1. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage Anti-infection Apoptosis
  2. Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis
  3. Suramin

Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM). Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM). Suramin is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor.Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Suramin sodium salt) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Suramin Chemical Structure

Suramin Chemical Structure

CAS No. : 145-63-1

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Top Publications Citing Use of Products

    Suramin purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2020 Jul 24;295(30):10281-10292.  [Abstract]

    Suramin inhibits IP5K function in vivo. Immunoprecipitation of myc-CSN2 from myc-CSN2-HEK293 stable cell after IP5K knockdown, with or without Suramin or NF449 treatment.

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    Description

    Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor[1]. Suramin is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM)[2]. Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM)[3][4]. Suramin is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor[5].Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent[6][7][8].

    IC50 & Target[2]

    SIRT1

    297 nM (IC50)

    SIRT2

    1.15 μM (IC50)

    SIRT5

    22 μM (IC50)

    Cellular Effect
    Cell Line Type Value Description References
    HUVEC IC50
    500 μM
    Compound: Sur
    Antiproliferative activity against human HUVEC after 48 to 72 hrs by MTT assay
    Antiproliferative activity against human HUVEC after 48 to 72 hrs by MTT assay
    [PMID: 22182929]
    HUVEC IC50
    500 μM
    Compound: Suramin
    Antiproliferative activity against human umbilical vein endothelial cells (HUVECs) using MTT assay
    Antiproliferative activity against human umbilical vein endothelial cells (HUVECs) using MTT assay
    [PMID: 11591505]
    L6 IC50
    4725 μM
    Compound: Sr
    Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
    Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
    [PMID: 25746816]
    MRC5 IC50
    > 100 μg/mL
    Compound: suramin
    Cytotoxicity against human MRC5 cells after 7 days by MTT assay
    Cytotoxicity against human MRC5 cells after 7 days by MTT assay
    [PMID: 19013823]
    MRC5 IC50
    > 64 μM
    Compound: Suramin
    Cytotoxicity against human MRC5 SV2 cells assessed as reduction in cell growth after 72 hrs
    Cytotoxicity against human MRC5 SV2 cells assessed as reduction in cell growth after 72 hrs
    [PMID: 25199582]
    MT4 CC50
    47 μM
    Compound: Suramin
    Cytotoxicity against HIV-1 in MT-4 cells was evaluated by using a clinical strain (HE)
    Cytotoxicity against HIV-1 in MT-4 cells was evaluated by using a clinical strain (HE)
    [PMID: 8336338]
    MT4 EC50
    8 μM
    Compound: Suramin
    Antiviral activity against HIV-1 in MT-4 cells was evaluated by using a clinical strain (HE)
    Antiviral activity against HIV-1 in MT-4 cells was evaluated by using a clinical strain (HE)
    [PMID: 8336338]
    In Vitro

    Suramin (50-600 μg/mL; for 24-96 hours) inhibits cells proliferation in a dose-dependent and time-dependent manner and decreases viability in cancer cells[7].
    Suramin (300 μg/mL; for 48 hours) induces cells apoptosis, and down-regulates mRNA expression in HeLa cells[7].
    Suramin (1 mg/mL; 1 hour) significantly suppresses the phosphorylated ERK1/2[8].
    The IC50 values of HO-8910 PM and HeLa are 319 μg/mL, 476 μg/mL, respectively[7].
    Suramin blocks viral replication in Vero E6 cells[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[6]

    Cell Line: HO-8910 PM ovarian and Hela cervical cancer cells
    Concentration: 50, 100, 200, 300, 400, 500 and 600 μg/mL
    Incubation Time: For 24, 48, 72 and 96 hours
    Result: Inhibited cells proliferation in a dose-dependent and time-dependent manner.

    Apoptosis Analysis[6]

    Cell Line: HeLa cells
    Concentration: 300 μg/mL
    Incubation Time: For 48 hours
    Result: Induced cells apoptosis.

    Western Blot Analysis[7]

    Cell Line: PA-SMCs cells
    Concentration: 1 mg/mL
    Incubation Time: For 1 hours
    Result: Significantly suppressed the phosphorylated ERK1/2.
    In Vivo

    Suramin (10 mg/kg; IV; twice weekly for 3 weeks) reverses established pulmonary hypertension (PH), thereby normalizing the pulmonary artery pressure values and vessel structure[8].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Adult male Wistar rats (200-225 g)[7]
    Dosage: 10 mg/kg
    Administration: IV; twice weekly for 3 weeks
    Result: Reversed established PH, thereby normalizing the pulmonary artery pressure values and vessel structure.
    Clinical Trial
    Molecular Weight

    1297.28

    Formula

    C51H40N6O23S6

    CAS No.
    SMILES

    O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O)=O)C4=CC(S(=O)(O)=O)=CC(S(=O)(O)=O)=C34)=O)=CC=C2C)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O)=O)C8=CC(S(=O)(O)=O)=CC(S(=O)(O)=O)=C78)=O)=CC=C6C)=O)=CC=C5

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Suramin
    Cat. No.:
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