2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. SIRT4-IN-1

SIRT4-IN-1 (compound 69) is selective sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 μM.SIRT4-IN-1 shows no relevant effects on other sirtuin isoforms.

For research use only. We do not sell to patients.

SIRT4-IN-1 Chemical Structure

SIRT4-IN-1 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 277 In-stock
Solution
10 mM * 1 mL in DMSO USD 277 In-stock
Solid
5 mg USD 250 In-stock
10 mg USD 410 In-stock
25 mg USD 830 In-stock
50 mg USD 1340 In-stock
100 mg USD 2150 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

SIRT4-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All Sirtuin Isoform Specific Products:

View All Isoforms
Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SIRT4-IN-1 (compound 69) is selective sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 μM.SIRT4-IN-1 shows no relevant effects on other sirtuin isoforms[1].

Molecular Weight

503.53

Formula

C19H13N5O6S3
Appearance

Solid

Color

Yellow to brown

SMILES

O=C1C2=C(N=C(N1)SCC(NC3=NC=C(S3)S(C4=CC=C(C=C4)[N+]([O-])=O)(=O)=O)=O)C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (198.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9860 mL 9.9299 mL 19.8598 mL
5 mM 0.3972 mL 1.9860 mL 3.9720 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9860 mL 9.9299 mL 19.8598 mL 49.6495 mL
5 mM 0.3972 mL 1.9860 mL 3.9720 mL 9.9299 mL
10 mM 0.1986 mL 0.9930 mL 1.9860 mL 4.9649 mL
15 mM 0.1324 mL 0.6620 mL 1.3240 mL 3.3100 mL
20 mM 0.0993 mL 0.4965 mL 0.9930 mL 2.4825 mL
25 mM 0.0794 mL 0.3972 mL 0.7944 mL 1.9860 mL
30 mM 0.0662 mL 0.3310 mL 0.6620 mL 1.6550 mL
40 mM 0.0496 mL 0.2482 mL 0.4965 mL 1.2412 mL
50 mM 0.0397 mL 0.1986 mL 0.3972 mL 0.9930 mL
60 mM 0.0331 mL 0.1655 mL 0.3310 mL 0.8275 mL
80 mM 0.0248 mL 0.1241 mL 0.2482 mL 0.6206 mL
100 mM 0.0199 mL 0.0993 mL 0.1986 mL 0.4965 mL
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SIRT4-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIRT4-IN-1SirtuinSIRT4 InhibitorMitochondrial DeacylaseInhibitorinhibitorinhibit

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