Gdf6 - growth differentiation factor 6 Gene

Mus musculus

Also known as BMP13; GDF16; BMP-13

Gene ID: 242316 | Gene type: protein coding

About Gdf6

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mice lacking a functional copy of this gene exhibit joint and skeletal defects. [provided by RefSeq, Sep 2016]

Gdf6 Products(1)

mRNA	Protein	Name
NM_013526.1	NP_038554.1	growth/differentiation factor 6 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16049014	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	16049014	MGI
acts upstream of or within BMP signaling pathway	IGI IGI: Inferred from genetic interaction	16049014	MGI
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	26774823	MGI
acts upstream of or within positive effect cell migration involved in metanephros development	IMP IMP: Inferred from mutant phenotype	32737436	MGI
acts upstream of or within positive effect epithelial cell migration	IMP IMP: Inferred from mutant phenotype	32737436	MGI
involved in fat cell differentiation	IMP IMP: Inferred from mutant phenotype	26774823	MGI
involved in metanephros development	IMP IMP: Inferred from mutant phenotype	32737436	MGI
involved in positive regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	26774823	MGI
acts upstream of or within positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	9786991	MGI
involved in positive regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	26774823	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

growth/differentiation factor 6

GDF-6	bone morphogenetic protein 13
growth/differentiation factor 16

Recombinant Gdf6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79333	BMP-13/GDF-6 Protein, Mouse	P43028 (T335-R454)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05356	GDF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gdf6	NCBI	NCBI:392255

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