2. Gene
  3. ANXA4 - annexin A4 Gene

ANXA4 - annexin A4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ANX4; P32.5; PIG28; PP4-X; ZAP36; PAP-II; HEL-S-274

Gene ID: 307 | Gene type: protein coding

About ANXA4

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:69,643,808-69,827,112 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 12 paralogues. Broad expression in gall bladder (RPKM 187.6), duodenum (RPKM 64.1) and 17 other tissues.

Summary

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits Phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

ANXA4 Products(5)

mRNA Protein Name
NM_001153.5 NP_001144.1 annexin A4 isoform a
NM_001320698.2 NP_001307627.1 annexin A4 isoform a
NM_001320700.2 NP_001307629.1 annexin A4 isoform b
NM_001320702.2 NP_001307631.1 annexin A4 isoform c
NM_001365496.2 NP_001352425.1 annexin A4 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
20237821 GOA
enables calcium ion binding IDA
IDA: Inferred from direct assay
20237821 GOA
enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
2138016 GOA
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
15226301 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16687573 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence Reference Source
involved in epithelial cell differentiation IEP
IEP: Inferred from expression pattern
21492153 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
20237821 GOA
involved in negative regulation of interleukin-8 production IMP
IMP: Inferred from mutant phenotype
22056994 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20237821 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
22056994 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
20237821 GOA
located in nuclear membrane IDA
IDA: Inferred from direct assay
16687573 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16687573 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16687573 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16687573 GOA
located in vesicle membrane IDA
IDA: Inferred from direct assay
16687573 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANXA4 Protein Structure

Annexin

Annexin: Annexin (20 - 83)

Annexin

Annexin: Annexin (92 - 157)

Annexin

Annexin: Annexin (175 - 241)

Annexin

Annexin: Annexin (251 - 316)

  • 0
  • 100
  • 200
  • 300
  • 321 a.a.
Protein Preferred Names Protein Names

annexin A4

35-beta calcimedin

ANXA4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra ANXA4 P09525 FKBP1A Homo sapiens Q0VDC6
Validated Y2H
32814053
Intra ANXA4 P09525 FKBP1A Homo sapiens Q0VDC6
Y2H Array
32814053
Intra ANXA4 P09525 FKBP1A Homo sapiens Q0VDC6
Y2H Pooling
32814053
Intra ANXA4 P09525 PADI4 Homo sapiens Q9UM07
Y2H Array
32296183
Intra ANXA4 P09525 PADI4 Homo sapiens Q9UM07
Y2H Prey Pooling
32296183
Intra ANXA4 P09525 PADI4 Homo sapiens Q9UM07
Validated Y2H
32296183
Intra ANXA4 P09525 SARS1 Homo sapiens P49591
Validated Y2H
32814053
Intra ANXA4 P09525 SARS1 Homo sapiens P49591
Y2H Array
32814053
Intra ANXA4 P09525 SARS1 Homo sapiens P49591
Y2H Pooling
32814053
Intra ANXA4 P09525 BDNF Homo sapiens P23560-2
Y2H Array
32814053
Intra ANXA4 P09525 BDNF Homo sapiens P23560-2
Y2H Pooling
32814053
Intra ANXA4 P09525 BDNF Homo sapiens P23560-2
Validated Y2H
32814053
Intra ANXA4 P09525 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra ANXA4 P09525 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra ANXA4 P09525 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra ANXA4 P09525 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
Intra ANXA4 P09525 TINF2 Homo sapiens Q9BSI4
BiFC
21044950
Intra ANXA4 P09525 CRYAB Homo sapiens P02511
Y2H Array
32814053
Intra ANXA4 P09525 CRYAB Homo sapiens P02511
Y2H Pooling
32814053
Intra ANXA4 P09525 CRYAB Homo sapiens P02511
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00764 ANXA4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ANXA4 VGNC VGNC:37941
Macaca mulatta ANXA4 VGNC VGNC:69949
Mus musculus ANXA4 MGD MGI:88030
Bos taurus ANXA4 VGNC VGNC:25966
Felis catus ANXA4 VGNC VGNC:79989
Rattus norvegicus ANXA4 RGD RGD:621171
Others ANXA4 NCBI