MTCH2 - mitochondrial carrier 2 Gene

Homo sapiens

Also known as MIMP; HSPC032; SLC25A50

Gene ID: 23788 | Gene type: protein coding

About MTCH2

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,604,317-47,642,559 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 216 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 24.0), testis (RPKM 21.8) and 25 other tissues.

Summary

This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]

MTCH2 Products(4)

mRNA	Protein	Name
NM_001317231.2	NP_001304160.1	mitochondrial carrier homolog 2 isoform 1x
NM_001317232.2	NP_001304161.1	mitochondrial carrier homolog 2 isoform 2
NM_001317233.2	NP_001304162.1	mitochondrial carrier homolog 2 isoform 3
NM_014342.4	NP_055157.1	mitochondrial carrier homolog 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables membrane insertase activity	IDA IDA: Inferred from direct assay	36264797	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein insertion into mitochondrial outer membrane	IDA IDA: Inferred from direct assay	36264797	GOA
acts upstream of or within protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	23744079	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	36264797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTCH2 Protein Structure

Mito_carr

0
100
200
303 a.a.

Protein Preferred Names

Protein Names

mitochondrial carrier homolog 2

2310034D24Rik

MTCH2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MTCH2	Q9Y6C9	APOC1	Homo sapiens	P02654	Y2H Prey Pooling	32296183
Intra	MTCH2	Q9Y6C9	APOC1	Homo sapiens	P02654	Y2H Array	32296183
Intra	MTCH2	Q9Y6C9	MP68	Homo sapiens	P56378-2	Y2H Prey Pooling	32296183
Intra	MTCH2	Q9Y6C9	MP68	Homo sapiens	P56378-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Combined Thymoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08755	MTCH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MTCH2	RGD	RGD:1308080
Macaca mulatta	MTCH2	VGNC	VGNC:101364
Bos taurus	MTCH2	VGNC	VGNC:31717
Felis catus	MTCH2	VGNC	VGNC:81978
Mus musculus	MTCH2	MGD	MGI:1929260

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