IL17RA - interleukin 17 receptor A Gene

Homo sapiens

Also known as CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R

Gene ID: 23765 | Gene type: protein coding

About IL17RA

Cytogenetic location: 22q11.1 Genomic coordinates (GRCh38): 22:17,085,000-17,115,693 (from NCBI)

This gene has 8 transcripts (splice variants), 241 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 11.6), appendix (RPKM 5.9) and 25 other tissues.

Summary

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other Cytokine Receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

IL17RA Products(2)

mRNA	Protein	Name
NM_001289905.2	NP_001276834.1	interleukin-17 receptor A isoform 2 precursor
NM_014339.7	NP_055154.3	interleukin-17 receptor A isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables interleukin-17 receptor activity	IDA IDA: Inferred from direct assay	27184415	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21993848	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fibroblast activation	IDA IDA: Inferred from direct assay	21145111	GOA
involved in interleukin-17-mediated signaling pathway	IDA IDA: Inferred from direct assay	33723527	GOA
involved in interleukin-17-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21350122	GOA
involved in interleukin-17A-mediated signaling pathway	IDA IDA: Inferred from direct assay	9367539	GOA
involved in positive regulation of chemokine (C-X-C motif) ligand 1 production	IMP IMP: Inferred from mutant phenotype	21350122	GOA
involved in positive regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	33723527	GOA
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	33723527	GOA
involved in positive regulation of interleukin-23 production	IDA IDA: Inferred from direct assay	21145111	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	21350122	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	33723527	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL17RA Protein Structure

SEFIR

0
200
400
600
800
866 a.a.

Protein Preferred Names

Protein Names

interleukin-17 receptor A

IL-17 receptor A

IL17RA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	IL17RA	Q96F46	ns8_sars2	SARS-CoV-2	P0DTC8	Pull Down	33060197
Intra	IL17RA	Q96F46	IL17RE	Homo sapiens	Q8NFR9	Anti Tag CoIP	21993848

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL17RA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70892	IL-17RA Protein, Human (HEK293, His)	Q96F46-1(L33-W320)	≥95%
HY-P71963	IL-17RA Protein, Human (HEK293, hFc)	Q96F46-1(L33-W320)	≥95%
HY-P78147	IL-17RA Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q96F46-1(L33-W320)	≥95%
HY-P78161	IL-17RA Protein, Human (Biotinylated, HEK293, His-Avi)	Q96F46-1(L33-W320)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 51

IMD51	Candf5
Candidiasis, Familial, 5	Candidiasis, Familial, 5, Formerly
Candf5, Formerly	Familial Candidiasis 5
Candidiasis Familial 5 Autosomal Recessive	Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive
Chronic Mucocutaneous Candidiasis 5

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Psoriasis

Folliculitis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Candidiasis

Systemic Candidiasis	Invasive Candidiasis
Disseminated Candidiasis	Systemic Candida Infections
Candidiasis, Invasive

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

Colitis

Cutaneous Candidiasis

Candidiasis, Cutaneous

Hyper Ige Recurrent Infection Syndrome 1

Job Syndrome	Hyper-Ige Recurrent Infection Syndrome 1
Hyperimmunoglobulin E Syndrome	Job'S Syndrome
Recurring Cold Staphylococcal Abscesses	Ige Syndromes
Buckley Syndrome	Hie - [Hyperimmunoglobulin E] Syndrome
Job-Buckley Syndrome	Quie-Hill Syndrome

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Fungal Infectious Disease

Mycoses

Mycosis

Oral Candidiasis

Thrush	Candidiasis Of Mouth
Oral Moniliasis	Thrush, Oral
Candidiasis, Oral	Oral Thrush
Candidiasis	Equine Thrush

Autoimmune Polyendocrine Syndrome

Autoimmune Polyendocrinopathy	Autoimmune Polyglandular Failure
Autoimmune Polyglandular Syndrome	Polyendocrinopathies, Autoimmune
Lloyd'S Syndrome	Aps
Polyendocrinopathies Autoimmune	Polyendocrine Autoimmunity Syndrome
Lloyd Syndrome	Polyglandular Autoimmune Deficiency
Progressive Pluriglandular Insufficiency	Pluriglandular Autoimmune Atrophy
Pluriglandular Autoimmune Syndrome	Thyroid-Adrenocortical Insufficiency Syndrome

Autoimmune Polyendocrine Syndrome Type 1

Whitaker Syndrome	Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy
Autoimmune Polyglandular Syndrome I	Polyglandular Type I Autoimmune Syndrome

Autoimmune Disease Of Skin And Connective Tissue

Vulvovaginal Candidiasis

Candidiasis Of Vulva And Vagina	Candidiasis, Vulvovaginal
Candidal Vulvovaginitis	Candidal: Cervix
Monilial Vulvovaginitis	Candidiasis Vulvovaginal

Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis

Hyper Ige Syndrome

Hyper-Ige Syndrome	Hyper Immunoglobulin E Syndrome
Hies	Hyper-Ige Recurrent Infection Syndrome
Hyperimmunoglobulin E Syndrome	Hyper Ige
Job Syndrome	Hartnup Disease

Ankylosing Spondylitis 1

Ankylosing Spondylitis, Susceptibility To, 1

Spondyloarthropathy

Spondylarthropathies	Spondarthropathy
Spondylarthrosis	Spondyloarthropathy, Susceptibility To
Spondylarthritis

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Meningovascular Neurosyphilis

Psoriasis 11

PSORS11	Psoriasis Susceptibility 11
Psoriasis	Psoriasis Vulgaris
Psoriasis 11, Susceptibility To	Pv

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9924	Ixekizumab	Inhibitor	98.90%	Unkown

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06702	IL17RA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IL17RA	VGNC	VGNC:67763
Canis familiaris	IL17RA	VGNC	VGNC:41946
Macaca mulatta	IL17RA	VGNC	VGNC:73712
Mus musculus	IL17RA	MGD	MGI:107399
Rattus norvegicus	IL17RA	RGD	RGD:1306559
Bos taurus	IL17RA	VGNC	VGNC:30122
Others	IL17RA	NCBI

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