SIRT4 - sirtuin 4 Gene

Homo sapiens

Also known as SIR2L4

Gene ID: 23409 | Gene type: protein coding

About SIRT4

Cytogenetic location: 12q24.23-q24.31 Genomic coordinates (GRCh38): 12:120,291,780-120,313,249 (from NCBI)

This gene has 3 transcripts (splice variants), 193 orthologues and 6 paralogues. Broad expression in testis (RPKM 2.4), kidney (RPKM 1.1) and 24 other tissues.

Summary

This gene encodes a member of the Sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast Sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the Sirtuin family. [provided by RefSeq, Jul 2008]

SIRT4 Products(4)

mRNA	Protein	Name
NM_001385733.1	NP_001372662.1	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform 1
NM_001385734.1	NP_001372663.1	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform 2
NM_001385735.1	NP_001372664.1	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform 2
NM_012240.3	NP_036372.1	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	16959573	GOA
enables NAD-dependent protein biotinidase activity	IDA IDA: Inferred from direct assay	25525879	GOA
enables NAD-dependent protein lipoamidase activity	IDA IDA: Inferred from direct assay	25525879	GOA
NOT enables NAD-dependent protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	17715127	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16959573	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	24043310	GOA
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	17715127	GOA
involved in regulation of pyruvate dehydrogenase activity	IDA IDA: Inferred from direct assay	25525879	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	16959573	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	16079181	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRT4 Protein Structure

SIR2

0
100
200
314 a.a.

Protein Preferred Names

Protein Names

NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

NAD-dependent ADP-ribosyltransferase sirtuin-4

SIRT4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SIRT4	Q9Y6E7	DLAT	Homo sapiens	P10515	Lipid Cleavage	25525879
Intra	SIRT4	Q9Y6E7	DLAT	Homo sapiens	P10515	Anti Tag CoIP	25525879
Intra	SIRT4	Q9Y6E7	SLC25A5	Homo sapiens	P05141	Anti Tag CoIP	17715127
Intra	SIRT4	Q9Y6E7	PDHX	Homo sapiens	O00330	Confocal	25525879
Intra	SIRT4	Q9Y6E7	PDHX	Homo sapiens	O00330	Lipid Cleavage	25525879
Intra	SIRT4	Q9Y6E7	PDHX	Homo sapiens	O00330	Anti Tag CoIP	25525879

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hyperinsulinism

Hyperinsulinemia

Monckeberg Arteriosclerosis

Monckeberg Medial Calcific Sclerosis

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163316	SIRT4-IN-1	Inhibitor	97.52%	Unkown
HY-RS12946	SIRT4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIRT4	MGD	MGI:1922637
Rattus norvegicus	SIRT4	RGD	RGD:1310413
Canis familiaris	SIRT4	VGNC	VGNC:46185
Macaca mulatta	SIRT4	VGNC	VGNC:100105
Felis catus	SIRT4	VGNC	VGNC:65158
Bos taurus	SIRT4	VGNC	VGNC:34633
Others	SIRT4	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.