Pdgfb - platelet derived growth factor subunit B Gene

Rattus norvegicus

Also known as SIS; c-sis

Gene ID: 24628 | Gene type: protein coding

About Pdgfb

Summary

Enables signaling receptor binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of cell migration; and response to peptide hormone. Located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Used to study asthma; brain infarction; glomerulonephritis; and visual epilepsy. Biomarker of cholestasis; hypertension (multiple); liver cirrhosis; oligohydramnios; and ureteral obstruction. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue Cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Apr 2022]

Pdgfb Products(2)

mRNA	Protein	Name
NM_031524.1	NP_113712.1	platelet-derived growth factor subunit B precursor
NM_031524.1	NP_113712.1	platelet-derived growth factor subunit B precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables signaling receptor binding	IMP IMP: Inferred from mutant phenotype	16014047	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	10506481	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	7653578	RGD
involved in cellular response to mycophenolic acid	IDA IDA: Inferred from direct assay	18723570	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	11870082	RGD
involved in myoblast proliferation	IEP IEP: Inferred from expression pattern	2425941	RGD
involved in platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17449016	RGD
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	12084843	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18723570	RGD
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	19460854	RGD
involved in positive regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	15358192	RGD
involved in positive regulation of hepatic stellate cell activation	IMP IMP: Inferred from mutant phenotype	15358192	RGD
involved in positive regulation of hepatic stellate cell proliferation	IMP IMP: Inferred from mutant phenotype	15358192	RGD
involved in positive regulation of metanephric mesenchymal cell migration	IDA IDA: Inferred from direct assay	19460854	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	17449016	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17449016	RGD
involved in regulation of cell population proliferation	IEP IEP: Inferred from expression pattern	7758166	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	7922556	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	14724432	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	14724432	RGD
involved in response to human chorionic gonadotropin	IEP IEP: Inferred from expression pattern	17108335	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	8447423	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	12606528	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16156274	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16156274	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	10550325	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	10550325	RGD
located in dendrite	IDA IDA: Inferred from direct assay	14980813	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	9072322	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	7922556	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

platelet-derived growth factor subunit B

PDGF subunit B	PDGF-2
Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)	pdgf protein
platelet derived growth factor, B polypeptide	platelet derived growth factor-bb
platelet-derived growth factor B chain	p

Recombinant Pdgfb Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7278	PDGF-BB Protein, Rat	Q05028 (S74-T182)	≥95%
HY-P7278A	PDGF-BB Protein, Rat (His)	Q05028 (S74-T182)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160047	AX102 sodium		/	Unkown
HY-160048	PEG40K unconjugated/naked AX102 sodium		/	Unkown
HY-RS10251	PDGFB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdgfb	NCBI	NCBI:5155
Canis familiaris	Pdgfb	NCBI	NCBI:442986
Macaca fascicularis	Pdgfb	NCBI	NCBI:102125183
Mus musculus	Pdgfb	NCBI	NCBI:18591
Macaca mulatta	Pdgfb	NCBI	NCBI:703173

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