YWHAZ - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta Gene

Homo sapiens

Also known as HEL4; YWHAD; KCIP-1; HEL-S-3; POPCHAS; HEL-S-93; 14-3-3-zeta

Gene ID: 7534 | Gene type: protein coding

About YWHAZ

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:100,916,523-100,953,382 (from NCBI)

This gene has 23 transcripts (splice variants), 184 orthologues and 6 paralogues. Ubiquitous expression in esophagus (RPKM 248.0), brain (RPKM 160.0) and 25 other tissues.

Summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating Insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

YWHAZ Products(6)

mRNA	Protein	Name
NM_001135699.2	NP_001129171.1	2014/3/3 protein zeta/delta
NM_001135700.2	NP_001129172.1	2014/3/3 protein zeta/delta
NM_001135701.2	NP_001129173.1	2014/3/3 protein zeta/delta
NM_001135702.2	NP_001129174.1	2014/3/3 protein zeta/delta
NM_003406.4	NP_003397.1	2014/3/3 protein zeta/delta
NM_145690.3	NP_663723.1	2014/3/3 protein zeta/delta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16114898	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16376338	GOA
enables phosphoserine residue binding	IDA IDA: Inferred from direct assay	35662396	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7935795	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	10102273	GOA
enables protein sequestering activity	IDA IDA: Inferred from direct assay	18439900	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	18029012	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19725078	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi reassembly	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	18439900	GOA
involved in establishment of Golgi localization	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	18439900	GOA
involved in negative regulation of innate immune response	IDA IDA: Inferred from direct assay	35662396	GOA
involved in negative regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	35662396	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21621563	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	31024343	GOA
involved in regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	31024343	GOA
involved in regulation of protein stability	EXP EXP: Inferred from Experiment	21554249	GOA
involved in regulation of synapse maturation	IDA IDA: Inferred from direct assay	16959763	GOA
involved in regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	16959763	GOA
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	31024343	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	31906564	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	35662396	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16959763	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16959763	GOA
located in nucleus	IDA IDA: Inferred from direct assay	31906564	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YWHAZ Protein Structure

14-3-3

0
100
200
245 a.a.

