MPP1 - MAGUK p55 scaffold protein 1 Gene

Homo sapiens

Also known as MRG1; PEMP; AAG12; EMP55; DXS552E

Gene ID: 4354 | Gene type: protein coding

About MPP1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,778,684-154,805,485 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 7 paralogues. Broad expression in placenta (RPKM 52.9), bone marrow (RPKM 48.1) and 25 other tissues.

Summary

This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the Cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

MPP1 Products(4)

mRNA	Protein	Name
NM_001166460.2	NP_001159932.1	55 kDa erythrocyte membrane protein isoform 2
NM_001166461.2	NP_001159933.1	55 kDa erythrocyte membrane protein isoform 3
NM_001166462.2	NP_001159934.1	55 kDa erythrocyte membrane protein isoform 4
NM_002436.4	NP_002427.1	55 kDa erythrocyte membrane protein isoform 1

MPP1 Protein Structure

PDZ

SH3_2

Guanylate_kin

0
100
200
300
400
466 a.a.

Protein Preferred Names

Protein Names

55 kDa erythrocyte membrane protein

aging-associated gene 12

MPP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MPP1	Q00013	PRIMPOL	Homo sapiens	Q96LW4	Validated Y2H	32296183
Intra	MPP1	Q00013	PRIMPOL	Homo sapiens	Q96LW4	Y2H Array	32296183
Intra	MPP1	Q00013	PRIMPOL	Homo sapiens	Q96LW4	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	MPP1	Q00013	RPRM	Homo sapiens	Q9NS64	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	RPRM	Homo sapiens	Q9NS64	Y2H Array	32296183
Intra	MPP1	Q00013	SYNGR3	Homo sapiens	O43761	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	SYNGR3	Homo sapiens	O43761	Y2H Array	32296183
Intra	MPP1	Q00013	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	GPRASP3	Homo sapiens	Q6PI77	Validated Y2H	32296183
Intra	MPP1	Q00013	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	MPP1	Q00013	TMEM239	Homo sapiens	Q8WW34-2	Validated Y2H	32296183
Intra	MPP1	Q00013	TMEM239	Homo sapiens	Q8WW34-2	Y2H Array	32296183
Intra	MPP1	Q00013	TMEM239	Homo sapiens	Q8WW34-2	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	ATRAID	Homo sapiens	Q6UW56-2	Validated Y2H	32296183
Intra	MPP1	Q00013	ATRAID	Homo sapiens	Q6UW56-2	Y2H Array	32296183
Intra	MPP1	Q00013	ATRAID	Homo sapiens	Q6UW56-2	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	DGAT2L6	Homo sapiens	Q6ZPD8	Validated Y2H	32296183
Intra	MPP1	Q00013	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Array	32296183
Intra	MPP1	Q00013	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	PAQR8	Homo sapiens	Q8TEZ7	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	PAQR8	Homo sapiens	Q8TEZ7	Validated Y2H	32296183
Intra	MPP1	Q00013	PAQR8	Homo sapiens	Q8TEZ7	Y2H Array	32296183
Intra	MPP1	Q00013	ACER1	Homo sapiens	Q8TDN7	Validated Y2H	32296183
Intra	MPP1	Q00013	ACER1	Homo sapiens	Q8TDN7	Y2H Array	32296183
Intra	MPP1	Q00013	ACER1	Homo sapiens	Q8TDN7	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	ACER2	Homo sapiens	Q5QJU3-2	Y2H Array	32296183
Intra	MPP1	Q00013	ACER2	Homo sapiens	Q5QJU3-2	Validated Y2H	32296183
Intra	MPP1	Q00013	ACER2	Homo sapiens	Q5QJU3-2	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	MPP1	Q00013	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	APH1A	Homo sapiens	Q96BI3	Validated Y2H	32296183
Intra	MPP1	Q00013	APH1A	Homo sapiens	Q96BI3	Y2H Array	32296183
Intra	MPP1	Q00013	APH1A	Homo sapiens	Q96BI3	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	AGPAT3	Homo sapiens	Q9NRZ7	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	AGPAT3	Homo sapiens	Q9NRZ7	Y2H Array	32296183
Intra	MPP1	Q00013	AGPAT3	Homo sapiens	Q9NRZ7	Validated Y2H	32296183
