FOLH1 - folate hydrolase 1 Gene

Homo sapiens

Also known as PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1

Gene ID: 2346 | Gene type: protein coding

About FOLH1

Cytogenetic location: 11p11.12 Genomic coordinates (GRCh38): 11:49,145,092-49,208,602 (from NCBI)

This gene has 13 transcripts (splice variants), 212 orthologues and 5 paralogues. Biased expression in duodenum (RPKM 94.9), prostate (RPKM 43.3) and 6 other tissues.

Summary

This gene encodes a type II Transmembrane Glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate Carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate Cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

FOLH1 Products(6)

mRNA	Protein	Name
NM_001014986.3	NP_001014986.1	glutamate carboxypeptidase 2 isoform 2
NM_001193471.3	NP_001180400.1	glutamate carboxypeptidase 2 isoform 3
NM_001193472.3	NP_001180401.1	glutamate carboxypeptidase 2 isoform 4
NM_001193473.3	NP_001180402.1	glutamate carboxypeptidase 2 isoform 5
NM_001351236.2	NP_001338165.1	glutamate carboxypeptidase 2 isoform 6
NM_004476.3	NP_004467.1	glutamate carboxypeptidase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Ac-Asp-Glu binding	IDA IDA: Inferred from direct assay	24863754	GOA
enables metallocarboxypeptidase activity	IDA IDA: Inferred from direct assay	12949938	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables tetrahydrofolyl-poly(glutamate) polymer binding	IDA IDA: Inferred from direct assay	24863754	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in C-terminal protein deglutamylation	IDA IDA: Inferred from direct assay	12949938	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	12949938	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	12949938	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12949938	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOLH1 Protein Structure

Peptidase_M28

TFR_dimer

0
200
400
600
750 a.a.

Protein Preferred Names

Protein Names

glutamate carboxypeptidase 2

N-acetylated alpha-linked acidic dipeptidase 1

Recombinant FOLH1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70548	PSMA Protein, Human (HEK293, His, solution)	Q04609-1 (K44-A750)	≥95%
HY-P76703	PSMA Protein, Human (Biotinylated, HEK293, His)	Q04609-1/NP_004467.1 (K44-A750)	≥95%

Related Diseases

Diseases

Alias

Hyperhomocysteinemia

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Lymph Node Carcinoma

Lymph Node Cancer	Lymph Node Neoplasm
Neoplasm Of Lymph Node

Prostate Disease

Prostatic Diseases

Prostate Diseases

Canavan Disease

Aspartoacylase Deficiency	Aminoacylase 2 Deficiency
Spongy Degeneration Of Central Nervous System	Aspa Deficiency
Acy2 Deficiency	Canavan-Van Bogaert-Bertrand Disease
Mild Canavan Disease	Asp Deficiency
Spongy Degeneration Of The Central Nervous System	Severe Canavan Disease
Von Bogaert-Bertrand Disease	Canavan'S Disease
Spongy Degeneration Of The Brain	Juvenile Canavan Disease
Infantile Canavan Disease	Neonatal Canavan Disease
CAND	Disease, Canavan
Canavan Disease, Juvenile	Canavan Disease, Infantile
Canavan Disease, Neonatal

Anthracosilicosis

Castration-Resistant Prostate Carcinoma

Prostatic Neoplasms, Castration-Resistant

Bladder Lateral Wall Cancer

Lateral Wall Of Bladder

Malignant Neoplasm Of Lateral Wall Of Urinary Bladder

Prostatic Hyperplasia, Benign

Benign Prostatic Hyperplasia	BPH
Prostatic Hyperplasia

Maxillary Sinus Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Maxillary Sinus

Adenoid Cystic Carcinoma Of The Maxillary Sinus

Prostatic Acinar Adenocarcinoma

Acinar Prostate Adenocarcinoma

Urethral Stricture

Ankylurethria	Urethral Stenosis
Urethral Contracture	Urethral Obstruction
Meatal Stenosis Nos	Constriction Of Urethra
Contraction Of Urethra	Stricture Of Urinary Meatus
Urethral Obliteration	Urethral Narrowing
Pinpoint Meatus	Pinhole Meatus Nos
Urethral Occlusion

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Paraurethral Gland Cancer

Malignant Tumor Of Paraurethral Gland	Malignant Tumor Of The Paraurethral Gland
Skene Gland Carcinoma	Carcinoma Of The Paraurethral Gland
Paraurethral Gland Carcinoma

Lymphocele

Lymph Cyst

Lymphocele Adverse Event

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Prostate Small Cell Carcinoma

Small Cell Carcinoma Of Prostate

Prostate Oat Cell Carcinoma

Mucocele Of Salivary Gland

Ranula	Salivary Cyst
Salivary Gland Mucocele	Mucous Retention Cyst Of Salivary Gland
Retention Cyst Of Salivary Gland	Sialocele
Cyst Of Salivary Gland Or Duct	Extravasation Cyst Of Salivary Gland

Prostatic Hypertrophy

Benign Prostatic Hypertrophy

Prostatic Hyperplasia

Nodular Prostate

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma	Adenocarcinoma Of Prostate
ST12	Prostate Adenocarcinoma 1
Pac1

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Primary Cutaneous Amyloidosis

Plca	Primary Localized Cutaneous Amyloidosis
Familial Primary Localized Cutaneous Amyloidosis	Amyloidosis Ix
Lichen Amyloidosis Familial	Amyloidosis, Primary Cutaneous
Pca	Amyloidosis 9
Amyloidosis Familial Cutaneous Lichen	Fplca
Familial Lichen Amyloidosis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Kidney Cancer

Renal Cancer	Renal Carcinoma
Kidney Neoplasm	Malignant Neoplasm Of Kidney Except Pelvis
Malignant Tumour Of Kidney	Kidney Neoplasms
Cancer, Kidney	Cancer, Renal
Malignant Neoplasm Of Kidney	Renal Cell Carcinoma

Male Reproductive Organ Cancer

Genital Neoplasms, Male	Male Genital Cancer
Male Genital Neoplasm	Male Reproductive System Neoplasm
Malignant Neoplasm Of Male Genital Organ	Malignant Neoplasm Of Male Genital Organ Or Tract
Malignant Neoplasm Of Male Genital Organs	Malignant Tumor Of Male Genital Organ
Malignant Tumor Of Male Reproductive System	Neoplasm Of Male Genital Organ
Tumor Of Male Reproductive System

Male Reproductive System Disease

Genital Diseases, Male

Disorder Of Male Reproductive System

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Prostate Neuroendocrine Neoplasm

Neuroendocrine Tumor Of The Prostate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05028	FOLH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990752	Nezastomig		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FOLH1	MGD	MGI:1858193
Rattus norvegicus	FOLH1	RGD	RGD:70963
Macaca fascicularis	FOLH1	NCBI
Others	FOLH1	NCBI