Enpp7 - ectonucleotide pyrophosphatase/phosphodiesterase 7 Gene

Mus musculus

Also known as Gm254; NPP-7; E-NPP 7; Alk-SMase

Gene ID: 238011 | Gene type: protein coding

About Enpp7

Summary

Enables sphingomyelin phosphodiesterase activity. Involved in several processes, including fatty acid homeostasis; positive regulation of intestinal Cholesterol absorption; and regulation of membrane lipid metabolic process. Predicted to be located in Golgi apparatus and microvillus. Predicted to be integral component of plasma membrane. Orthologous to human ENPP7 (ectonucleotide pyrophosphatase/phosphodiesterase 7). [provided by Alliance of Genome Resources, Apr 2022]

Enpp7 Products(1)

mRNA	Protein	Name
NM_001359574.1	NP_001346503.1	ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables sphingomyelin phosphodiesterase activity	IMP IMP: Inferred from mutant phenotype	21177474	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid homeostasis	IMP IMP: Inferred from mutant phenotype	21177474	MGI
involved in lipid digestion	IMP IMP: Inferred from mutant phenotype	21177474	MGI
involved in positive regulation of ceramide biosynthetic process	IMP IMP: Inferred from mutant phenotype	21177474	MGI
involved in positive regulation of intestinal cholesterol absorption	IMP IMP: Inferred from mutant phenotype	24650549	MGI
involved in positive regulation of sphingomyelin catabolic process	IMP IMP: Inferred from mutant phenotype	21177474	MGI
involved in regulation of intestinal lipid absorption	IMP IMP: Inferred from mutant phenotype	21177474	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ectonucleotide pyrophosphatase/phosphodiesterase family member 7

alkaline sphingomyelin phosphodiesterase

intestinal alkaline sphingomyelinase

Recombinant Enpp7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76902	ENPP-7 Protein, Mouse (HEK293, His)	Q3TIW9 (A22-Q421)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04393	ENPP7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Enpp7	NCBI	NCBI:339221

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