LARP1 - La ribonucleoprotein 1, translational regulator Gene

Homo sapiens

Also known as LARP; Lar1; Lhp1

Gene ID: 23367 | Gene type: protein coding

About LARP1

Cytogenetic location: 5q33.2 Genomic coordinates (GRCh38): 5:154,682,979-154,817,605 (from NCBI)

This gene has 20 transcripts (splice variants), 208 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 29.3), brain (RPKM 25.2) and 25 other tissues.

Summary

Enables eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and ribosomal small subunit binding activity. Involved in several processes, including TORC1 signaling; cellular response to rapamycin; and posttranscriptional regulation of gene expression. Located in cytoplasmic stress granule. Colocalizes with TORC1 complex and polysomal ribosome. [provided by Alliance of Genome Resources, Apr 2022]

LARP1 Products(9)

mRNA	Protein	Name
NM_001367713.1	NP_001354642.1	la-related protein 1 isoform 3
NM_001367714.1	NP_001354643.1	la-related protein 1 isoform 3
NM_001367715.1	NP_001354644.1	la-related protein 1 isoform 4
NM_001367716.1	NP_001354645.1	la-related protein 1 isoform 5
NM_001367717.1	NP_001354646.1	la-related protein 1 isoform 6
NM_001367718.1	NP_001354647.1	la-related protein 1 isoform 7
NM_001367719.1	NP_001354648.1	la-related protein 1 isoform 3
NM_015315.6	NP_056130.2	la-related protein 1 isoform 1
NM_033551.3	NP_291029.2	la-related protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA 7-methylguanosine cap binding	IDA IDA: Inferred from direct assay	28379136	GOA
enables RNA cap binding	IDA IDA: Inferred from direct assay	24532714	GOA
enables eukaryotic initiation factor 4E binding	IPI IPI: Inferred from physical interaction	20430826	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	23711370	GOA
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	24532714	GOA
enables mRNA 5'-UTR binding	IMP IMP: Inferred from mutant phenotype	25940091	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA
enables ribosomal small subunit binding	IDA IDA: Inferred from direct assay	28673543	GOA
enables translation activator activity	IMP IMP: Inferred from mutant phenotype	24532714	GOA
enables translation initiation factor binding	IDA IDA: Inferred from direct assay	24532714	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in TOR signaling	IMP IMP: Inferred from mutant phenotype	24532714	GOA
involved in TORC1 signaling	IMP IMP: Inferred from mutant phenotype	25940091	GOA
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	24532714	GOA
involved in cellular response to rapamycin	IMP IMP: Inferred from mutant phenotype	25940091	GOA
involved in mRNA stabilization	IMP IMP: Inferred from mutant phenotype	25940091	GOA
involved in negative regulation of translation	IMP IMP: Inferred from mutant phenotype	25940091	GOA
involved in negative regulation of translational initiation	IMP IMP: Inferred from mutant phenotype	28379136	GOA
involved in positive regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	22354037	GOA
involved in positive regulation of translational initiation	IMP IMP: Inferred from mutant phenotype	29244122	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	26735137	GOA
involved in post-transcriptional regulation of gene expression	IDA IDA: Inferred from direct assay	26001795	GOA
involved in response to amino acid starvation	IMP IMP: Inferred from mutant phenotype	25940091	GOA
involved in translational initiation	IMP IMP: Inferred from mutant phenotype	20430826	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of TORC1 complex	IDA IDA: Inferred from direct assay	24532714	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20430826	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	25940091	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LARP1 Protein Structure

0
200
400
600
800
1019 a.a.

Protein Preferred Names

Protein Names

la-related protein 1

La ribonucleoprotein domain family member 1

LARP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LARP1	Q6PKG0	YWHAZ	Homo sapiens	P63104	CoIP	15324660
Intra	LARP1	Q6PKG0	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	LARP1	Q6PKG0	YWHAE	Homo sapiens	P62258	Crosslink	36931259

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07526	LARP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07527	LARP1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LARP1	RGD	RGD:1306683
Mus musculus	LARP1	MGD	MGI:1890165
Felis catus	LARP1	VGNC	VGNC:63192
Macaca mulatta	LARP1	VGNC	VGNC:74160
Bos taurus	LARP1	VGNC	VGNC:30790
Canis familiaris	LARP1	VGNC	VGNC:42587

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