Protein Preferred Names

Protein Names

14-3-3 protein zeta/delta

14-3-3 delta

YWHAZ Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	YWHAZ	P63104	MPRIP	Homo sapiens	Q6WCQ1	BioID	36931259
Intra	YWHAZ	P63104	MPRIP	Homo sapiens	Q6WCQ1	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	MPRIP	Homo sapiens	Q6WCQ1	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	MPRIP	Homo sapiens	Q6WCQ1	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	RAI14	Homo sapiens	Q9P0K7	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	RAI14	Homo sapiens	Q9P0K7	Anti Bait CoIP	17353931
Intra	YWHAZ	P63104	RAI14	Homo sapiens	Q9P0K7	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	RAI14	Homo sapiens	Q9P0K7	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	TGFBR1	Homo sapiens	P36897	Anti Tag CoIP	19732720
Intra	YWHAZ	P63104	MYCBP2	Homo sapiens	O75592	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	MYCBP2	Homo sapiens	O75592	Anti Tag CoIP	26496610
Intra	YWHAZ	P63104	MYCBP2	Homo sapiens	O75592	BioID	36931259
Intra	YWHAZ	P63104	YAP1	Homo sapiens	P46937	Anti Bait CoIP	25670079
Intra	YWHAZ	P63104	YAP1	Homo sapiens	P46937	Confocal	25670079
Intra	YWHAZ	P63104	YAP1	Homo sapiens	P46937	Anti Tag CoIP	25670079
Intra	YWHAZ	P63104	YAP1	Homo sapiens	P46937	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	YAP1	Homo sapiens	P46937	BioID	36931259
Intra	YWHAZ	P63104	YAP1	Homo sapiens	P46937	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	PPFIBP1	Homo sapiens	Q86W92	BioID	36931259
Intra	YWHAZ	P63104	PPFIBP1	Homo sapiens	Q86W92	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	PPFIBP1	Homo sapiens	Q86W92	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	PPP1R3D	Homo sapiens	O95685	Anti Bait CoIP	17353931
Intra	YWHAZ	P63104	DENND4A	Homo sapiens	Q7Z401	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	DENND4A	Homo sapiens	Q7Z401	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	DENND4A	Homo sapiens	Q7Z401	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	DENND4A	Homo sapiens	Q7Z401	BioID	36931259
Intra	YWHAZ	P63104	DENND4A	Homo sapiens	Q7Z401	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	SAMD4B	Homo sapiens	Q5PRF9	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	SAMD4B	Homo sapiens	Q5PRF9	Anti Bait CoIP	17353931
Intra	YWHAZ	P63104	PTPN3	Homo sapiens	P26045	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	PTPN3	Homo sapiens	P26045	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	PTPN3	Homo sapiens	P26045	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	HDAC7	Homo sapiens	Q8WUI4	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	SH3BP4	Homo sapiens	Q9P0V3	BioID	36931259
Intra	YWHAZ	P63104	SH3BP4	Homo sapiens	Q9P0V3	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	IRS2	Homo sapiens	Q9Y4H2	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	IRS2	Homo sapiens	Q9Y4H2	Anti Tag CoIP	26496610
Intra	YWHAZ	P63104	IRS2	Homo sapiens	Q9Y4H2	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	IRS2	Homo sapiens	Q9Y4H2	BioID	36931259
Intra	YWHAZ	P63104	IRS2	Homo sapiens	Q9Y4H2	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	GAPVD1	Homo sapiens	Q14C86	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	LRPPRC	Homo sapiens	P42704	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	USP8	Homo sapiens	P40818	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	USP8	Homo sapiens	P40818	Anti Bait CoIP	17353931
Intra	YWHAZ	P63104	USP8	Homo sapiens	P40818	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	USP8	Homo sapiens	P40818	BioID	36931259
Intra	YWHAZ	P63104	USP8	Homo sapiens	P40818	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	SRGAP2	Homo sapiens	O75044	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	SRGAP2	Homo sapiens	O75044	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	SRGAP2	Homo sapiens	O75044	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	SRGAP2	Homo sapiens	O75044	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	SRGAP2	Homo sapiens	O75044	BioID	36931259
Intra	YWHAZ	P63104	CDC25B	Homo sapiens	P30305	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	CDC25B	Homo sapiens	P30305	Pull Down	15629715
