CABIN1 - calcineurin binding protein 1 Gene

Homo sapiens

Also known as CAIN; PPP3IN; KB-318B8.7

Gene ID: 23523 | Gene type: protein coding

About CABIN1

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:24,011,304-24,178,628 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 212 orthologues. Ubiquitous expression in thyroid (RPKM 6.8), testis (RPKM 6.2) and 25 other tissues.

Summary

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of Calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]

CABIN1 Products(3)

mRNA	Protein	Name
NM_001199281.1	NP_001186210.1	calcineurin-binding protein cabin-1 isoform a
NM_001201429.2	NP_001188358.1	calcineurin-binding protein cabin-1 isoform b
NM_012295.4	NP_036427.1	calcineurin-binding protein cabin-1 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12700764	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	14718166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CABIN1 Protein Structure

TPR_11

MEF2_binding

0
400
800
1200
1600
2000
2220 a.a.

Protein Preferred Names

Protein Names

calcineurin-binding protein cabin-1

calcineurin binding protein cabin 1

CABIN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CABIN1	Q9Y6J0	MEF2B	Homo sapiens	Q02080	EMSA	12700764

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colloid Adenoma

Macrofollicular Adenoma

Adiaspiromycosis

Fetal Adenoma

Microfollicular Adenoma

Neurilemmomatosis

Schwannomatosis	Neurofibromatosis Type 3
Nf3	Neurilemmomatosis Congenital Cutaneous
Neurinomatosis	Congenital Cutaneous Neurilemmomatosis
Multiple Neurilemmomas	Multiple Schwannomas
Neurilemmomatosis, Congenital Cutaneous	Schwannomatosis 1
Neurofibromatosis 3	Mixed Central And Peripheral Neurofibromatosis
Nf3 - [Neurofibromatosis Type 3]

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01780	CABIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CABIN1	VGNC	VGNC:38621
Rattus norvegicus	CABIN1	RGD	RGD:620263
Felis catus	CABIN1	VGNC	VGNC:60283
Macaca mulatta	CABIN1	VGNC	VGNC:84563
Mus musculus	CABIN1	MGD	MGI:1298375
Bos taurus	CABIN1	VGNC	VGNC:26663

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