Grem2 - gremlin 2, DAN family BMP antagonist Gene

Mus musculus

Also known as Prdc; Gremlin2

Gene ID: 23893 | Gene type: protein coding

About Grem2

Summary

Enables BMP binding activity; heparin binding activity; and identical protein binding activity. Involved in several processes, including determination of dorsal identity; embryonic body morphogenesis; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including chondrocranium; integument; intestine smooth muscle circular layer; lung; and neural tube. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human GREM2 (gremlin 2, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Apr 2022]

Grem2 Products(1)

mRNA	Protein	Name
NM_011825.1	NP_035955.1	gremlin-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables BMP binding	IMP IMP: Inferred from mutant phenotype	23063586	MGI
enables heparin binding	IDA IDA: Inferred from direct assay	23850456	MGI
enables identical protein binding	IMP IMP: Inferred from mutant phenotype	23063586	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	23850456	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23850456	MGI
involved in determination of dorsal identity	IMP IMP: Inferred from mutant phenotype	23063586	MGI
involved in embryonic body morphogenesis	IMP IMP: Inferred from mutant phenotype	23850456	MGI
involved in negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	23063586	MGI
involved in regulation of cytokine activity	IMP IMP: Inferred from mutant phenotype	23850456	MGI
involved in sequestering of BMP from receptor via BMP binding	IMP IMP: Inferred from mutant phenotype	23063586	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IMP IMP: Inferred from mutant phenotype	23063586	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gremlin-2

Gremlin1	cysteine knot superfamily 1, BMP antagonist 2
gremlin 2 homolog, cysteine knot superfamily	protein related to DAN and cerberus

Recombinant Grem2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79104	PRDC/GREM2 Protein, Mouse	O88273/NP_035955 (R22-Q168)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05785	GREM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grem2	NCBI	NCBI:64388

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