Nr0b2 - nuclear receptor subfamily 0, group B, member 2 Gene

Mus musculus

Also known as SHP; Shp1; SHP-1

Gene ID: 23957 | Gene type: protein coding

About Nr0b2

Summary

This gene encodes a member of the nuclear hormone receptor family of proteins. The encoded Orphan Receptor lacks a DNA binding domain but modulates gene expression by interacting with Other hormone receptors to competitively inhibit binding of coactivators while also acting as a transcriptional corepressor. The encoded receptor may regulate bile acid synthesis and sexual maturation in males. Homozygous knockout mice exhibit accumulation of bile acids, reduced levels of low density lipoprotein Cholesterol (LDL-C), and in male mice, earlier testicular maturation. [provided by RefSeq, Aug 2015]

Nr0b2 Products(1)

mRNA	Protein	Name
NM_011850.3	NP_035980.1	nuclear receptor subfamily 0 group B member 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20375098	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25212631	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	25212631	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear receptor subfamily 0 group B member 2

orphan nuclear receptor SHP

small heterodimer partner

Nr0b2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nr0b2	Q62227	Traf6	Mus musculus	P70196	Confocal	21725320
Intra	Nr0b2	Q62227	Traf6	Mus musculus	P70196	Anti Bait CoIP	21725320
Intra	Nr0b2	Q62227	Rela	Mus musculus	Q04207	Anti Bait CoIP	21725320

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09526	NR0B2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr0b2	NCBI	NCBI:8431

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