ATP6V0D2 - ATPase H+ transporting V0 subunit d2 Gene

Homo sapiens

Also known as VMA6; ATP6D2

Gene ID: 245972 | Gene type: protein coding

About ATP6V0D2

Cytogenetic location: 8q21.3 Genomic coordinates (GRCh38): 8:86,098,910-86,154,225 (from NCBI)

This gene has 3 transcripts (splice variants), 173 orthologues and 1 paralogue. Biased expression in kidney (RPKM 22.7) and colon (RPKM 1.1).

Summary

Predicted to enable proton transmembrane transporter activity. Predicted to be involved in vacuolar acidification and vacuolar transport. Located in apical plasma membrane. Part of vacuolar proton-transporting V-type ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]

ATP6V0D2 Products(1)

mRNA	Protein	Name
NM_152565.1	NP_689778.1	V-type proton ATPase subunit d 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18752060	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15800125	GOA
located in membrane	IDA IDA: Inferred from direct assay	18752060	GOA
part of vacuolar proton-transporting V-type ATPase complex	IDA IDA: Inferred from direct assay	18752060	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP6V0D2 Protein Structure

vATP-synt_AC39

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

V-type proton ATPase subunit d 2

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2

ATP6V0D2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ATP6V0D2	Q8N8Y2	CENPP	Homo sapiens	Q6IPU0	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	CENPP	Homo sapiens	Q6IPU0	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	RIBC1	Homo sapiens	Q8N443	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	RIBC1	Homo sapiens	Q8N443	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	PHF12	Homo sapiens	Q96QT6-2	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	PHF12	Homo sapiens	Q96QT6-2	Validated Y2H	32296183
Intra	ATP6V0D2	Q8N8Y2	PHF12	Homo sapiens	Q96QT6-2	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	SEPTIN2	Homo sapiens	Q15019-3	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	SEPTIN2	Homo sapiens	Q15019-3	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	POMC	Homo sapiens	P01189	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	POMC	Homo sapiens	P01189	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	NICN1	Homo sapiens	Q9BSH3	Validated Y2H	32296183
Intra	ATP6V0D2	Q8N8Y2	NICN1	Homo sapiens	Q9BSH3	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	NICN1	Homo sapiens	Q9BSH3	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	ZNF474	Homo sapiens	Q6S9Z5	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	ZNF474	Homo sapiens	Q6S9Z5	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32296183
Intra	ATP6V0D2	Q8N8Y2	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	ATP6V0D2	Q8N8Y2	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	CRX	Homo sapiens	O43186	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183
Intra	ATP6V0D2	Q8N8Y2	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	ATP6V0D2	Q8N8Y2	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Distal Renal Tubular Acidosis

Classic Rta	Familial Distal Primary Acidosis
Renal Tubular Acidosis Type 1	Drta
Renal Tubular Acidosis, Distal

Osteopetrosis, Autosomal Recessive 3

Osteopetrosis With Renal Tubular Acidosis	Marble Brain Disease
OPTB3	Guibaud-Vainsel Syndrome
Carbonic Anhydrase Ii Deficiency	Osteopetrosis, Autosomal Recessive 3, With Renal Tubular Acidosis
Autosomal Recessive Osteopetrosis 3	Carbonic Anhydrase 2 Deficiency
Autosomal Recessive Osteopetrosis 3 With Renal Tubular Acidosis	Osteopetrosis Autosomal Recessive 3
Autosomal Recessive Osteopetrosis Type 3	Guibaud Vainsel Syndrome
Mixed Rta	Mixed Renal Tubular Acidosis
Renal Tubular Acidosis Type 3	Carbonic Anhydrase Ii Deficiency Syndrome
Carbonic Anhydrase Ii Variant	Osteopetrosis, Autosomal Recessive, Type 3
Carbonic Anhydrase 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01222	ATP6V0D2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATP6V0D2	VGNC	VGNC:99682
Canis familiaris	ATP6V0D2	VGNC	VGNC:38274
Bos taurus	ATP6V0D2	VGNC	VGNC:26313
Rattus norvegicus	ATP6V0D2	RGD	RGD:1306900
Mus musculus	ATP6V0D2	MGD	MGI:1924415
Macaca mulatta	ATP6V0D2	VGNC	VGNC:70093

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