ACAP2 - ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 Gene

Homo sapiens

Also known as CENTB2; CNT-B2

Gene ID: 23527 | Gene type: protein coding

About ACAP2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:195,274,745-195,443,020 (from NCBI)

This gene has 15 transcripts (splice variants), 212 orthologues and 28 paralogues. Ubiquitous expression in thyroid (RPKM 13.3), lymph node (RPKM 12.2) and 25 other tissues.

Summary

Enables GTPase activator activity. Acts upstream of or within actin filament-based process. Located in ruffle. [provided by Alliance of Genome Resources, Apr 2022]

ACAP2 Products(1)

mRNA	Protein	Name
NM_012287.6	NP_036419.3	arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	11062263	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin filament-based process	IDA IDA: Inferred from direct assay	11062263	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ruffle	IDA IDA: Inferred from direct assay	11062263	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACAP2 Protein Structure

ArfGap

Ank_2

0
200
400
600
778 a.a.

Protein Preferred Names

Protein Names

arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

Arf GAP with coiled coil, ANK repeat and PH domains 2

ACAP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ACAP2	Q15057	ACAP3	Homo sapiens	Q96P50	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

ACAP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82740	ACAP2 Antibody (YA2485)	WB	Human, Hamster, Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00134	ACAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ACAP2	MGD	MGI:1925868
Canis familiaris	ACAP2	VGNC	VGNC:53055
Felis catus	ACAP2	VGNC	VGNC:59498
Rattus norvegicus	ACAP2	RGD	RGD:1562939
Bos taurus	ACAP2	VGNC	VGNC:25527
Macaca mulatta	ACAP2	VGNC	VGNC:69428

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