2. Gene
  3. Vtcn1 - V-set domain containing T cell activation inhibitor 1 Gene

Vtcn1 - V-set domain containing T cell activation inhibitor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as B7x; B7h4; B7s1

Gene ID: 242122 | Gene type: protein coding

About Vtcn1

Summary

Enables signaling receptor binding activity. Acts upstream of or within positive regulation of interleukin-2 production; regulation of T cell activation; and response to protozoan. Located in external side of plasma membrane. Is expressed in hemolymphoid system gland; lung; male reproductive gland or organ; and pancreas. Orthologous to human VTCN1 (V-set domain containing T cell activation inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

Vtcn1 Products(3)

mRNA Protein Name
NM_001409755.1 NP_001396684.1 V-set domain containing T-cell activation inhibitor 1 isoform 2
NM_001409758.1 NP_001396687.1 V-set domain containing T-cell activation inhibitor 1 isoform 2
NM_178594.4 NP_848709.2 V-set domain containing T-cell activation inhibitor 1 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables signaling receptor binding IDA
IDA: Inferred from direct assay
16751379 MGI
enables signaling receptor binding IGI
IGI: Inferred from genetic interaction
15585831 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within interleukin-4 production IMP
IMP: Inferred from mutant phenotype
16914726 MGI
acts upstream of or within negative regulation of T cell activation IDA
IDA: Inferred from direct assay
15585831 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
16751379 MGI
acts upstream of or within positive regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
16751379 MGI
acts upstream of or within response to protozoan IMP
IMP: Inferred from mutant phenotype
16914726 MGI
acts upstream of or within type II interferon production IMP
IMP: Inferred from mutant phenotype
16914726 MGI
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17051145 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

V-set domain containing T-cell activation inhibitor 1

B7 homolog 4

immune costimulatory protein B7-H4

t cell costimulatory molecule B7x

Recombinant Vtcn1 Proteins

Cat. No. Product Name Accession Purity
HY-P7641 B7-H4 Protein, Mouse (HEK293, Fc) Q7TSP5/AAH32925.1 (F29-P258) ≥95%
HY-P74393 B7-H4 Protein, Mouse (sf9, His) Q7TSP5 (F29-S256) ≥95%
HY-P74394 B7-H4 Protein, Mouse (HEK293, His) Q7TSP5 (F29-S256) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15721 VTCN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990059 Puxitatug 99.00% Unkown
HY-P990918 Emiltatug / Unkown
HY-P990953 Zubotamig Inhibitor / Unkown
HY-P990996 Felmetatug / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vtcn1 NCBI NCBI:79679
Rattus norvegicus Vtcn1 NCBI NCBI:295322