Intra	YWHAZ	P63104	CDC25B	Homo sapiens	P30305	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	CDC25B	Homo sapiens	P30305	CoIP	12764136
Intra	YWHAZ	P63104	CDC25B	Homo sapiens	P30305	CoIP	16672277
Intra	YWHAZ	P63104	LARP1	Homo sapiens	Q6PKG0	Anti Bait CoIP	17353931
Intra	YWHAZ	P63104	LARP1	Homo sapiens	Q6PKG0	BioID	36931259
Intra	YWHAZ	P63104	LARP1	Homo sapiens	Q6PKG0	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	LARP1	Homo sapiens	Q6PKG0	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	WWC2	Homo sapiens	Q6AWC2	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	ARHGEF16	Homo sapiens	Q5VV41	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	ARHGEF16	Homo sapiens	Q5VV41	BioID	36931259
Intra	YWHAZ	P63104	PANK2	Homo sapiens	Q9BZ23	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	CEP170	Homo sapiens	Q5SW79	BioID	36931259
Intra	YWHAZ	P63104	CEP170	Homo sapiens	Q5SW79	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	FOXO1	Homo sapiens	Q12778	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	FOXO1	Homo sapiens	Q12778	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	FOXO1	Homo sapiens	Q12778	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	FOXO1	Homo sapiens	Q12778	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	RND3	Homo sapiens	P61587	X-Ray Diffraction	23622247
Intra	YWHAZ	P63104	RND3	Homo sapiens	P61587	Pull Down	23622247
Intra	YWHAZ	P63104	RND3	Homo sapiens	P61587	SPR	23622247
Intra	YWHAZ	P63104	SIK3	Homo sapiens	Q9Y2K2	Pull Down	16306228
Intra	YWHAZ	P63104	SIK3	Homo sapiens	Q9Y2K2	BioID	36931259
Intra	YWHAZ	P63104	SIK3	Homo sapiens	Q9Y2K2	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	SIK3	Homo sapiens	Q9Y2K2	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	SIK1	Homo sapiens	P57059	Pull Down	16306228
Intra	YWHAZ	P63104	CCDC125	Homo sapiens	Q86Z20	Validated Y2H	32296183
Intra	YWHAZ	P63104	AKAP13	Homo sapiens	Q12802	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	AKAP13	Homo sapiens	Q12802	BioID	36931259
Intra	YWHAZ	P63104	AKAP13	Homo sapiens	Q12802	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	RICTOR	Homo sapiens	Q6R327	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	RICTOR	Homo sapiens	Q6R327	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	RICTOR	Homo sapiens	Q6R327	CoIP	19720745
Intra	YWHAZ	P63104	RICTOR	Homo sapiens	Q6R327	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	RICTOR	Homo sapiens	Q6R327	BioID	36931259
Intra	YWHAZ	P63104	H2AC11	Homo sapiens	P0C0S8	TAP	20618440
Intra	YWHAZ	P63104	ADAM22	Homo sapiens	Q9P0K1	CoIP	12589811
Intra	YWHAZ	P63104	ADAM22	Homo sapiens	Q9P0K1	Lex-A Dimerization	12589811
Intra	YWHAZ	P63104	ADAM22	Homo sapiens	Q9P0K1	Pull Down	12589811
Intra	YWHAZ	P63104	ADAM22	Homo sapiens	Q9P0K1	Y2H	12589811
Intra	YWHAZ	P63104	ADAM22	Homo sapiens	Q9P0K1-3	Pull Down	16868027
Intra	YWHAZ	P63104	ADAM22	Homo sapiens	Q9P0K1-3	Anti Tag CoIP	16868027
Intra	YWHAZ	P63104	ADAM22	Homo sapiens	Q9P0K1-3	Y2H	16868027
Intra	YWHAZ	P63104	ARHGAP21	Homo sapiens	Q5T5U3	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	ARHGAP21	Homo sapiens	Q5T5U3	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	ARHGAP21	Homo sapiens	Q5T5U3	BioID	36931259
Intra	YWHAZ	P63104	ARHGAP21	Homo sapiens	Q5T5U3	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	KLC3	Homo sapiens	Q6P597	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	KLC3	Homo sapiens	Q6P597	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	KIF1C	Homo sapiens	O43896	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	KIF1C	Homo sapiens	O43896	Y2H	21988832
Intra	YWHAZ	P63104	KIF1C	Homo sapiens	O43896	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	KIF1C	Homo sapiens	O43896	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	FOXO3	Homo sapiens	O43524	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	FOXO3	Homo sapiens	O43524	BioID	36931259
Intra	YWHAZ	P63104	FOXO3	Homo sapiens	O43524	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	FOXO3	Homo sapiens	O43524	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	ATL2	Homo sapiens	Q8NHH9	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	SRGAP1	Homo sapiens	Q7Z6B7	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	SRGAP1	Homo sapiens	Q7Z6B7	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	SRGAP1	Homo sapiens	Q7Z6B7	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	SIPA1L3	Homo sapiens	O60292	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	SIPA1L3	Homo sapiens	O60292	BioID	36931259
