2. Gene
  3. SIRT5 - sirtuin 5 Gene

SIRT5 - sirtuin 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SIR2L5

Gene ID: 23408 | Gene type: protein coding

About SIRT5

Cytogenetic location: 6p23 Genomic coordinates (GRCh38): 6:13,574,274-13,615,158 (from NCBI)

This gene has 24 transcripts (splice variants), 265 orthologues and 6 paralogues. Ubiquitous expression in heart (RPKM 3.7), liver (RPKM 2.6) and 25 other tissues.

Summary

This gene encodes a member of the Sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast Sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the Sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]

SIRT5 Products(43)

mRNA Protein Name
NM_001376798.1 NP_001363727.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
XM_047418518.1 XP_047274474.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2
NM_001376815.1 NP_001363744.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 8
XM_047418524.1 XP_047274480.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3
XM_047418514.1 XP_047274470.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1
XM_047418515.1 XP_047274471.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1
NM_001376814.1 NP_001363743.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 7
XM_047418522.1 XP_047274478.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3
XM_047418519.1 XP_047274475.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2
NR_164856.1
NM_001376802.1 NP_001363731.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NM_001376808.1 NP_001363737.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 2
NM_001376806.1 NP_001363735.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
XM_017010620.3 XP_016866109.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3
NM_001376803.1 NP_001363732.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NM_001376804.1 NP_001363733.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NM_001376812.1 NP_001363741.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 4
NM_001376813.1 NP_001363742.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 7
NM_001376811.1 NP_001363740.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 6
NM_001376805.1 NP_001363734.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NR_164852.1
NM_001242827.1 NP_001229756.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 4
NR_164853.1
XM_017010624.3 XP_016866113.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X5
NM_001376810.1 NP_001363739.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 5
NM_001193267.2 NP_001180196.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 3
NM_012241.5 NP_036373.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
XM_047418521.1 XP_047274477.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3
XM_047418526.1 XP_047274482.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4
XM_047418525.1 XP_047274481.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4
XM_047418527.1 XP_047274483.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4
XM_024446388.2 XP_024302156.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X6
XM_047418523.1 XP_047274479.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3
NM_001376800.1 NP_001363729.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NM_001376799.1 NP_001363728.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NM_001376809.1 NP_001363738.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 5
NM_001376801.1 NP_001363730.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
NM_001376807.1 NP_001363736.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
XM_047418517.1 XP_047274473.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2
XM_047418520.1 XP_047274476.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2
XM_047418516.1 XP_047274472.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1
NR_164854.1
NM_031244.3 NP_112534.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NAD+ binding IDA
IDA: Inferred from direct assay
21908771 GOA
enables protein-glutaryllysine deglutarylase activity IDA
IDA: Inferred from direct assay
24703693 GOA
enables protein-malonyllysine demalonylase activity IDA
IDA: Inferred from direct assay
21908771 GOA
enables protein-succinyllysine desuccinylase activity IDA
IDA: Inferred from direct assay
21908771 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
22076378 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
24140062 GOA
involved in peptidyl-lysine demalonylation IDA
IDA: Inferred from direct assay
21908771 GOA
involved in peptidyl-lysine desuccinylation IDA
IDA: Inferred from direct assay
21908771 GOA
NOT involved in protein deacetylation IDA
IDA: Inferred from direct assay
22076378 GOA
involved in protein deacetylation IDA
IDA: Inferred from direct assay
18680753 GOA
involved in protein deglutarylation IDA
IDA: Inferred from direct assay
24703693 GOA
involved in protein demalonylation IDA
IDA: Inferred from direct assay
24703693 GOA
involved in protein desuccinylation IDA
IDA: Inferred from direct assay
24140062 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
23806337 GOA
located in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
18680753 GOA
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
18680753 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
16079181 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRT5 Protein Structure

SIR2

SIR2: Sir2 family (58 - 256)

  • 0
  • 100
  • 200
  • 310 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacylase sirtuin-5, mitochondrial

NAD-dependent deacetylase sirtuin-5

NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial

silent mating type information regulation 2, S.cerevisiae, homolog 5

sir2-like 5

sirtuin type 5

Recombinant SIRT5 Proteins

Cat. No. Product Name Accession Purity
HY-P74545 SIRT5 Protein, Human (Flag) NP_036373.1/Q9NXA8-1 (R2-S310) ≥95%

Related Diseases

Diseases Alias
Monckeberg Arteriosclerosis

Monckeberg Medial Calcific Sclerosis
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency

Nadh:Q(1) Oxidoreductase Deficiency

MC1DN1

Nadh-Coenzyme Q Reductase Deficiency

Isolated Mitochondrial Respiratory Chain Complex I Deficiency

Isolated Nadh-Coenzyme Q Reductase Deficiency

Isolated Nadh-Coq Reductase Deficiency

Isolated Nadh-Ubiquinone Reductase Deficiency

Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

Nuclear Type Mitochondrial Complex I Deficiency 1

Isolated Complex I Deficiency

Complex 1 Mitochondrial Respiratory Chain Deficiency

Nadh Coenzyme Q Reductase Deficiency

Complex I Mitochondrial Respiratory Chain Deficiency

Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

Nadh:Ubiquinone Oxidoreductase Deficiency

Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Non-Alcoholic Fatty Liver Disease

Fatty Liver

Non-Alcoholic Fatty Liver

Nafld

Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis

Steatosis

Nafl

Nash

Non-Alcoholic Steatohepatitis

Susceptibility To Nonalcoholic Fatty Liver Disease

Steatohepatitis

Fatty Degeneration

Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

Nafld Without Nash

Nafld Without Mention Of Nash
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0879A Suramin sodium salt Inhibitor 99.48% Yes
HY-B0879 Suramin Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-146387 SIRT5 inhibitor 3 Inhibitor ≥98.0% Unkown
HY-145651 Et-29 Inhibitor 99.89% Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor / Unkown
HY-152214 SIRT5 inhibitor 5 Inhibitor / Unkown
HY-146386 SIRT5 inhibitor 2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SIRT5 VGNC VGNC:46186
Rattus norvegicus SIRT5 RGD RGD:1303285
Macaca mulatta SIRT5 VGNC VGNC:77485
Mus musculus SIRT5 MGD MGI:1915596
Felis catus SIRT5 VGNC VGNC:65159
Bos taurus SIRT5 VGNC VGNC:34634
Others SIRT5 NCBI