2. Gene
  3. MPP1 - MAGUK p55 scaffold protein 1 Gene

MPP1 - MAGUK p55 scaffold protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MRG1; PEMP; AAG12; EMP55; DXS552E

Gene ID: 4354 | Gene type: protein coding

About MPP1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,778,684-154,805,485 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 7 paralogues. Broad expression in placenta (RPKM 52.9), bone marrow (RPKM 48.1) and 25 other tissues.

Summary

This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the Cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

MPP1 Products(4)

mRNA Protein Name
NM_001166460.2 NP_001159932.1 55 kDa erythrocyte membrane protein isoform 2
NM_001166461.2 NP_001159933.1 55 kDa erythrocyte membrane protein isoform 3
NM_001166462.2 NP_001159934.1 55 kDa erythrocyte membrane protein isoform 4
NM_002436.4 NP_002427.1 55 kDa erythrocyte membrane protein isoform 1

MPP1 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (72 - 148)

SH3_2

SH3_2: Variant SH3 domain (162 - 226)

Guanylate_kin

Guanylate_kin: Guanylate kinase (281 - 452)

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  • 466 a.a.
Protein Preferred Names Protein Names

55 kDa erythrocyte membrane protein

aging-associated gene 12

MPP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MPP1 Q00013 PRIMPOL Homo sapiens Q96LW4
Validated Y2H
32296183
Intra MPP1 Q00013 PRIMPOL Homo sapiens Q96LW4
Y2H Array
32296183
Intra MPP1 Q00013 PRIMPOL Homo sapiens Q96LW4
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra MPP1 Q00013 RPRM Homo sapiens Q9NS64
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 RPRM Homo sapiens Q9NS64
Y2H Array
32296183
Intra MPP1 Q00013 SYNGR3 Homo sapiens O43761
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 SYNGR3 Homo sapiens O43761
Y2H Array
32296183
Intra MPP1 Q00013 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 GPRASP3 Homo sapiens Q6PI77
Validated Y2H
32296183
Intra MPP1 Q00013 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra MPP1 Q00013 TMEM239 Homo sapiens Q8WW34-2
Validated Y2H
32296183
Intra MPP1 Q00013 TMEM239 Homo sapiens Q8WW34-2
Y2H Array
32296183
Intra MPP1 Q00013 TMEM239 Homo sapiens Q8WW34-2
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 ATRAID Homo sapiens Q6UW56-2
Validated Y2H
32296183
Intra MPP1 Q00013 ATRAID Homo sapiens Q6UW56-2
Y2H Array
32296183
Intra MPP1 Q00013 ATRAID Homo sapiens Q6UW56-2
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 DGAT2L6 Homo sapiens Q6ZPD8
Validated Y2H
32296183
Intra MPP1 Q00013 DGAT2L6 Homo sapiens Q6ZPD8
Y2H Array
32296183
Intra MPP1 Q00013 DGAT2L6 Homo sapiens Q6ZPD8
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 PAQR8 Homo sapiens Q8TEZ7
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 PAQR8 Homo sapiens Q8TEZ7
Validated Y2H
32296183
Intra MPP1 Q00013 PAQR8 Homo sapiens Q8TEZ7
Y2H Array
32296183
Intra MPP1 Q00013 ACER1 Homo sapiens Q8TDN7
Validated Y2H
32296183
Intra MPP1 Q00013 ACER1 Homo sapiens Q8TDN7
Y2H Array
32296183
Intra MPP1 Q00013 ACER1 Homo sapiens Q8TDN7
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 ACER2 Homo sapiens Q5QJU3-2
Y2H Array
32296183
Intra MPP1 Q00013 ACER2 Homo sapiens Q5QJU3-2
Validated Y2H
32296183
Intra MPP1 Q00013 ACER2 Homo sapiens Q5QJU3-2
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra MPP1 Q00013 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 APH1A Homo sapiens Q96BI3
Validated Y2H
32296183
Intra MPP1 Q00013 APH1A Homo sapiens Q96BI3
Y2H Array
32296183
Intra MPP1 Q00013 APH1A Homo sapiens Q96BI3
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 AGPAT3 Homo sapiens Q9NRZ7