Intra	YWHAZ	P63104	SIPA1L3	Homo sapiens	O60292	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	VIRMA	Homo sapiens	Q69YN4	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	EGFR	Homo sapiens	P00533	IF	15225635
Intra	YWHAZ	P63104	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	YWHAZ	P63104	H4C16	Homo sapiens	P62805	TAP	20618440
Intra	YWHAZ	P63104	ARHGEF2	Homo sapiens	Q92974	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	ARHGEF2	Homo sapiens	Q92974	BioID	36931259
Intra	YWHAZ	P63104	ARHGEF2	Homo sapiens	Q92974	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	ARHGEF2	Homo sapiens	Q92974	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	ARHGEF2	Homo sapiens	Q92974	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	STK11	Homo sapiens	Q15831	Pull Down	22575644
Intra	YWHAZ	P63104	KIF23	Homo sapiens	Q02241	Y2H	22580824
Intra	YWHAZ	P63104	KIF23	Homo sapiens	Q02241	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	KIF23	Homo sapiens	Q02241	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	KIF23	Homo sapiens	Q02241	BioID	36931259
Intra	YWHAZ	P63104	KIF23	Homo sapiens	Q02241	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	KIF23	Homo sapiens	Q02241	Pull Down	22580824
Intra	YWHAZ	P63104	KIF23	Homo sapiens	Q02241	Anti Tag CoIP	14676191
Intra	YWHAZ	P63104	KIF23	Homo sapiens	Q02241	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	RAPGEF2	Homo sapiens	Q9Y4G8	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	MAP3K3	Homo sapiens	Q99759	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	MAP3K3	Homo sapiens	Q99759	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	MAP3K3	Homo sapiens	Q99759	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	MAP3K3	Homo sapiens	Q99759	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	HDAC4	Homo sapiens	P56524	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	HDAC4	Homo sapiens	P56524	BioID	36931259
Intra	YWHAZ	P63104	HDAC4	Homo sapiens	P56524	Pull Down	11504882
Intra	YWHAZ	P63104	HDAC4	Homo sapiens	P56524	Y2H	15964851
Intra	YWHAZ	P63104	HDAC4	Homo sapiens	P56524	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	HDAC4	Homo sapiens	P56524	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	SORBS2	Homo sapiens	O94875	BioID	36931259
Intra	YWHAZ	P63104	SORBS2	Homo sapiens	O94875	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	SORBS2	Homo sapiens	O94875	Y2H	21988832
Intra	YWHAZ	P63104	GPSM3	Homo sapiens	Q9Y4H4	Validated Y2H	32296183
Intra	YWHAZ	P63104	LMO7	Homo sapiens	Q8WWI1	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	PRMT5	Homo sapiens	O14744	Anti Tag CoIP	23455924
Intra	YWHAZ	P63104	PRMT5	Homo sapiens	O14744	Y2H	23455924
Intra	YWHAZ	P63104	RPS3	Homo sapiens	P23396	TAP	20618440
Intra	YWHAZ	P63104	ATP5F1A	Homo sapiens	P25705	TAP	20618440
Intra	YWHAZ	P63104	LIMA1	Homo sapiens	Q9UHB6	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	LMNA	Homo sapiens	P02545	TAP	20618440
Intra	YWHAZ	P63104	EEF1A1	Homo sapiens	P68104	TAP	20618440
Intra	YWHAZ	P63104	HSPB1	Homo sapiens	P04792	Reverse RRS	25277244
Intra	YWHAZ	P63104	HSPB1	Homo sapiens	P04792	TAP	20618440
Intra	YWHAZ	P63104	CFL1	Homo sapiens	P23528	Affinity Chrom	12361576
Intra	YWHAZ	P63104	VIM	Homo sapiens	P08670	TAP	20618440
Intra	YWHAZ	P63104	VIM	Homo sapiens	P08670	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	ACTB	Homo sapiens	P60709	TAP	20618440
Intra	YWHAZ	P63104	CAD	Homo sapiens	P27708	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	XPO1	Homo sapiens	O14980	Anti Tag CoIP	26496610
Intra	YWHAZ	P63104	KIF5B	Homo sapiens	P33176	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	KIF5B	Homo sapiens	P33176	BioID	36931259
Intra	YWHAZ	P63104	KIF5B	Homo sapiens	P33176	Anti Bait CoIP	17353931
Intra	YWHAZ	P63104	KIF5B	Homo sapiens	P33176	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	KIF5B	Homo sapiens	P33176	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	ESYT1	Homo sapiens	Q9BSJ8	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	DYNC1H1	Homo sapiens	Q14204	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	ATP5F1B	Homo sapiens	P06576	TAP	20618440
