AK1 - Ak1 adenylate kinase 1 Gene

Rattus norvegicus

Also known as Ak 1

Gene ID: 24183 | Gene type: protein coding

About AK1

Summary

Enables adenylate kinase activity. Contributes to phosphotransferase activity, phosphate group as acceptor. Involved in several processes, including nervous system development; nucleobase-containing small molecule metabolic process; and positive regulation of neuron maturation. Located in neuron projection; perinuclear region of cytoplasm; and sarcomere. Biomarker of middle cerebral artery infarction; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

AK1 Products(1)

mRNA	Protein	Name
NM_024349.4	NP_077325.2	adenylate kinase isoenzyme 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenylate kinase activity	IDA IDA: Inferred from direct assay	8468325	RGD
contributes to phosphotransferase activity, phosphate group as acceptor	IDA IDA: Inferred from direct assay	19049516	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ADP biosynthetic process	IDA IDA: Inferred from direct assay	19049516	RGD
involved in AMP metabolic process	IDA IDA: Inferred from direct assay	19049516	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	9920788	RGD
involved in inosine biosynthetic process	IDA IDA: Inferred from direct assay	19049516	RGD
involved in muscle organ development	IEP IEP: Inferred from expression pattern	8468325	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	10101232	RGD
involved in olfactory bulb development	IEP IEP: Inferred from expression pattern	9920788	RGD
involved in positive regulation of D-glucose transmembrane transport	IMP IMP: Inferred from mutant phenotype	21059655	RGD
involved in positive regulation of neuron maturation	IEP IEP: Inferred from expression pattern	9920788	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	17002673	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	10383487	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	10383487	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17058275	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	9648858	RGD
located in sarcomere	IDA IDA: Inferred from direct assay	12432079	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adenylate kinase isoenzyme 1

ATP-AMP transphosphorylase 1	ATP:AMP phosphotransferase
adenylate kinase isoenzyme 1-like	adenylate monophosphate kinase
myokinase

Recombinant AK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74427	Adenylate Kinase 1/AK1 Protein, Rat (His)	P39069 (M1-K194)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101465	AK-1	Inhibitor	99.97%	Unkown
HY-RS00505	AK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04242	EIF2AK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	AK1	NCBI	NCBI:203
Macaca fascicularis	AK1	NCBI	NCBI:101867187
Mus musculus	AK1	NCBI	NCBI:11636

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