2. Gene
  3. POU6F2 - POU class 6 homeobox 2 Gene

POU6F2 - POU class 6 homeobox 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as WT5; WTSL; RPF-1

Gene ID: 11281 | Gene type: protein coding

About POU6F2

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:38,977,909-39,468,601 (from NCBI)

This gene has 12 transcripts (splice variants), 218 orthologues, 17 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

POU6F2 Products(3)

mRNA Protein Name
NM_001166018.2 NP_001159490.1 POU domain, class 6, transcription factor 2 isoform 2
NM_001370959.1 NP_001357888.1 POU domain, class 6, transcription factor 2 isoform 3
NM_007252.4 NP_009183.3 POU domain, class 6, transcription factor 2 isoform 1

POU6F2 Protein Structure

Pou

Pou: Pou domain - N-terminal to homeobox domain (478 - 525)

Pou

Pou: Pou domain - N-terminal to homeobox domain (560 - 586)

Homeobox

Homeobox: Homeobox domain (608 - 663)

  • 0
  • 200
  • 400
  • 600
  • 691 a.a.
Protein Preferred Names Protein Names

POU domain, class 6, transcription factor 2

Wilms tumor suppressor locus

POU6F2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
POU6F2 P78424 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra
POU6F2 P78424 CHAF1A Homo sapiens Q13111
Validated Y2H
32296183
Intra
POU6F2 P78424 IQUB Homo sapiens Q8NA54
Validated Y2H
32296183
Intra
POU6F2 P78424 MYL7 Homo sapiens Q01449
Validated Y2H
32296183
Intra
POU6F2 P78424 BFSP2 Homo sapiens Q13515
Validated Y2H
32296183
Intra
POU6F2 P78424 PDE6H Homo sapiens Q13956
Validated Y2H
32296183
Intra
POU6F2 P78424 ZFHX3 Homo sapiens Q15911-2
Validated Y2H
32296183
Intra
POU6F2 P78424 FNDC3B Homo sapiens Q53EP0-3
Validated Y2H
32296183
Intra
POU6F2 P78424 TRIM74 Homo sapiens Q86UV6-2
Validated Y2H
32296183
Intra
POU6F2 P78424 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra
POU6F2 P78424 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 KRTAP8-1 Homo sapiens Q8IUC2
Validated Y2H
32296183
Intra
POU6F2 P78424 CIB3 Homo sapiens Q96Q77
Validated Y2H
32296183
Intra
POU6F2 P78424 NEUROG3 Homo sapiens Q9Y4Z2
Validated Y2H
32296183
Intra
POU6F2 P78424 PADI4 Homo sapiens Q9UM07
Validated Y2H
32296183
Intra
POU6F2 P78424 RELA Homo sapiens Q96CP1
Validated Y2H
32296183
Intra
POU6F2 P78424 MSRB3 Homo sapiens Q8IXL7-2
Validated Y2H
32296183
Intra
POU6F2 P78424 TRIML2 Homo sapiens Q8N7C3
Validated Y2H
32296183
Intra
POU6F2 P78424 PM20D2 Homo sapiens Q8IYS1
Validated Y2H
32296183
Intra
POU6F2 P78424 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
POU6F2 P78424 POU2F1 Homo sapiens P14859-6
Y2H Array
32296183
Intra
POU6F2 P78424 POU2F1 Homo sapiens P14859-6
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 SORL1 Homo sapiens Q92673
Validated Y2H
32296183
Intra
POU6F2 P78424 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
Intra
POU6F2 P78424 ZNF148 Homo sapiens Q9UQR1-2
Validated Y2H
32296183
Intra
POU6F2 P78424 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra
POU6F2 P78424 HOXC5 Homo sapiens Q00444
Validated Y2H
32296183
Intra
POU6F2 P78424 IGFN1 Homo sapiens Q86VF2-5
Validated Y2H
32296183
Intra
POU6F2 P78424 NFYC Homo sapiens Q13952-2
Validated Y2H
32296183
Intra
POU6F2 P78424 ZIM2 Homo sapiens Q9NZV7
Validated Y2H
32296183
Intra
POU6F2 P78424 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
Intra
POU6F2 P78424 VEZF1 Homo sapiens Q14119
Validated Y2H
32296183
Intra
POU6F2 P78424 ZNF319 Homo sapiens Q9P2F9
Validated Y2H
32296183
Intra
POU6F2 P78424 KDF1 Homo sapiens Q8NAX2
Validated Y2H
32296183
Intra
POU6F2 P78424 ASB13 Homo sapiens Q8WXK3-2
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 ASB13 Homo sapiens Q8WXK3-2