Intra	YWHAZ	P63104	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	YWHAE	Homo sapiens	P62258	BioID	36931259
Intra	YWHAZ	P63104	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	YWHAE	Homo sapiens	P62258	Y2H	21988832
Intra	YWHAZ	P63104	YWHAE	Homo sapiens	P62258	TAP	20618440
Intra	YWHAZ	P63104	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	26496610
Intra	YWHAZ	P63104	HNRNPC	Homo sapiens	P07910	TAP	20618440
Intra	YWHAZ	P63104	MTOR	Homo sapiens	P42345	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	MTOR	Homo sapiens	P42345	BioID	36931259
Intra	YWHAZ	P63104	ARAF	Homo sapiens	P10398	Peptide Array	19933840
Intra	YWHAZ	P63104	ARAF	Homo sapiens	P10398	Y2H Pooling	20936779
Intra	YWHAZ	P63104	ARAF	Homo sapiens	P10398	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	ARAF	Homo sapiens	P10398	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	BRAF	Homo sapiens	P15056	Anti Tag CoIP	26496610
Intra	YWHAZ	P63104	BRAF	Homo sapiens	P15056	BioID	36931259
Intra	YWHAZ	P63104	BRAF	Homo sapiens	P15056	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	BRAF	Homo sapiens	P15056	Anti Bait CoIP	17353931
Intra	YWHAZ	P63104	TP53	Homo sapiens	P04637	Anti Tag CoIP	16376338
Intra	YWHAZ	P63104	TP53	Homo sapiens	P04637	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	MAPT	Homo sapiens	P10636	CoIP	19138662
Intra	YWHAZ	P63104	MAPT	Homo sapiens	P10636	Anti Bait CoIP	17317006
Intra	YWHAZ	P63104	MAPT	Homo sapiens	P10636	Anti Tag CoIP	17317006
Intra	YWHAZ	P63104	GSK3B	Homo sapiens	P49841	Anti Tag CoIP	17317006
Intra	YWHAZ	P63104	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	ABL1	Homo sapiens	P00519	Anti Tag CoIP	15696159
Intra	YWHAZ	P63104	ABL1	Homo sapiens	P00519	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	TSC2	Homo sapiens	P49815	Pull Down	16636147
Intra	YWHAZ	P63104	TSC2	Homo sapiens	P49815	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	TSC2	Homo sapiens	P49815	TAP	20618440
Intra	YWHAZ	P63104	TSC2	Homo sapiens	P49815	Pull Down	12438239
Intra	YWHAZ	P63104	TSC2	Homo sapiens	P49815	BioID	36931259
Intra	YWHAZ	P63104	TSC2	Homo sapiens	P49815	Y2H	12468542
Intra	YWHAZ	P63104	EIF4E2	Homo sapiens	O60573	Anti Tag CoIP	35271311
Cross	YWHAZ	P63104	Bad	Mus musculus	Q61337	CoIP	12944463
Cross	YWHAZ	P63104	Bad	Mus musculus	Q61337	Biochemical	11697890
Intra	YWHAZ	P63104	WNK1	Homo sapiens	Q9H4A3	BioID	36931259
Intra	YWHAZ	P63104	WNK1	Homo sapiens	Q9H4A3	Y2H Pooling	20936779
Intra	YWHAZ	P63104	WNK1	Homo sapiens	Q9H4A3	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	PRLR	Homo sapiens	P16471	Pull Down	12819209
Intra	YWHAZ	P63104	MAP3K5	Homo sapiens	Q99683	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	MAP3K5	Homo sapiens	Q99683	Y2H	15023544
Intra	YWHAZ	P63104	MAP3K5	Homo sapiens	Q99683	CoIP	16449798
Intra	YWHAZ	P63104	SFN	Homo sapiens	P31947	TAP	20618440
Intra	YWHAZ	P63104	SFN	Homo sapiens	P31947	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	ABLIM1	Homo sapiens	O14639	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	ABLIM1	Homo sapiens	O14639	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	ABLIM1	Homo sapiens	O14639	BioID	36931259
Intra	YWHAZ	P63104	ABLIM1	Homo sapiens	O14639	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	14676191
Intra	YWHAZ	P63104	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	MARK2	Homo sapiens	Q7KZI7	Pull Down	15324659
Intra	YWHAZ	P63104	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	MARK2	Homo sapiens	Q7KZI7	Far-WB	15161933
Intra	YWHAZ	P63104	CBL	Homo sapiens	P22681	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	CBL	Homo sapiens	P22681	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	CBL	Homo sapiens	P22681	TAP	20618440
Intra	YWHAZ	P63104	TBC1D4	Homo sapiens	O60343	BioID	36931259
Intra	YWHAZ	P63104	TBC1D4	Homo sapiens	O60343	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	TBC1D4	Homo sapiens	O60343	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	TBC1D4	Homo sapiens	O60343	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	BAIAP2	Homo sapiens	Q9UQB8	Peptide Array	19933840
