Il1b - interleukin 1 beta Gene

Rattus norvegicus

Also known as IL-1F2

Gene ID: 24494 | Gene type: protein coding

About Il1b

Primary_assembly 3: 116,577,010-116,583,415 reverse strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 233 orthologues, 6 paralogues and is associated with 280 phenotypes. Biased expression in Spleen (RPKM 194.1), Lung (RPKM 63.3) and 6 other tissues.

Summary

Enables cytokine activity. Involved in several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and regulation of neurogenesis. Located in extracellular space. Used to study several diseases, including artery disease (multiple); brain disease (multiple); glomerulonephritis (multiple); interstitial lung disease (multiple); and kidney failure (multiple). Biomarker of several diseases, including artery disease (multiple); auditory system disease (multiple); brain disease (multiple); kidney failure (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); eye disease (multiple); gastrointestinal system Cancer (multiple); and lung disease (multiple). Orthologous to human IL1B (interleukin 1 beta). [provided by Alliance of Genome Resources, Apr 2022]

Il1b Products(1)

mRNA	Protein	Name
NM_031512.2	NP_113700.2	interleukin-1 beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	22279542	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to antibiotic	IEP IEP: Inferred from expression pattern	23200736	RGD
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	23086551	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	23053967	RGD
involved in cellular response to lipid	IEP IEP: Inferred from expression pattern	22964727	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	23200736	RGD
involved in chronic inflammatory response to antigenic stimulus	IEP IEP: Inferred from expression pattern	15050649	RGD
involved in fever generation	IEP IEP: Inferred from expression pattern	16455768	RGD
involved in learning or memory	IEP IEP: Inferred from expression pattern	17650650	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	15050649	RGD
involved in negative regulation of branching morphogenesis of a nerve	IDA IDA: Inferred from direct assay	22270046	RGD
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	23168994	RGD
involved in negative regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	12667655	RGD
involved in negative regulation of neural precursor cell proliferation	IDA IDA: Inferred from direct assay	22270046	RGD
involved in negative regulation of neurogenesis	IDA IDA: Inferred from direct assay	22270046	RGD
involved in negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	22270046	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23219998	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	15671867	RGD
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	15671867	RGD
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	12667655	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	22270046	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16038625	RGD
involved in positive regulation of astrocyte differentiation	IDA IDA: Inferred from direct assay	22270046	RGD
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15671867	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	12213318	RGD
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	22279542	RGD
involved in positive regulation of glial cell differentiation	IDA IDA: Inferred from direct assay	23168994	RGD
involved in positive regulation of immature T cell proliferation in thymus	IDA IDA: Inferred from direct assay	8590311	RGD
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	15671867	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	23262920	RGD
involved in positive regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	1519663	RGD
involved in positive regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	15671867	RGD
involved in positive regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	12629164	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19717791	RGD
involved in regulation of neurogenesis	IGI IGI: Inferred from genetic interaction	20018408	RGD
involved in response to L-ascorbic acid	IEP IEP: Inferred from expression pattern	18983910	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	21898269	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	17678971	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	23206318	RGD
involved in response to gamma radiation	IEP IEP: Inferred from expression pattern	16524844	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	17621647	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	19342292	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	25641164	RGD
involved in response to isolation stress	IEP IEP: Inferred from expression pattern	33411841	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17201737	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	17437639	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17071120	RGD
involved in response to ozone	IEP IEP: Inferred from expression pattern	17901407	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	22956308	RGD
involved in response to stilbenoid	IEP IEP: Inferred from expression pattern	23211629	RGD
involved in response to vitamin D	IEP IEP: Inferred from expression pattern	17621647	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17071120	RGD
involved in social behavior	IMP IMP: Inferred from mutant phenotype	9831177	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	17201737	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il1b Protein Structure

IL1_propep

IL1

0
100
200
268 a.a.

Protein Preferred Names

Protein Names

interleukin-1 beta

IL-1 beta

Recombinant Il1b Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7097	IL-1 beta Protein, Rat	Q63264 (V117-S268)	≥95%
HY-P7097A	IL-1 beta Protein, Rat (His)	Q5BKB0 (V117-S268)	≥95%
HY-P73900	IL-1 beta Protein, Rat (268a.a, His)	Q63264 (M1-S268)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1137	10Panx	Inhibitor	99.40%	Unkown
HY-141852	STAMBP-IN-1	Inhibitor	98.37%	Unkown
HY-P1117	MMK1		99.22%	Unkown
HY-147105	LRH-1 modulator-1	Agonist	98.04%	Unkown
HY-147105A	(+)-LRH-1 modulator-1		99.38%	Unkown
HY-111662	Fc 11a-2	Inhibitor	/	Unkown
HY-162168	Anti-inflammatory agent 71	Inhibitor	/	Unkown
HY-P1117A	MMK1 TFA		/	Unkown
HY-RS06716	IL1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06717	Il1b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06718	Il1b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99139	Anti-Mouse IL-1b Antibody (B122)	Inhibitor	95.00%	Unkown
HY-P990563	CDP-484		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il1b	NCBI	NCBI:3553
Canis familiaris	Il1b	NCBI	NCBI:403974
Felis catus	Il1b	NCBI	NCBI:768274
Macaca fascicularis	Il1b	NCBI	NCBI:102119749
Mus musculus	Il1b	NCBI	NCBI:16176
Susscrofa domestica	Il1b	NCBI
Leporidae	Il1b	NCBI
Macaca mulatta	Il1b	NCBI	NCBI:704701

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