SARS1 - seryl-tRNA synthetase 1 Gene

Homo sapiens

Also known as SARS; SERS; SERRS; NEDMAS

Gene ID: 6301 | Gene type: protein coding

About SARS1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,213,893-109,238,182 (from NCBI)

This gene has 6 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 44.0), brain (RPKM 25.3) and 25 other tissues.

Summary

This gene belongs to the class II amino-acyl tRNA family. The encoded Enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to Bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

SARS1 Products(2)

mRNA	Protein	Name
NM_001330669.1	NP_001317598.1	serine--tRNA ligase, cytoplasmic isoform b
NM_006513.4	NP_006504.2	serine--tRNA ligase, cytoplasmic isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24940000	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	28655767	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	34268557	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26433229	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	26433229	GOA
enables selenocysteine-tRNA ligase activity	IMP IMP: Inferred from mutant phenotype	34570399	GOA
enables serine-tRNA ligase activity	IDA IDA: Inferred from direct assay	24095058	GOA
enables serine-tRNA ligase activity	IMP IMP: Inferred from mutant phenotype	34570399	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic translation	IMP IMP: Inferred from mutant phenotype	36041817	GOA
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	24940000	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24940000	GOA
involved in negative regulation of vascular endothelial growth factor production	IDA IDA: Inferred from direct assay	24940000	GOA
involved in selenocysteine incorporation	IMP IMP: Inferred from mutant phenotype	34570399	GOA
involved in seryl-tRNA aminoacylation	IDA IDA: Inferred from direct assay	24095058	GOA
involved in seryl-tRNA aminoacylation	IMP IMP: Inferred from mutant phenotype	28236339	GOA
involved in tRNA modification	IDA IDA: Inferred from direct assay	34268557	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28236339	GOA
located in cytosol	IDA IDA: Inferred from direct assay	34570399	GOA
located in nucleus	IDA IDA: Inferred from direct assay	34570399	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SARS1 Protein Structure

Seryl_tRNA_N

tRNA-synt_2b

0
100
200
300
400
514 a.a.

Protein Preferred Names

Protein Names

serine--tRNA ligase, cytoplasmic

serine tRNA ligase 1, cytoplasmic

SARS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SARS1	P49591	SERTAD4	Homo sapiens	Q9NUC0	Validated Y2H	32814053
Intra	SARS1	P49591	SERTAD4	Homo sapiens	Q9NUC0	Y2H Pooling	32814053
Intra	SARS1	P49591	SERTAD4	Homo sapiens	Q9NUC0	Y2H Array	32814053
Intra	SARS1	P49591	TMEM61	Homo sapiens	Q8N0U2	Y2H Array	32814053
Intra	SARS1	P49591	TMEM61	Homo sapiens	Q8N0U2	Y2H Pooling	32814053
Intra	SARS1	P49591	TMEM61	Homo sapiens	Q8N0U2	Validated Y2H	32814053
Intra	SARS1	P49591	SWAP70	Homo sapiens	Q9UH65	Y2H Pooling	32814053
Intra	SARS1	P49591	SWAP70	Homo sapiens	Q9UH65	Validated Y2H	32814053
Intra	SARS1	P49591	SWAP70	Homo sapiens	Q9UH65	Y2H Array	32814053
Intra	SARS1	P49591	SOCS6	Homo sapiens	O14544	Y2H Pooling	32814053
Intra	SARS1	P49591	SOCS6	Homo sapiens	O14544	Validated Y2H	32814053
Intra	SARS1	P49591	SOCS6	Homo sapiens	O14544	Y2H Array	32814053
Intra	SARS1	P49591	RASSF1	Homo sapiens	Q9NS23-4	Y2H Array	32814053
Intra	SARS1	P49591	RASSF1	Homo sapiens	Q9NS23-4	Validated Y2H	32814053
Intra	SARS1	P49591	RASSF1	Homo sapiens	Q9NS23-4	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Microcephaly, Ataxia, And Seizures

NEDMAS

Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation	Intracranial Arteriovenous Malformation
Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To	Intracranial Arteriovenous Malformations
Bavm	Cerebral Arteriovenous Malformations
Intracranial Hemorrhage In Brain Cerebrovascular Malformations	Arteriovenous Malformation Of The Brain, Somatic
Intracranial Avm	Arteriovenous Malformations Cerebral

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Hyperuricemia

Blood Urate Raized

Uricacidemia

Joubert Syndrome 7

JBTS7	Cerebello-Oculo-Renal Syndrome 3
Cors3	Joubert Syndrome, Type 7

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0205B	Saralasin TFA	Antagonist	99.65%	Unkown
HY-P1564A	[Sar1, Ile8]-Angiotensin II TFA		99.70%	Unkown
HY-P0205	Saralasin	Antagonist	/	Unkown
HY-P0205A	Saralasin acetate hydrate	Antagonist	/	Unkown
HY-P1564	[Sar1, Ile8]-Angiotensin II		/	Unkown

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4685	(Sar1,Ile4,8)-Angiotensin II	Agonist	98.69%	Unkown
HY-P3138	(Sar1)-Angiotensin II	Agonist	99.84%	Unkown
HY-P10640	[Sar1,Thr8]-Angiotensin II	Antagonist	/	Unkown
HY-RS12442	SAR1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12443	SAR1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12448	SARS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-101823A	A-81282	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SARS1	MGD	MGI:102809
Bos taurus	SARS1	VGNC	VGNC:34291
Canis familiaris	SARS1	VGNC	VGNC:45869
Rattus norvegicus	SARS1	RGD	RGD:628813
Macaca mulatta	SARS1	VGNC	VGNC:100131

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