Validated Y2H
32296183
Intra
POU6F2 P78424 ASB13 Homo sapiens Q8WXK3-2
Y2H Array
32296183
Intra
POU6F2 P78424 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
POU6F2 P78424 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
POU6F2 P78424 STRA8 Homo sapiens Q7Z7C7
Validated Y2H
32296183
Intra
POU6F2 P78424 OAZ3 Homo sapiens Q9UMX2-2
Validated Y2H
32296183
Intra
POU6F2 P78424 UFSP1 Homo sapiens Q6NVU6
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 UFSP1 Homo sapiens Q6NVU6
Validated Y2H
32296183
Intra
POU6F2 P78424 UFSP1 Homo sapiens Q6NVU6
Y2H Array
32296183
Intra
POU6F2 P78424 LARP4 Homo sapiens Q6P4E2
Validated Y2H
32296183
Intra
POU6F2 P78424 VAX2 Homo sapiens Q9UIW0
Validated Y2H
32296183
Intra
POU6F2 P78424 ANKRD10 Homo sapiens Q9NXR5-2
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 ANKRD10 Homo sapiens Q9NXR5-2
Validated Y2H
32296183
Intra
POU6F2 P78424 ANKRD10 Homo sapiens Q9NXR5-2
Y2H Array
32296183
Intra
POU6F2 P78424 SSUH2 Homo sapiens Q9Y2M2-2
Validated Y2H
32296183
Intra
POU6F2 P78424 THADA Homo sapiens Q6YHU6-6
Validated Y2H
32296183
Intra
POU6F2 P78424 PLAAT1 Homo sapiens Q9HDD0
Validated Y2H
32296183
Intra
POU6F2 P78424 PLAAT1 Homo sapiens Q9HDD0
Y2H Array
32296183
Intra
POU6F2 P78424 PLAAT1 Homo sapiens Q9HDD0
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 PRR20D Homo sapiens P86480
Validated Y2H
32296183
Intra
POU6F2 P78424 PRR20D Homo sapiens P86480
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 PRR20D Homo sapiens P86480
Y2H Array
32296183
Intra
POU6F2 P78424 TSC1 Homo sapiens Q86WV8
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 TSC1 Homo sapiens Q86WV8
Validated Y2H
32296183
Intra
POU6F2 P78424 TSC1 Homo sapiens Q86WV8
Y2H Array
32296183
Intra
POU6F2 P78424 MLLT10 Homo sapiens P55197-2
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 MLLT10 Homo sapiens P55197-2
Y2H Array
32296183
Intra
POU6F2 P78424 PPIP5K2 Homo sapiens O43314-2
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 PPIP5K2 Homo sapiens O43314-2
Y2H Array
32296183
Intra
POU6F2 P78424 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 PIBF1 Homo sapiens Q4G0R1
Validated Y2H
32296183
Intra
POU6F2 P78424 ARHGEF6 Homo sapiens Q15052
Validated Y2H
32296183
Intra
POU6F2 P78424 ZNF574 Homo sapiens Q6ZN55-2
Validated Y2H
32296183
Intra
POU6F2 P78424 LONRF1 Homo sapiens Q17RB8
Validated Y2H
32296183
Intra
POU6F2 P78424 ZFP1 Homo sapiens Q6P2D0
Validated Y2H
32296183
Intra
POU6F2 P78424 PPIL1 Homo sapiens Q9Y3C6
Validated Y2H
32296183
Intra
POU6F2 P78424 ZBTB4 Homo sapiens Q9P1Z0
Validated Y2H
32296183
Intra
POU6F2 P78424 STAC Homo sapiens Q99469
Validated Y2H
32296183
Intra
POU6F2 P78424 KLHL11 Homo sapiens Q9NVR0
Validated Y2H
32296183
Intra
POU6F2 P78424 QRICH1 Homo sapiens Q2TAL8
Validated Y2H
32296183
Intra
POU6F2 P78424 FOSB Homo sapiens P53539
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 FOSB Homo sapiens P53539
Y2H Array
32296183
Intra
POU6F2 P78424 LMNB2 Homo sapiens Q03252
Validated Y2H
32296183
Intra
POU6F2 P78424 ACTN3 Homo sapiens Q08043
Validated Y2H
32296183
Intra
POU6F2 P78424 CDC37 Homo sapiens Q16543
Validated Y2H
32296183
Intra
POU6F2 P78424 KPNA6 Homo sapiens O60684
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 KPNA6 Homo sapiens O60684
Y2H Array
32296183
Intra
POU6F2 P78424 TSEN15 Homo sapiens Q8WW01
Validated Y2H
32296183
Intra
POU6F2 P78424 PARVG Homo sapiens Q9HBI0
Validated Y2H
32296183
Intra
POU6F2 P78424 RBM39 Homo sapiens Q14498
Validated Y2H
32296183
Intra
POU6F2 P78424 CDC23 Homo sapiens Q9UJX2
Validated Y2H
32296183
Intra
