POLA2 - DNA polymerase alpha 2, accessory subunit Gene

Homo sapiens

Gene ID: 23649 | Gene type: protein coding

About POLA2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,261,962-65,305,985 (from NCBI)

This gene has 8 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in lymph node (RPKM 4.3), appendix (RPKM 2.9) and 25 other tissues.

Summary

Predicted to enable DNA binding activity. Involved in DNA replication, synthesis of RNA primer. Located in cytosol and nucleoplasm. Part of alpha DNA polymerase:primase complex. [provided by Alliance of Genome Resources, Apr 2022]

POLA2 Products(1)

mRNA	Protein	Name
NM_002689.4	NP_002680.2	DNA polymerase alpha subunit B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32353859	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA replication initiation	IDA IDA: Inferred from direct assay	26975377	GOA
involved in DNA replication, synthesis of primer	IDA IDA: Inferred from direct assay	8026492	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of alpha DNA polymerase:primase complex	IDA IDA: Inferred from direct assay	8026492	GOA
part of alpha DNA polymerase:primase complex	IPI IPI: Inferred from physical interaction	26975377	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLA2 Protein Structure

Pol_alpha_B_N

DNA_pol_E_B

0
100
200
300
400
500
598 a.a.

Protein Preferred Names

Protein Names

DNA polymerase alpha subunit B

DNA polymerase alpha 70 kDa subunit

POLA2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	POLA2	Q14181	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	POLA2	Q14181	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	POLA2	Q14181	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	POLA2	Q14181	SARS1	Homo sapiens	P49591	Validated Y2H	32814053
Intra	POLA2	Q14181	SARS1	Homo sapiens	P49591	Y2H Pooling	32814053
Intra	POLA2	Q14181	SARS1	Homo sapiens	P49591	Y2H Array	32814053
Cross	POLA2	Q14181	P0DTD1-PRO_0000449619	SARS-CoV-2	P0DTD1-PRO_0000449619	Y2H Array	36217030
Intra	POLA2	Q14181	ERN1	Homo sapiens	O75460-2	Y2H Array	32814053
Intra	POLA2	Q14181	ERN1	Homo sapiens	O75460-2	Y2H Pooling	32814053
Intra	POLA2	Q14181	ERN1	Homo sapiens	O75460-2	Validated Y2H	32814053
Intra	POLA2	Q14181	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053
Intra	POLA2	Q14181	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	POLA2	Q14181	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10817	POLA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	POLA2	MGD	MGI:99690
Felis catus	POLA2	VGNC	VGNC:81958
Macaca mulatta	POLA2	VGNC	VGNC:101380
Rattus norvegicus	POLA2	RGD	RGD:621817
Canis familiaris	POLA2	VGNC	VGNC:44772
Bos taurus	POLA2	VGNC	VGNC:33111

Name
Email *

	Sorry, but the email address you supplied was invalid.