Intra	YWHAZ	P63104	BAIAP2	Homo sapiens	Q9UQB8	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	BAIAP2	Homo sapiens	Q9UQB8	BioID	36931259
Intra	YWHAZ	P63104	BAIAP2	Homo sapiens	Q9UQB8	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	BAIAP2	Homo sapiens	Q9UQB8	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	DISC1	Homo sapiens	Q9NRI5	Y2H	17043677
Intra	YWHAZ	P63104	LRRK2	Homo sapiens	Q5S007	SPR	24351927
Intra	YWHAZ	P63104	LRRK2	Homo sapiens	Q5S007	FPS	24351927
Intra	YWHAZ	P63104	LRRK2	Homo sapiens	Q5S007	Protein Array	24947832
Intra	YWHAZ	P63104	CPS1	Homo sapiens	P31327	TAP	20618440
Intra	YWHAZ	P63104	MAP3K20	Homo sapiens	Q9NYL2	Pull Down	21988832
Intra	YWHAZ	P63104	MAP3K20	Homo sapiens	Q9NYL2	Anti Tag CoIP	21988832
Intra	YWHAZ	P63104	MAP3K20	Homo sapiens	Q9NYL2	Confocal	21988832
Intra	YWHAZ	P63104	MAP3K20	Homo sapiens	Q9NYL2	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	MAP3K20	Homo sapiens	Q9NYL2	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	MAP3K20	Homo sapiens	Q9NYL2	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	MAP3K20	Homo sapiens	Q9NYL2	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	MAP3K20	Homo sapiens	Q9NYL2	Y2H	21988832
Intra	YWHAZ	P63104	STK25	Homo sapiens	O00506	Protein Kinase Assay	15037601
Intra	YWHAZ	P63104	CDK17	Homo sapiens	Q00537	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	CDK17	Homo sapiens	Q00537	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	CDK17	Homo sapiens	Q00537	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	PIK3C2B	Homo sapiens	O00750	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	PIK3C2B	Homo sapiens	O00750	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	PIK3C2B	Homo sapiens	O00750	BioID	36931259
Intra	YWHAZ	P63104	PIK3C2B	Homo sapiens	O00750	Anti Tag CoIP	35271311
Cross	YWHAZ	P63104	Rnd3	Mus musculus	P61588	Anti Tag CoIP	23622247
Intra	YWHAZ	P63104	BAD	Homo sapiens	Q92934	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	BAD	Homo sapiens	Q92934	CoIP	11526496
Intra	YWHAZ	P63104	BAD	Homo sapiens	Q92934	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	BAD	Homo sapiens	Q92934	Confocal	21988832
Intra	YWHAZ	P63104	BAD	Homo sapiens	Q92934	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	PACS2	Homo sapiens	Q86VP3	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	PACS2	Homo sapiens	Q86VP3	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	PACS2	Homo sapiens	Q86VP3	CoIP	19481529
Intra	YWHAZ	P63104	PRKCE	Homo sapiens	Q02156	X-Ray Diffraction	19662078
Intra	YWHAZ	P63104	REPS2	Homo sapiens	Q8NFH8	Anti Tag CoIP	18647389
Intra	YWHAZ	P63104	REPS2	Homo sapiens	Q8NFH8	Pull Down	18647389
Intra	YWHAZ	P63104	MARK3	Homo sapiens	P27448	Pull Down	16306228
Intra	YWHAZ	P63104	MARK3	Homo sapiens	P27448	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	MARK3	Homo sapiens	P27448	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	MARK3	Homo sapiens	P27448	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	MARK3	Homo sapiens	P27448	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	MARK3	Homo sapiens	P27448	Anti Tag CoIP	14676191
Intra	YWHAZ	P63104	MARK3	Homo sapiens	P27448	Anti Tag CoIP	16959763
Intra	YWHAZ	P63104	MARK3	Homo sapiens	P27448	BioID	36931259
Intra	YWHAZ	P63104	PAK4	Homo sapiens	O96013	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	PAK4	Homo sapiens	O96013	BioID	36931259
Intra	YWHAZ	P63104	PAK4	Homo sapiens	O96013	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	PAK4	Homo sapiens	O96013	Anti Bait CoIP	17353931
Intra	YWHAZ	P63104	MAPT	Homo sapiens	P10636-3	Comig Non-Denat Gel	19647741
Intra	YWHAZ	P63104	MAPT	Homo sapiens	P10636-3	Crosslink	19647741
Intra	YWHAZ	P63104	MAPT	Homo sapiens	P10636-3	GMS	19647741
Intra	YWHAZ	P63104	HDAC5	Homo sapiens	Q9UQL6	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	HDAC5	Homo sapiens	Q9UQL6	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	HDAC5	Homo sapiens	Q9UQL6	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	DNMT1	Homo sapiens	P26358	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	HECTD4	Homo sapiens	Q9Y4D8	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	AKT1S1	Homo sapiens	Q96B36	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	CDK16	Homo sapiens	Q00536	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	KLC2	Homo sapiens	Q9H0B6	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	KLC2	Homo sapiens	Q9H0B6	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	KLC2	Homo sapiens	Q9H0B6	BioID	36931259