POU6F2 P78424 TP53BP1 Homo sapiens Q12888
Y2H Array
32296183
Intra
POU6F2 P78424 TP53BP1 Homo sapiens Q12888
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 TP53BP1 Homo sapiens Q12888
Validated Y2H
32296183
Intra
POU6F2 P78424 MORF4L2 Homo sapiens Q15014
Validated Y2H
32296183
Intra
POU6F2 P78424 KPNA5 Homo sapiens O15131
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 KPNA5 Homo sapiens O15131
Y2H Array
32296183
Intra
POU6F2 P78424 POLR3C Homo sapiens Q9BUI4
Validated Y2H
32296183
Intra
POU6F2 P78424 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
POU6F2 P78424 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 PKN1 Homo sapiens Q16512
Validated Y2H
32296183
Intra
POU6F2 P78424 MIEN1 Homo sapiens Q9BRT3
Validated Y2H
32296183
Intra
POU6F2 P78424 SMAD5 Homo sapiens Q99717
Validated Y2H
32296183
Intra
POU6F2 P78424 ISX Homo sapiens Q2M1V0
Validated Y2H
32296183
Intra
POU6F2 P78424 MSX2 Homo sapiens P35548
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 MSX2 Homo sapiens P35548
Y2H Array
32296183
Intra
POU6F2 P78424 FHL2 Homo sapiens Q14192
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 FHL2 Homo sapiens Q14192
Validated Y2H
32296183
Intra
POU6F2 P78424 FHL2 Homo sapiens Q14192
Y2H Array
32296183
Intra
POU6F2 P78424 TCEA2 Homo sapiens Q15560
Validated Y2H
32296183
Intra
POU6F2 P78424 CDKN2C Homo sapiens P42773
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 EIF3F Homo sapiens O00303
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 EIF3F Homo sapiens O00303
Y2H Array
32296183
Intra
POU6F2 P78424 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra
POU6F2 P78424 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 GLIS2 Homo sapiens Q9BZE0
Validated Y2H
32296183
Intra
POU6F2 P78424 CINP Homo sapiens Q9BW66
Validated Y2H
32296183
Intra
POU6F2 P78424 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
POU6F2 P78424 L3MBTL2 Homo sapiens Q969R5
Validated Y2H
32296183
Intra
POU6F2 P78424 RBPMS Homo sapiens Q93062-3
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 RBPMS Homo sapiens Q93062-3
Validated Y2H
32296183
Intra
POU6F2 P78424 RBPMS Homo sapiens Q93062-3
Y2H Array
32296183
Intra
POU6F2 P78424 DYDC1 Homo sapiens Q8WWB3
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 DYDC1 Homo sapiens Q8WWB3
Validated Y2H
32296183
Intra
POU6F2 P78424 DYDC1 Homo sapiens Q8WWB3
Y2H Array
32296183
Intra
POU6F2 P78424 EIF4EBP1 Homo sapiens Q13541
Validated Y2H
32296183
Intra
POU6F2 P78424 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra
POU6F2 P78424 SIX1 Homo sapiens Q15475
Validated Y2H
32296183
Intra
POU6F2 P78424 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
Intra
POU6F2 P78424 OPTN Homo sapiens Q96CV9
Validated Y2H
32296183
Intra
POU6F2 P78424 UBAC1 Homo sapiens Q9BSL1
Validated Y2H
32296183
Intra
POU6F2 P78424 MAGEA12 Homo sapiens P43365
Y2H Array
32296183
Intra
POU6F2 P78424 MAGEA12 Homo sapiens P43365
Y2H Prey Pooling
32296183
Intra
POU6F2 P78424 NUP62CL Homo sapiens Q9H1M0
Validated Y2H
32296183
Intra
POU6F2 P78424 TENT5B Homo sapiens Q96A09
Validated Y2H
32296183
Intra
POU6F2 P78424 EBF1 Homo sapiens Q9UH73
Validated Y2H
32296183
Intra
POU6F2 P78424 SMYD1 Homo sapiens Q8NB12
Validated Y2H
32296183
Intra
POU6F2 P78424 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra
POU6F2 P78424 VPS9D1 Homo sapiens Q9Y2B5
Validated Y2H
32296183
Intra
POU6F2 P78424 TTC23 Homo sapiens Q5W5X9-3
Validated Y2H
32296183
Intra
POU6F2 P78424 GMEB2 Homo sapiens Q9UKD1
Validated Y2H
32296183
Intra
POU6F2 P78424 TTC19 Homo sapiens Q6DKK2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Wilms Tumor 5

