DNPEP - aspartyl aminopeptidase Gene

Homo sapiens

Also known as DAP; ASPEP

Gene ID: 23549 | Gene type: protein coding

About DNPEP

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,372,043-219,400,007 (from NCBI)

This gene has 21 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in small intestine (RPKM 15.5), duodenum (RPKM 15.4) and 25 other tissues.

Summary

The protein encoded by this gene is an Aminopeptidase which prefers acidic Amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

DNPEP Products(8)

mRNA	Protein	Name
NM_001319116.2	NP_001306045.1	aspartyl aminopeptidase isoform a
NM_001319117.2	NP_001306046.1	aspartyl aminopeptidase isoform b
NM_001319118.2	NP_001306047.1	aspartyl aminopeptidase isoform d
NM_001319119.2	NP_001306048.1	aspartyl aminopeptidase isoform d
NM_001319120.2	NP_001306049.1	aspartyl aminopeptidase isoform e
NM_001319121.2	NP_001306050.1	aspartyl aminopeptidase isoform f
NM_001319122.2	NP_001306051.1	aspartyl aminopeptidase isoform f
NM_012100.4	NP_036232.2	aspartyl aminopeptidase isoform c

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNPEP Protein Structure

Peptidase_M18

0
100
200
300
400
485 a.a.

Protein Preferred Names

Protein Names

aspartyl aminopeptidase

DNPEP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DNPEP	Q9ULA0	MPP1	Homo sapiens	Q00013	Validated Y2H	25416956
Intra	DNPEP	Q9ULA0	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	DNPEP	Q9ULA0	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	DNPEP	Q9ULA0	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956
Intra	DNPEP	Q9ULA0	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	DNPEP	Q9ULA0	SCAF8	Homo sapiens	Q9UPN6	Anti Tag CoIP	33961781
Intra	DNPEP	Q9ULA0	SCAF8	Homo sapiens	Q9UPN6	Anti Tag CoIP	28514442
Intra	DNPEP	Q9ULA0	TAE1	Saccharomyces cerevisiae	P38340	Validated Y2H	27107014
Intra	DNPEP	Q9ULA0	DNPEP	Homo sapiens	Q9ULA0	Y2H Prey Pooling	32296183
Intra	DNPEP	Q9ULA0	DNPEP	Homo sapiens	Q9ULA0	Validated Y2H	32296183
Intra	DNPEP	Q9ULA0	DNPEP	Homo sapiens	Q9ULA0	Y2H Array	25416956
Intra	DNPEP	Q9ULA0	DNPEP	Homo sapiens	Q9ULA0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Trichorhinophalangeal Syndrome, Type I

Trichorhinophalangeal Dysplasia Type I	TRPS1
Trichorhinophalangeal Syndrome Type I	Trps I
Trichorhinophalangeal Syndrome Type 1	Type I Trichorhinophalangeal Syndrome
Giedion Syndrome	Trp Syndrome
Tricho-Rhino-Phalangeal Syndrome 1	Trichorhinophalangeal Syndrome, Type Iii

Nemaline Myopathy 9

NEM9	Myopathy, Nemaline, Type 9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03914	DNPEP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DNPEP	VGNC	VGNC:28148
Macaca mulatta	DNPEP	VGNC	VGNC:71961
Mus musculus	DNPEP	MGD	MGI:1278328
Rattus norvegicus	DNPEP	RGD	RGD:1583848
Canis familiaris	DNPEP	VGNC	VGNC:40038
Felis catus	DNPEP	VGNC	VGNC:61564

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