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 AGPAT3 Homo sapiens Q9NRZ7
Y2H Array
32296183
Intra MPP1 Q00013 AGPAT3 Homo sapiens Q9NRZ7
Validated Y2H
32296183
Intra MPP1 Q00013 AP2M1 Homo sapiens Q96CW1
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 AP2M1 Homo sapiens Q96CW1
Validated Y2H
32296183
Intra MPP1 Q00013 AP2M1 Homo sapiens Q96CW1
Y2H Array
32296183
Intra MPP1 Q00013 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra MPP1 Q00013 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra MPP1 Q00013 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra MPP1 Q00013 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra MPP1 Q00013 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra MPP1 Q00013 GSN Homo sapiens P06396
Y2H Array
32814053
Intra MPP1 Q00013 UXT Homo sapiens Q9UBK9
Validated Y2H
32296183
Intra MPP1 Q00013 UXT Homo sapiens Q9UBK9
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 UXT Homo sapiens Q9UBK9
Y2H Array
32296183
Intra MPP1 Q00013 ABCC4 Homo sapiens O15439
FRAP
29146910
Intra MPP1 Q00013 ABCC4 Homo sapiens O15439
FPS
29146910
Intra MPP1 Q00013 ABCC4 Homo sapiens O15439
Competition Binding
29146910
Intra MPP1 Q00013 ABCC4 Homo sapiens O15439
Anti Tag CoIP
29146910
Intra MPP1 Q00013 ABCC4 Homo sapiens O15439
PLA
29146910
Intra MPP1 Q00013 ABCC4 Homo sapiens O15439
Pull Down
29146910
Intra MPP1 Q00013 ABCC4 Homo sapiens O15439
Anti Bait CoIP
29146910
Intra MPP1 Q00013 ABCC4 Homo sapiens O15439
FRET
29146910
Intra MPP1 Q00013 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra MPP1 Q00013 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra MPP1 Q00013 SLC35E1 Homo sapiens Q96K37
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 SLC35E1 Homo sapiens Q96K37
Validated Y2H
32296183
Intra MPP1 Q00013 SLC35E1 Homo sapiens Q96K37
Y2H Array
32296183
Intra MPP1 Q00013 KLHL12 Homo sapiens Q53G59
Y2H Array
32296183
Intra MPP1 Q00013 KLHL12 Homo sapiens Q53G59
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 KLHL12 Homo sapiens Q53G59
Validated Y2H
32296183
Intra MPP1 Q00013 DNPEP Homo sapiens Q9ULA0
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 DNPEP Homo sapiens Q9ULA0
Y2H Prey Pooling
25416956
Intra MPP1 Q00013 DNPEP Homo sapiens Q9ULA0
Validated Y2H
32296183
Intra MPP1 Q00013 DNPEP Homo sapiens Q9ULA0
Y2H Array
25416956
Intra MPP1 Q00013 DNPEP Homo sapiens Q9ULA0
Y2H Array
32296183
Intra MPP1 Q00013 DERL2 Homo sapiens Q9GZP9
Validated Y2H
32296183
Intra MPP1 Q00013 DERL2 Homo sapiens Q9GZP9
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 DERL2 Homo sapiens Q9GZP9
Y2H Array
32296183
Intra MPP1 Q00013 ZNF639 Homo sapiens Q9UID6
Y2H Array
32296183
Intra MPP1 Q00013 ZNF639 Homo sapiens Q9UID6
Y2H Prey Pooling
32296183
Intra MPP1 Q00013 ZNF639 Homo sapiens Q9UID6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ehrlichiosis

Human Ehrlichiosis

He

Hey
Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma
Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx

Npc

Nasopharyngeal Cancer

Nasopharyngeal Carcinoma 1

Nasopharynx Carcinoma

Nasopharyngeal Neoplasms

Npca

Carcinoma Of Nasopharynx

Malignant Nasopharyngeal Tumor

Nasopharynx Cancer

Squamous Cell Carcinoma Of The Nasopharynx

Nasopharyngeal Neoplasm

Cancer Of Nasopharynx
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08622 MPP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MPP1 VGNC VGNC:31582
Mus musculus MPP1 MGD MGI:105941
Macaca mulatta MPP1 VGNC VGNC:74920
Rattus norvegicus MPP1 RGD RGD:1594331
Canis familiaris MPP1 VGNC VGNC:43342
Felis catus MPP1 VGNC VGNC:101461