2. Gene
  3. DAPK2 - death associated protein kinase 2 Gene

DAPK2 - death associated protein kinase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DRP1; DRP-1

Gene ID: 23604 | Gene type: protein coding

About DAPK2

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:63,907,036-64,046,485 (from NCBI)

This gene has 13 transcripts (splice variants), 202 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 7.0), lung (RPKM 4.4) and 18 other tissues.

Summary

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell Apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

DAPK2 Products(20)

mRNA Protein Name
NM_001363730.2 NP_001350659.1 death-associated protein kinase 2 isoform 2
NM_001384997.1 NP_001371926.1 death-associated protein kinase 2 isoform 3
NM_001384998.1 NP_001371927.1 death-associated protein kinase 2 isoform 4
NM_001384999.1 NP_001371928.1 death-associated protein kinase 2 isoform 5
NM_001385000.1 NP_001371929.1 death-associated protein kinase 2 isoform 6
NM_001395279.1 NP_001382208.1 death-associated protein kinase 2 isoform 7
NM_001395281.1 NP_001382210.1 death-associated protein kinase 2 isoform 8
NM_001395282.1 NP_001382211.1 death-associated protein kinase 2 isoform 4
NM_001395283.1 NP_001382212.1 death-associated protein kinase 2 isoform 8
NM_001395284.1 NP_001382213.1 death-associated protein kinase 2 isoform 9
NM_001395285.1 NP_001382214.1 death-associated protein kinase 2 isoform 10
NM_001395286.1 NP_001382215.1 death-associated protein kinase 2 isoform 11
NM_001395287.1 NP_001382216.1 death-associated protein kinase 2 isoform 11
NM_001395288.1 NP_001382217.1 death-associated protein kinase 2 isoform 12
NM_001395289.1 NP_001382218.1 death-associated protein kinase 2 isoform 9
NM_001395290.1 NP_001382219.1 death-associated protein kinase 2 isoform 13 precursor
NM_001395291.1 NP_001382220.1 death-associated protein kinase 2 isoform 14
NM_001395292.1 NP_001382221.1 death-associated protein kinase 2 isoform 9
NM_001395293.1 NP_001382222.1 death-associated protein kinase 2 isoform 15
NM_014326.5 NP_055141.2 death-associated protein kinase 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
10376525 GOA
enables calmodulin binding IDA
IDA: Inferred from direct assay
10376525 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
10629061 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21408167 GOA
Biological Process GO Annotation Evidence Reference Source
involved in anoikis IMP
IMP: Inferred from mutant phenotype
18957423 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
10376525 GOA
involved in positive regulation of eosinophil chemotaxis IMP
IMP: Inferred from mutant phenotype
24163421 GOA
involved in positive regulation of neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
24163421 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10376525 GOA
involved in regulation of intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
10376525 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10376525 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAPK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (23 - 285)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

death-associated protein kinase 2

DAP kinase 2

DAPK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DAPK2 Q9UIK4 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
DAPK2 Q9UIK4 FAM9B Homo sapiens Q8IZU0
Y2H Array
31515488
Intra
DAPK2 Q9UIK4 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra
DAPK2 Q9UIK4 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
DAPK2 Q9UIK4 CCDC91 Homo sapiens Q7Z6B0-2
Y2H Prey Pooling
32296183
Intra
DAPK2 Q9UIK4 CCDC91 Homo sapiens Q7Z6B0-2
Y2H Array
32296183
Intra
DAPK2 Q9UIK4 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
DAPK2 Q9UIK4 DAPK2 Homo sapiens Q9UIK4
GMS
11230133
Intra
DAPK2 Q9UIK4 DAPK2 Homo sapiens Q9UIK4
Anti Tag CoIP
10629061
Cross: Cross-species interaction Intra: Intraspecies interaction

DAPK2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82898 DAPK2 Antibody (YA2643) WB, IHC-P Rat

Related Diseases

Diseases Alias
Charcot-Marie-Tooth Disease Type 2a2b

Severe Early-Onset Axonal Neuropathy Due To Mfn2 Deficiency

Ar-Cmt2, Ouvrier Type

Autosomal Recessive Charcot-Marie-Tooth Disease, Ouvrier Type

Seoan Due To Mfn2 Deficiency

Charcot-Marie-Tooth Disease, Axonal, Type 2a2b

Cmt2a2b

Charcot-Marie-Tooth Disease, Type 2a2b
Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-131909 CJ-2360 Inhibitor / Unkown
HY-RS03528 DAPK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DAPK2 VGNC VGNC:55109
Felis catus DAPK2 VGNC VGNC:80992
Macaca mulatta DAPK2 VGNC VGNC:71733
Mus musculus DAPK2 MGD MGI:1341297
Canis familiaris DAPK2 VGNC VGNC:59108
Rattus norvegicus DAPK2 RGD RGD:1304708
Others DAPK2 NCBI