CTDNEP1 - CTD nuclear envelope phosphatase 1 Gene

Homo sapiens

Also known as NET56; DULLARD; HSA011916

Gene ID: 23399 | Gene type: protein coding

About CTDNEP1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,243,591-7,251,978 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 230 orthologues and 5 paralogues. Ubiquitous expression in spleen (RPKM 30.6), appendix (RPKM 29.9) and 25 other tissues.

Summary

Enables protein serine/threonine Phosphatase activity. Involved in several processes, including positive regulation of triglyceride biosynthetic process; protein dephosphorylation; and protein localization to nucleus. Located in endoplasmic reticulum membrane; lipid droplet; and nuclear membrane. Part of Nem1-Spo7 Phosphatase complex. [provided by Alliance of Genome Resources, Apr 2022]

CTDNEP1 Products(2)

mRNA	Protein	Name
NM_001143775.2	NP_001137247.1	CTD nuclear envelope phosphatase 1
NM_015343.5	NP_056158.2	CTD nuclear envelope phosphatase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22134922	GOA
enables protein serine/threonine phosphatase activity	IMP IMP: Inferred from mutant phenotype	17420445	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nuclear envelope organization	IDA IDA: Inferred from direct assay	17420445	GOA
involved in positive regulation of triglyceride biosynthetic process	IGI IGI: Inferred from genetic interaction	22134922	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	17420445	GOA
involved in protein localization to nucleus	IDA IDA: Inferred from direct assay	22134922	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Nem1-Spo7 phosphatase complex	IDA IDA: Inferred from direct assay	22134922	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22134922	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	17420445	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	17420445	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	22134922	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTDNEP1 Protein Structure

NIF

0
100
200
244 a.a.

Protein Preferred Names

Protein Names

CTD nuclear envelope phosphatase 1

C-terminal domain nuclear envelope phosphatase 1

CTDNEP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CTDNEP1	O95476	CNEP1R1	Homo sapiens	Q8N9A8	IF	22134922
Intra	CTDNEP1	O95476	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	CTDNEP1	O95476	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	CTDNEP1	O95476	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03289	CTDNEP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CTDNEP1	VGNC	VGNC:71440
Bos taurus	CTDNEP1	VGNC	VGNC:27789
Canis familiaris	CTDNEP1	VGNC	VGNC:39691
Felis catus	CTDNEP1	VGNC	VGNC:61245
Rattus norvegicus	CTDNEP1	RGD	RGD:1310172
Mus musculus	CTDNEP1	MGD	MGI:1914431

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