Intra	MPP1	Q00013	AP2M1	Homo sapiens	Q96CW1	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	AP2M1	Homo sapiens	Q96CW1	Validated Y2H	32296183
Intra	MPP1	Q00013	AP2M1	Homo sapiens	Q96CW1	Y2H Array	32296183
Intra	MPP1	Q00013	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	MPP1	Q00013	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	MPP1	Q00013	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	MPP1	Q00013	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	MPP1	Q00013	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	MPP1	Q00013	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	MPP1	Q00013	UXT	Homo sapiens	Q9UBK9	Validated Y2H	32296183
Intra	MPP1	Q00013	UXT	Homo sapiens	Q9UBK9	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	UXT	Homo sapiens	Q9UBK9	Y2H Array	32296183
Intra	MPP1	Q00013	ABCC4	Homo sapiens	O15439	FRAP	29146910
Intra	MPP1	Q00013	ABCC4	Homo sapiens	O15439	FPS	29146910
Intra	MPP1	Q00013	ABCC4	Homo sapiens	O15439	Competition Binding	29146910
Intra	MPP1	Q00013	ABCC4	Homo sapiens	O15439	Anti Tag CoIP	29146910
Intra	MPP1	Q00013	ABCC4	Homo sapiens	O15439	PLA	29146910
Intra	MPP1	Q00013	ABCC4	Homo sapiens	O15439	Pull Down	29146910
Intra	MPP1	Q00013	ABCC4	Homo sapiens	O15439	Anti Bait CoIP	29146910
Intra	MPP1	Q00013	ABCC4	Homo sapiens	O15439	FRET	29146910
Intra	MPP1	Q00013	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	MPP1	Q00013	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
Intra	MPP1	Q00013	SLC35E1	Homo sapiens	Q96K37	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	SLC35E1	Homo sapiens	Q96K37	Validated Y2H	32296183
Intra	MPP1	Q00013	SLC35E1	Homo sapiens	Q96K37	Y2H Array	32296183
Intra	MPP1	Q00013	KLHL12	Homo sapiens	Q53G59	Y2H Array	32296183
Intra	MPP1	Q00013	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	KLHL12	Homo sapiens	Q53G59	Validated Y2H	32296183
Intra	MPP1	Q00013	DNPEP	Homo sapiens	Q9ULA0	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	DNPEP	Homo sapiens	Q9ULA0	Y2H Prey Pooling	25416956
Intra	MPP1	Q00013	DNPEP	Homo sapiens	Q9ULA0	Validated Y2H	32296183
Intra	MPP1	Q00013	DNPEP	Homo sapiens	Q9ULA0	Y2H Array	25416956
Intra	MPP1	Q00013	DNPEP	Homo sapiens	Q9ULA0	Y2H Array	32296183
Intra	MPP1	Q00013	DERL2	Homo sapiens	Q9GZP9	Validated Y2H	32296183
Intra	MPP1	Q00013	DERL2	Homo sapiens	Q9GZP9	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	DERL2	Homo sapiens	Q9GZP9	Y2H Array	32296183
Intra	MPP1	Q00013	ZNF639	Homo sapiens	Q9UID6	Y2H Array	32296183
Intra	MPP1	Q00013	ZNF639	Homo sapiens	Q9UID6	Y2H Prey Pooling	32296183
Intra	MPP1	Q00013	ZNF639	Homo sapiens	Q9UID6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

MPP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83332	MPP1 Antibody (YA3077)	WB	Human

Related Diseases

Diseases

Alias

Ehrlichiosis

Human Ehrlichiosis	He
Hey

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx	Npc
Nasopharyngeal Cancer	Nasopharyngeal Carcinoma 1
Nasopharynx Carcinoma	Nasopharyngeal Neoplasms
Npca	Carcinoma Of Nasopharynx
Malignant Nasopharyngeal Tumor	Nasopharynx Cancer
Squamous Cell Carcinoma Of The Nasopharynx	Nasopharyngeal Neoplasm
Cancer Of Nasopharynx

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08622	MPP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MPP1	VGNC	VGNC:31582
Mus musculus	MPP1	MGD	MGI:105941
Macaca mulatta	MPP1	VGNC	VGNC:74920
Rattus norvegicus	MPP1	RGD	RGD:1594331
Canis familiaris	MPP1	VGNC	VGNC:43342
Felis catus	MPP1	VGNC	VGNC:101461

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