2. Gene
  3. PADI4 - peptidyl arginine deiminase 4 Gene

PADI4 - peptidyl arginine deiminase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PAD; PAD4; PDI4; PDI5; PADI5

Gene ID: 23569 | Gene type: protein coding

About PADI4

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,308,197-17,364,004 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 235 orthologues and 4 paralogues. Restricted expression toward bone marrow (RPKM 64.4).

Summary

This gene is a member of a gene family which encodes Enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]

PADI4 Products(1)

mRNA Protein Name
NM_012387.3 NP_036519.2 protein-arginine deiminase type-4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
16567635 GOA
enables histone H3R17 arginine deiminase activity IDA
IDA: Inferred from direct assay
15339660 GOA
enables histone H3R2 arginine deiminase activity IDA
IDA: Inferred from direct assay
15339660 GOA
enables histone H3R26 arginine deiminase activity IDA
IDA: Inferred from direct assay
15339660 GOA
enables histone H3R8 arginine deiminase activity IDA
IDA: Inferred from direct assay
15339660 GOA
enables histone arginine deiminase activity IDA
IDA: Inferred from direct assay
16567635 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
15247907 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein-arginine deiminase activity IDA
IDA: Inferred from direct assay
21584310 GOA
enables protein-arginine deiminase activity IMP
IMP: Inferred from mutant phenotype
15247907 GOA
Biological Process GO Annotation Evidence Reference Source
involved in post-translational protein modification IDA
IDA: Inferred from direct assay
15339660 GOA
involved in post-translational protein modification IMP
IMP: Inferred from mutant phenotype
15247907 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
15339660 GOA
part of protein-containing complex IMP
IMP: Inferred from mutant phenotype
15247907 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PADI4 Protein Structure

PAD_N

PAD_N: Protein-arginine deiminase (PAD) N-terminal domain (1 - 111)

PAD_M

PAD_M: Protein-arginine deiminase (PAD) middle domain (113 - 273)

PAD

PAD: Protein-arginine deiminase (PAD) (278 - 663)

  • 0
  • 200
  • 400
  • 600
  • 663 a.a.
Protein Preferred Names Protein Names

protein-arginine deiminase type-4

HL-60 PAD

Recombinant PADI4 Proteins

Cat. No. Product Name Accession Purity
HY-P70990 PADI4 Protein, Human (His) Q9UM07/AAH25718.1 (M1-P663) ≥95%
HY-P77121 PADI4 Protein, Human (sf9, His) Q9UM07/AAH25718.1 (M1-P663) ≥95%
HY-P701030 PADI4 Protein, Human (Biotinylated, His) Q9UM07/AAH25718.1 (M1-P663) ≥95%

Related Diseases

Diseases Alias
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Felty Syndrome

Felty'S Syndrome

Rheumatoid Arthritis With Splenoadenomegaly And Leukopenia

Familial Felty'S Syndrome

Rheumatoid Arthritis, Splenomegaly And Neutropenia

Splenomegaly-Neutropenia-Rheumatoid Arthritis Syndrome

Feltys Syndrome
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Caplan'S Syndrome

Caplan Syndrome

Caplan'S Disease

Caplans Syndrome

Rheumatoid Pneumoconiosis
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Cervical Polyp

Cervix Adenomatous Polyp
Papillon-Lefevre Syndrome

Papillon-Lefevre Disease

Papillon-Lefèvre Syndrome

PLS

Keratosis Palmoplantaris With Periodontopathia

PALS

Papillon Lefevre Syndrome

Keratosis Palmoplantar-Periodontopathy Syndrome

Papillon-Lefvre Syndrome

Hyperkeratosis Palmoplantaris With Periodontosis

Keratoris Palmoplantaris With Periodontopathia

Keratosis Palmoplantar - Periodontopathy

Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction

Palmoplantar Keratoderma With Periodontosis

Palsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09963 PADI4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PADI4 VGNC VGNC:80298
Canis familiaris PADI4 VGNC VGNC:44237
Macaca mulatta PADI4 VGNC VGNC:100024
Rattus norvegicus PADI4 RGD RGD:3290
Bos taurus PADI4 VGNC VGNC:32548
Mus musculus PADI4 MGD MGI:1338898
Macaca fascicularis PADI4 NCBI NCBI:102126460
Others PADI4 NCBI