VTCN1 - V-set domain containing T cell activation inhibitor 1 Gene

Homo sapiens

Also known as B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291

Gene ID: 79679 | Gene type: protein coding

About VTCN1

Cytogenetic location: 1p13.1-p12 Genomic coordinates (GRCh38): 1:117,143,587-117,210,927 (from NCBI)

This gene has 6 transcripts (splice variants), 182 orthologues and 15 paralogues. Biased expression in kidney (RPKM 5.0), pancreas (RPKM 2.8) and 9 other tissues.

Summary

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

VTCN1 Products(3)

mRNA	Protein	Name
NM_001253849.2	NP_001240778.1	V-set domain-containing T-cell activation inhibitor 1 isoform 2
NM_001253850.2	NP_001240779.1	V-set domain-containing T-cell activation inhibitor 1 isoform 3
NM_024626.4	NP_078902.2	V-set domain-containing T-cell activation inhibitor 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	16606666	GOA
involved in negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	16606666	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15878339	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	16606666	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VTCN1 Protein Structure

V-set

Ig_3

0
100
200
282 a.a.

Protein Preferred Names

Protein Names

V-set domain-containing T-cell activation inhibitor 1

B7 family member, H4

VTCN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VTCN1	Q7Z7D3	NCALD	Homo sapiens	P61601	Anti Tag CoIP	33961781
Intra	VTCN1	Q7Z7D3	NCALD	Homo sapiens	P61601	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VTCN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7640	B7-H4 Protein, Human (HEK293, Fc)	Q7Z7D3-1 (F29-A258)	≥95%
HY-P72341	B7-H4 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q7Z7D3-1 (F29-A258)	≥95%
HY-P74395	B7-H4 Protein, Human (HEK293, His)	Q7Z7D3-1 (F29-A258)	≥95%
HY-P77541	B7-H4 Protein, Human (Biotinylated, HEK293, His)	Q7Z7D3-1 (F29-A258)	≥95%
HY-P78073	B7-H4 Protein, Human (Biotinylated, HEK293, His-Avi)	Q7Z7D3-1 (F29-A258)	≥95%
HY-P78390	B7-H4 Protein, Human (HEK293, His-Avi)	Q7Z7D3-1 (F29-A258)	≥95%

Related Diseases

Diseases

Alias

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15721	VTCN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VTCN1	VGNC	VGNC:36848
Macaca mulatta	VTCN1	VGNC	VGNC:79749
Mus musculus	VTCN1	MGD	MGI:3039619
Rattus norvegicus	VTCN1	RGD	RGD:1311204
Canis familiaris	VTCN1	VGNC	VGNC:48315
Felis catus	VTCN1	VGNC	VGNC:66988
Others	VTCN1	NCBI

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