from NCBI)

This gene has 17 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in testis (RPKM 21.2), bone marrow (RPKM 14.0) and 25 other tissues.

Summary

The protein encoded by this gene is an E3 ubiquitin-protein Ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound Calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

UBR4 Products(1)

mRNA	Protein	Name
NM_020765.3	NP_065816.2	E3 ubiquitin-protein ligase UBR4

UBR4 Protein Structure

zf-UBR

E3_UbLigase_R4

0
800
1600
2400
3200
4000
4800
5183 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase UBR4

N-recognin-4

Related Diseases

Diseases

Alias

Rift Valley Fever

Rfv - [Rift Valley Fever]

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Episodic Ataxia, Type 8

Episodic Ataxia Type 8	EA8
Episodic Ataxia With Slurred Speech

Episodic Ataxia, Type 4

Episodic Ataxia Type 4	Periodic Vestibulocerebellar Ataxia
Patx	EA4
Ataxia, Periodic Vestibulocerebellar

Johanson-Blizzard Syndrome

JBS	Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia, And Congenital Deafness
Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia And Congenital Deafness	Johanson Blizzard Syndrome

Episodic Ataxia, Type 3

Episodic Ataxia Type 3	EA3
Ataxia, Episodic, With Vertigo And Tinnitus	Episodic Ataxia-Vertigo-Tinnitus-Myokymia Syndrome

Episodic Ataxia, Type 7

Episodic Ataxia Type 7

EA7

Episodic Ataxia, Type 5

Episodic Ataxia Type 5	EA5
Episodic Ataxia 5	Ea-5
Ataxia, Episodic, Type 5

Severe Congenital Neutropenia 4

Autosomal Recessive Severe Congenital Neutropenia Due To G6pc3 Deficiency	Scn4
Severe Congenital Neutropenia-Pulmonary Hypertension-Superficial Venous Angiectasis Syndrome	Dursun Syndrome
Severe Congenital Neutropenia Type 4

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Episodic Ataxia

Isaacs Syndrome	Neuromyotonia
Isaacs' Syndrome	Acquired Neuromyotonia
Continuous Muscle Fiber Activity Syndrome	Quantal Squander Syndrome
Isaacs-Mertens Syndrome	Ea Syndrome
Episodic Ataxia Syndrome	Isaac Syndrome
Isaac'S-Merten'S Syndrome	Isaac-Mertens Syndrome
Peripheral Nerve Hyperexcitability	Ea
Peripheral Nerve Hyperexcitability Syndrome	Ataxia, Episodic
Isaacs Neuromyotonia	Continuous Muscle Fibre Activity

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15389	UBR4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UBR4	RGD	RGD:1563121
Mus musculus	UBR4	MGD	MGI:1916366
Felis catus	UBR4	VGNC	VGNC:66787
Macaca mulatta	UBR4	VGNC	VGNC:79845
Bos taurus	UBR4	VGNC	VGNC:36618
Canis familiaris	UBR4	VGNC	VGNC:48091

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