Intra	YWHAZ	P63104	KLC2	Homo sapiens	Q9H0B6	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	KLC2	Homo sapiens	Q9H0B6	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	APC	Homo sapiens	P25054	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	YWHAZ	P63104	PCM1	Homo sapiens	Q15154	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	NADK	Homo sapiens	O95544	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	NADK	Homo sapiens	O95544	Anti Bait CoIP	17353931
Intra	YWHAZ	P63104	CDK18	Homo sapiens	Q07002	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	CDK18	Homo sapiens	Q07002	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	SH3BP5L	Homo sapiens	Q7L8J4	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	CDC25A	Homo sapiens	P30304	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	WTAP	Homo sapiens	Q15007	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	FAM53B	Homo sapiens	Q14153	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	FAM53B	Homo sapiens	Q14153	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	PFKFB2	Homo sapiens	O60825	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	PFKFB2	Homo sapiens	O60825	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	PFKFB2	Homo sapiens	O60825	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	PFKFB2	Homo sapiens	O60825	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	GIGYF2	Homo sapiens	Q6Y7W6	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	TP53BP2	Homo sapiens	Q13625	BioID	36931259
Intra	YWHAZ	P63104	TP53BP2	Homo sapiens	Q13625	Anti Tag CoIP	26496610
Intra	YWHAZ	P63104	TP53BP2	Homo sapiens	Q13625	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	TP53BP2	Homo sapiens	Q13625	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	NPM1	Homo sapiens	P06748	TAP	20618440
Intra	YWHAZ	P63104	CGN	Homo sapiens	Q9P2M7	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	CGN	Homo sapiens	Q9P2M7	BioID	36931259
Intra	YWHAZ	P63104	CGN	Homo sapiens	Q9P2M7	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	PARD3	Homo sapiens	Q8TEW0	BioID	36931259
Intra	YWHAZ	P63104	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	14676191
Intra	YWHAZ	P63104	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	33961781
Intra	YWHAZ	P63104	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	ENTREP1	Homo sapiens	Q15884	Y2H	34927784
Intra	YWHAZ	P63104	WEE1	Homo sapiens	P30291	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	WEE1	Homo sapiens	P30291	Anti Tag CoIP	36931259
Intra	YWHAZ	P63104	WEE1	Homo sapiens	P30291	Far-WB	15161933
Intra	YWHAZ	P63104	ATXN1	Homo sapiens	P54253	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	ATXN1	Homo sapiens	P54253	Imaging	12757707
Intra	YWHAZ	P63104	CBY1	Homo sapiens	Q9Y3M2	CoIP	19940019
Intra	YWHAZ	P63104	CBY1	Homo sapiens	Q9Y3M2	Anti Tag CoIP	28514442
Intra	YWHAZ	P63104	GCH1	Homo sapiens	P30793	Confocal	21988832
Intra	YWHAZ	P63104	CDC25C	Homo sapiens	P30307	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	35271311
Intra	YWHAZ	P63104	EDC3	Homo sapiens	Q96F86	Anti Bait CoIP	17353931
Intra	YWHAZ	P63104	EDC3	Homo sapiens	Q96F86	BioID	36931259
Cross	YWHAZ	P63104	AANAT	Ovis aries	Q29495	Cosedimentation	11336675
Cross	YWHAZ	P63104	AANAT	Ovis aries	Q29495	X-Ray Diffraction	11336675
Cross	YWHAZ	P63104	MAPT	Bos taurus	P29172	Pull Down	10840038
Cross	YWHAZ	P63104	CSNK1A1	Oryctolagus cuniculus	P67828	Pull Down	19860830
Cross	YWHAZ	P63104	Hap1	Rattus norvegicus	P54256-2	Anti Bait CoIP	17166838
Cross	YWHAZ	P63104	Hap1	Rattus norvegicus	P54256-2	IF	17166838
Cross	YWHAZ	P63104	Hap1	Rattus norvegicus	P54256-2	Fluorescence Spectr	17166838
Cross	YWHAZ	P63104	Hap1	Rattus norvegicus	P54256-2	Pull Down	17166838

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15945	YWHAZ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	YWHAZ	VGNC	VGNC:53885
Macaca mulatta	YWHAZ	VGNC	VGNC:84137
Mus musculus	YWHAZ	MGD	MGI:109484
Rattus norvegicus	YWHAZ	RGD	RGD:3980
Others	YWHAZ	NCBI

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