Wilms Tumor

WT5

Wilms Tumor Susceptibility-5

Wilms Tumor And Radial Bilateral Aplasia

Nephroblastoma

Wilms' Tumor

Wilms Tumor, Susceptibility To

Wtsl

Bilateral Radial Aplasia With Wilms Tumor

Embryonal Adenosarcoma

Embryonal Nephroma

Kidney Wilms Tumor

Kidney, Adenomyosarcoma, Embryonal

Kidney, Carcinosarcoma, Embryonal

Kidney, Embryoma

Kidney, Embryonal Mixed Tumor

Nephroma

Renal Adenosarcoma

Renal Cancer, Wilms

Renal Wilms Tumor

Tumor, Wilms

Hereditary Susceptibility To Wilms Tumor 5
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type

Wilson-Turner Syndrome

WTS

Mrxs6

X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome

Mrxswt

Wilson-Turner X-Linked Mental Retardation Syndrome

Mental Retardation, X-Linked, Syndromic 6

Mental Retardation, X-Linked, With Gynecomastia And Obesity

Intellectual Disability, X-Linked, Syndromic 6

Intellectual Disability, X-Linked, With Gynecomastia And Obesity

Wilson Turner Intellectual Disability Syndrome

X-Linked Intellectual Disability - Gynecomastia - Obesity
Syndromic X-Linked Intellectual Disability

X-Linked Syndromic Intellectual Disability
Syndromic Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10913 POU6F2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta POU6F2 VGNC VGNC:76093
Rattus norvegicus POU6F2 RGD RGD:1584652
Felis catus POU6F2 VGNC VGNC:102664
Mus musculus POU6F2 MGD MGI:2443631